Relationship between serum osteoprotegerin and vascular calcifications in hemodialysis patients
Background: Uremia is a vasculopathic process, and both cardiac calcification and vascular calcification seen from the early stages of chronic kidney disease. Osteoprotegerin could play a crucial role in atherosclerotic plaque formation, maturation and calcification. The goal of this study was to de...
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doaj-ddceca6f4143435cba1ea3fe2e7f758d2020-11-25T01:21:51ZengSpringerOpenThe Egyptian Heart Journal1110-26082017-06-0169214915510.1016/j.ehj.2017.02.004Relationship between serum osteoprotegerin and vascular calcifications in hemodialysis patientsTarek Z. El Baz0Osama A. Khamis1Amal El-Shehaby2Hussein Chahine3Ahmad Alaa Al-Din Ahmed4Mostafa A. Alsawasany5Internal Medicine, Faculty of Medicine, AL-Azhar University, Cairo, EgyptInternal Medicine, Faculty of Medicine, AL-Azhar University, Cairo, EgyptDepartment of Medical Biochemistry, Faculty of Medicine, Cairo University, Cairo, EgyptInternal Medicine, Faculty of Medicine, AL-Azhar University, Cairo, EgyptInternal Medicine, Faculty of Medicine, AL-Azhar University, Cairo, EgyptDepartment Cardiology, Faculties of Medicine, Al-Azhar University, Cairo, EgyptBackground: Uremia is a vasculopathic process, and both cardiac calcification and vascular calcification seen from the early stages of chronic kidney disease. Osteoprotegerin could play a crucial role in atherosclerotic plaque formation, maturation and calcification. The goal of this study was to determine the relationship of serum osteoprotegerin with vascular calcification in patients with end stage kidney disease who were maintained on regular hemodialysis. Methods: Sixty clinically stable chronic renal failure patients undergoing regular hemodialysis were enrolled in this cross sectional study. Thirty patients (mean age 56.7 ± 10.5 years) with abdominal aortic calcification were selected by basal abdominal X-ray who underwent multi-slice computerized tomography scan to measure coronary artery calcification score; and thirty patients (mean age 56.5 ± 8.4 years) without abdominal aortic calcification. All patients were evaluated by serum calcium, phosphorus, albumin, lipid profile, intact parathyroid hormone (iPTH), serum creatinine, serum urea, serum uric acid, serum C-reactive protein, and hemoglobin. Serum osteoprotegerin samples were collected before dialysis and estimated by the ELISA kit. Results: Serum osteoprotegerin level was significantly higher in patients with vascular calcification than in those without calcifications. Serum osteoprotegerin correlated positively with serum phosphorus, calcium phosphorus product, alkaline phosphatase, iPTH, C-reactive protein, serum uric acid, low-density lipoprotein (LDL) and left ventricular mass index (LVMI) (p < 0.005), and negatively with hemoglobin, ejection fraction (p < 0.005) and HDL (p < 0.05). Conclusions: These findings suggest that osteoprotegerin may be involved in the development of vascular calcification in hemodialysis patients.http://www.sciencedirect.com/science/article/pii/S111026081630093XVascular calcificationOsteoprotegerinHemodialysis patients |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tarek Z. El Baz Osama A. Khamis Amal El-Shehaby Hussein Chahine Ahmad Alaa Al-Din Ahmed Mostafa A. Alsawasany |
spellingShingle |
Tarek Z. El Baz Osama A. Khamis Amal El-Shehaby Hussein Chahine Ahmad Alaa Al-Din Ahmed Mostafa A. Alsawasany Relationship between serum osteoprotegerin and vascular calcifications in hemodialysis patients The Egyptian Heart Journal Vascular calcification Osteoprotegerin Hemodialysis patients |
author_facet |
Tarek Z. El Baz Osama A. Khamis Amal El-Shehaby Hussein Chahine Ahmad Alaa Al-Din Ahmed Mostafa A. Alsawasany |
author_sort |
Tarek Z. El Baz |
title |
Relationship between serum osteoprotegerin and vascular calcifications in hemodialysis patients |
title_short |
Relationship between serum osteoprotegerin and vascular calcifications in hemodialysis patients |
title_full |
Relationship between serum osteoprotegerin and vascular calcifications in hemodialysis patients |
title_fullStr |
Relationship between serum osteoprotegerin and vascular calcifications in hemodialysis patients |
title_full_unstemmed |
Relationship between serum osteoprotegerin and vascular calcifications in hemodialysis patients |
title_sort |
relationship between serum osteoprotegerin and vascular calcifications in hemodialysis patients |
publisher |
SpringerOpen |
series |
The Egyptian Heart Journal |
issn |
1110-2608 |
publishDate |
2017-06-01 |
description |
Background: Uremia is a vasculopathic process, and both cardiac calcification and vascular calcification seen from the early stages of chronic kidney disease. Osteoprotegerin could play a crucial role in atherosclerotic plaque formation, maturation and calcification. The goal of this study was to determine the relationship of serum osteoprotegerin with vascular calcification in patients with end stage kidney disease who were maintained on regular hemodialysis.
Methods: Sixty clinically stable chronic renal failure patients undergoing regular hemodialysis were enrolled in this cross sectional study. Thirty patients (mean age 56.7 ± 10.5 years) with abdominal aortic calcification were selected by basal abdominal X-ray who underwent multi-slice computerized tomography scan to measure coronary artery calcification score; and thirty patients (mean age 56.5 ± 8.4 years) without abdominal aortic calcification. All patients were evaluated by serum calcium, phosphorus, albumin, lipid profile, intact parathyroid hormone (iPTH), serum creatinine, serum urea, serum uric acid, serum C-reactive protein, and hemoglobin. Serum osteoprotegerin samples were collected before dialysis and estimated by the ELISA kit.
Results: Serum osteoprotegerin level was significantly higher in patients with vascular calcification than in those without calcifications. Serum osteoprotegerin correlated positively with serum phosphorus, calcium phosphorus product, alkaline phosphatase, iPTH, C-reactive protein, serum uric acid, low-density lipoprotein (LDL) and left ventricular mass index (LVMI) (p < 0.005), and negatively with hemoglobin, ejection fraction (p < 0.005) and HDL (p < 0.05).
Conclusions: These findings suggest that osteoprotegerin may be involved in the development of vascular calcification in hemodialysis patients. |
topic |
Vascular calcification Osteoprotegerin Hemodialysis patients |
url |
http://www.sciencedirect.com/science/article/pii/S111026081630093X |
work_keys_str_mv |
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