Novel Applications of Metabolomics in Personalized Medicine: A Mini-Review
Interindividual variability in drug responses and disease susceptibility is common in the clinic. Currently, personalized medicine is highly valued, the idea being to prescribe the right medicine to the right patient. Metabolomics has been increasingly applied in evaluating the therapeutic outcomes...
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doaj-ddd05e664fa44dd5b92a80b8fe00bebc2020-11-25T00:38:15ZengMDPI AGMolecules1420-30492017-07-01227117310.3390/molecules22071173molecules22071173Novel Applications of Metabolomics in Personalized Medicine: A Mini-ReviewBingbing Li0Xuyun He1Wei Jia2Houkai Li3Center for Traditional Chinese Medicine and Systems Biology, Institute for Interdisciplinary Medicine Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaCenter for Traditional Chinese Medicine and Systems Biology, Institute for Interdisciplinary Medicine Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaCancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USACenter for Traditional Chinese Medicine and Systems Biology, Institute for Interdisciplinary Medicine Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaInterindividual variability in drug responses and disease susceptibility is common in the clinic. Currently, personalized medicine is highly valued, the idea being to prescribe the right medicine to the right patient. Metabolomics has been increasingly applied in evaluating the therapeutic outcomes of clinical drugs by correlating the baseline metabolic profiles of patients with their responses, i.e., pharmacometabonomics, as well as prediction of disease susceptibility among population in advance, i.e., patient stratification. The accelerated advance in metabolomics technology pinpoints the huge potential of its application in personalized medicine. In current review, we discussed the novel applications of metabolomics with typical examples in evaluating drug therapy and patient stratification, and underlined the potential of metabolomics in personalized medicine in the future.https://www.mdpi.com/1420-3049/22/7/1173metabolomicspersonalized medicineinterindividual variabilitypharmaco-metabonomicspatient stratification |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bingbing Li Xuyun He Wei Jia Houkai Li |
spellingShingle |
Bingbing Li Xuyun He Wei Jia Houkai Li Novel Applications of Metabolomics in Personalized Medicine: A Mini-Review Molecules metabolomics personalized medicine interindividual variability pharmaco-metabonomics patient stratification |
author_facet |
Bingbing Li Xuyun He Wei Jia Houkai Li |
author_sort |
Bingbing Li |
title |
Novel Applications of Metabolomics in Personalized Medicine: A Mini-Review |
title_short |
Novel Applications of Metabolomics in Personalized Medicine: A Mini-Review |
title_full |
Novel Applications of Metabolomics in Personalized Medicine: A Mini-Review |
title_fullStr |
Novel Applications of Metabolomics in Personalized Medicine: A Mini-Review |
title_full_unstemmed |
Novel Applications of Metabolomics in Personalized Medicine: A Mini-Review |
title_sort |
novel applications of metabolomics in personalized medicine: a mini-review |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2017-07-01 |
description |
Interindividual variability in drug responses and disease susceptibility is common in the clinic. Currently, personalized medicine is highly valued, the idea being to prescribe the right medicine to the right patient. Metabolomics has been increasingly applied in evaluating the therapeutic outcomes of clinical drugs by correlating the baseline metabolic profiles of patients with their responses, i.e., pharmacometabonomics, as well as prediction of disease susceptibility among population in advance, i.e., patient stratification. The accelerated advance in metabolomics technology pinpoints the huge potential of its application in personalized medicine. In current review, we discussed the novel applications of metabolomics with typical examples in evaluating drug therapy and patient stratification, and underlined the potential of metabolomics in personalized medicine in the future. |
topic |
metabolomics personalized medicine interindividual variability pharmaco-metabonomics patient stratification |
url |
https://www.mdpi.com/1420-3049/22/7/1173 |
work_keys_str_mv |
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1725298128198828032 |