Periodic fasting alters neuronal excitability in rat neocortical and hippocampal tissues
Dietary restriction has been shown to be associated with marked changes in brain function. Periodic fasting was suggested to be beneficial in reducing both the incidence and severity of some neurological disorders. The aim of this investigation was to study the effect of periodic fasting on the neur...
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doaj-ddd0e310ee7540a18b8b6a98fd03fe072021-03-20T04:58:10ZengElsevierNeurobiology of Disease1095-953X2009-11-01362384392Periodic fasting alters neuronal excitability in rat neocortical and hippocampal tissuesMaryam Khaleghi Ghadiri0Yasemin Tutam1Hansdetlef Wassmann2Erwin-Josef Speckmann3Ali Gorji4Klinik und Poliklinik für Neurochirurgie, Universitätsklinikum Münster, Münster, GermanyInstitut für Physiologie I, Westfälische Wilhelms-Universität Münster, Robert-Koch-Strasse 27a, D-48149 Münster, GermanyKlinik und Poliklinik für Neurochirurgie, Universitätsklinikum Münster, Münster, GermanyInstitut für Physiologie I, Westfälische Wilhelms-Universität Münster, Robert-Koch-Strasse 27a, D-48149 Münster, GermanyInstitut für Physiologie I, Westfälische Wilhelms-Universität Münster, Robert-Koch-Strasse 27a, D-48149 Münster, Germany; Corresponding author. Fax: +49 251 8355551.Dietary restriction has been shown to be associated with marked changes in brain function. Periodic fasting was suggested to be beneficial in reducing both the incidence and severity of some neurological disorders. The aim of this investigation was to study the effect of periodic fasting on the neuronal network excitability in the neocortex and hippocampus and its possible influence on the brain under pathological conditions. Direct current (DC) recordings in the somatosensory neocortex of fasting rats (15 h water and food deprivation per day) during drinking revealed a negative potential shift. Using voltage sensitive dye imaging and tetanus-induced long-term potentiation (LTP) in ex vivo/in vitro experiments, neuronal network activities as well as synaptic efficacy were investigated in rat neocortical and hippocampal slices after 4 weeks of periodic fasting. Stimulus-induced patterns of bioelectric activity showed enhanced neuronal network excitability in the neocortex and decreased bioelectric activity in the hippocampus. LTP was significantly increased in neocortical slices and inhibited in hippocampal tissues. Both hippocampal and neocortical tissues exhibited a higher tolerance to hypoxic stress but not to 0-Mg2+-eliciting epileptiform field potentials. Neocortical slices also exhibited a higher threshold for the initiation of spreading depression. These experiments indicate that repetitive DC potential shifts occurring in fasting rats change the pattern of bioelectrical activities in cortical and subcortical regions. Through these alterations, the neocortex and hippocampus may become tuned for the efficient regulation of consummatory behaviour.http://www.sciencedirect.com/science/article/pii/S0969996109002228Diet therapyHeadacheStrokeAlzheimerParkinsonCortical excitation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maryam Khaleghi Ghadiri Yasemin Tutam Hansdetlef Wassmann Erwin-Josef Speckmann Ali Gorji |
spellingShingle |
Maryam Khaleghi Ghadiri Yasemin Tutam Hansdetlef Wassmann Erwin-Josef Speckmann Ali Gorji Periodic fasting alters neuronal excitability in rat neocortical and hippocampal tissues Neurobiology of Disease Diet therapy Headache Stroke Alzheimer Parkinson Cortical excitation |
author_facet |
Maryam Khaleghi Ghadiri Yasemin Tutam Hansdetlef Wassmann Erwin-Josef Speckmann Ali Gorji |
author_sort |
Maryam Khaleghi Ghadiri |
title |
Periodic fasting alters neuronal excitability in rat neocortical and hippocampal tissues |
title_short |
Periodic fasting alters neuronal excitability in rat neocortical and hippocampal tissues |
title_full |
Periodic fasting alters neuronal excitability in rat neocortical and hippocampal tissues |
title_fullStr |
Periodic fasting alters neuronal excitability in rat neocortical and hippocampal tissues |
title_full_unstemmed |
Periodic fasting alters neuronal excitability in rat neocortical and hippocampal tissues |
title_sort |
periodic fasting alters neuronal excitability in rat neocortical and hippocampal tissues |
publisher |
Elsevier |
series |
Neurobiology of Disease |
issn |
1095-953X |
publishDate |
2009-11-01 |
description |
Dietary restriction has been shown to be associated with marked changes in brain function. Periodic fasting was suggested to be beneficial in reducing both the incidence and severity of some neurological disorders. The aim of this investigation was to study the effect of periodic fasting on the neuronal network excitability in the neocortex and hippocampus and its possible influence on the brain under pathological conditions. Direct current (DC) recordings in the somatosensory neocortex of fasting rats (15 h water and food deprivation per day) during drinking revealed a negative potential shift. Using voltage sensitive dye imaging and tetanus-induced long-term potentiation (LTP) in ex vivo/in vitro experiments, neuronal network activities as well as synaptic efficacy were investigated in rat neocortical and hippocampal slices after 4 weeks of periodic fasting. Stimulus-induced patterns of bioelectric activity showed enhanced neuronal network excitability in the neocortex and decreased bioelectric activity in the hippocampus. LTP was significantly increased in neocortical slices and inhibited in hippocampal tissues. Both hippocampal and neocortical tissues exhibited a higher tolerance to hypoxic stress but not to 0-Mg2+-eliciting epileptiform field potentials. Neocortical slices also exhibited a higher threshold for the initiation of spreading depression. These experiments indicate that repetitive DC potential shifts occurring in fasting rats change the pattern of bioelectrical activities in cortical and subcortical regions. Through these alterations, the neocortex and hippocampus may become tuned for the efficient regulation of consummatory behaviour. |
topic |
Diet therapy Headache Stroke Alzheimer Parkinson Cortical excitation |
url |
http://www.sciencedirect.com/science/article/pii/S0969996109002228 |
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