Cohort Profile: ZOE 2.0—A Community-Based Genetic Epidemiologic Study of Early Childhood Oral Health
Early childhood caries (ECC) is an aggressive form of dental caries occurring in the first five years of life. Despite its prevalence and consequences, little progress has been made in its prevention and even less is known about individuals’ susceptibility or genomic risk factors. The genome-wide as...
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MDPI AG
2020-11-01
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Series: | International Journal of Environmental Research and Public Health |
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Online Access: | https://www.mdpi.com/1660-4601/17/21/8056 |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kimon Divaris Gary D. Slade Andrea G. Ferreira Zandona John S. Preisser Jeannie Ginnis Miguel A. Simancas-Pallares Cary S. Agler Poojan Shrestha Deepti S. Karhade Apoena de Aguiar Ribeiro Hunyong Cho Yu Gu Beau D. Meyer Ashwini R. Joshi M. Andrea Azcarate-Peril Patricia V. Basta Di Wu Kari E. North |
spellingShingle |
Kimon Divaris Gary D. Slade Andrea G. Ferreira Zandona John S. Preisser Jeannie Ginnis Miguel A. Simancas-Pallares Cary S. Agler Poojan Shrestha Deepti S. Karhade Apoena de Aguiar Ribeiro Hunyong Cho Yu Gu Beau D. Meyer Ashwini R. Joshi M. Andrea Azcarate-Peril Patricia V. Basta Di Wu Kari E. North Cohort Profile: ZOE 2.0—A Community-Based Genetic Epidemiologic Study of Early Childhood Oral Health International Journal of Environmental Research and Public Health children early childhood caries community-based studies oral health genomics |
author_facet |
Kimon Divaris Gary D. Slade Andrea G. Ferreira Zandona John S. Preisser Jeannie Ginnis Miguel A. Simancas-Pallares Cary S. Agler Poojan Shrestha Deepti S. Karhade Apoena de Aguiar Ribeiro Hunyong Cho Yu Gu Beau D. Meyer Ashwini R. Joshi M. Andrea Azcarate-Peril Patricia V. Basta Di Wu Kari E. North |
author_sort |
Kimon Divaris |
title |
Cohort Profile: ZOE 2.0—A Community-Based Genetic Epidemiologic Study of Early Childhood Oral Health |
title_short |
Cohort Profile: ZOE 2.0—A Community-Based Genetic Epidemiologic Study of Early Childhood Oral Health |
title_full |
Cohort Profile: ZOE 2.0—A Community-Based Genetic Epidemiologic Study of Early Childhood Oral Health |
title_fullStr |
Cohort Profile: ZOE 2.0—A Community-Based Genetic Epidemiologic Study of Early Childhood Oral Health |
title_full_unstemmed |
Cohort Profile: ZOE 2.0—A Community-Based Genetic Epidemiologic Study of Early Childhood Oral Health |
title_sort |
cohort profile: zoe 2.0—a community-based genetic epidemiologic study of early childhood oral health |
publisher |
MDPI AG |
series |
International Journal of Environmental Research and Public Health |
issn |
1661-7827 1660-4601 |
publishDate |
2020-11-01 |
description |
Early childhood caries (ECC) is an aggressive form of dental caries occurring in the first five years of life. Despite its prevalence and consequences, little progress has been made in its prevention and even less is known about individuals’ susceptibility or genomic risk factors. The genome-wide association study (GWAS) of ECC (“ZOE 2.0”) is a community-based, multi-ethnic, cross-sectional, genetic epidemiologic study seeking to address this knowledge gap. This paper describes the study’s design, the cohort’s demographic profile, data domains, and key oral health outcomes. Between 2016 and 2019, the study enrolled 8059 3–5-year-old children attending public preschools in North Carolina, United States. Participants resided in 86 of the state’s 100 counties and racial/ethnic minorities predominated—for example, 48% (<i>n</i> = 3872) were African American, 22% white, and 20% (<i>n</i> = 1611) were Hispanic/Latino. Seventy-nine percent (<i>n</i> = 6404) of participants underwent clinical dental examinations yielding ECC outcome measures—ECC (defined at the established caries lesion threshold) prevalence was 54% and the mean number of decayed, missing, filled surfaces due to caries was eight. Nearly all (98%) examined children provided sufficient DNA from saliva for genotyping. The cohort’s community-based nature and rich data offer excellent opportunities for addressing important clinical, epidemiologic, and biological questions in early childhood. |
topic |
children early childhood caries community-based studies oral health genomics |
url |
https://www.mdpi.com/1660-4601/17/21/8056 |
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doaj-ddd27c4c857149a3afefd21be14b54f02020-11-25T03:56:34ZengMDPI AGInternational Journal of Environmental Research and Public Health1661-78271660-46012020-11-01178056805610.3390/ijerph17218056Cohort Profile: ZOE 2.0—A Community-Based Genetic Epidemiologic Study of Early Childhood Oral HealthKimon Divaris0Gary D. Slade1Andrea G. Ferreira Zandona2John S. Preisser3Jeannie Ginnis4Miguel A. Simancas-Pallares5Cary S. Agler6Poojan Shrestha7Deepti S. Karhade8Apoena de Aguiar Ribeiro9Hunyong Cho10Yu Gu11Beau D. Meyer12Ashwini R. Joshi13M. Andrea Azcarate-Peril14Patricia V. Basta15Di Wu16Kari E. North17Division of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina-Chapel Hill, NC 27599-7450, USADivision of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina-Chapel Hill, NC 27599-7450, USADepartment of Comprehensive Dentistry, School of Dental Medicine, Tufts University, Boston, MA 02111, USADepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, NC 27599-7400, USADivision of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina-Chapel Hill, NC 27599-7450, USADivision of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina-Chapel Hill, NC 27599-7450, USADivision of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina-Chapel Hill, NC 27599-7450, USADivision of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina-Chapel Hill, NC 27599-7450, USADivision of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina-Chapel Hill, NC 27599-7450, USADivision of Diagnostic Sciences, Adams School of Dentistry, University of North Carolina-Chapel Hill, NC 27599-7450, USADepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, NC 27599-7400, USADepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, NC 27599-7400, USADivision of Pediatric Dentistry, College of Dentistry, The Ohio State University, Columbus, OH 43210, USADivision of Surgery, School of Medicine, University of North Carolina-Chapel Hill, NC 27599-7050, USACenter for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, and UNC Microbiome Core, Department of Medicine, School of Medicine, University of North Carolina-Chapel Hill, NC 27599-7555, USADepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, NC 27599-7400, USADepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, NC 27599-7400, USADepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, NC 27599-7400, USAEarly childhood caries (ECC) is an aggressive form of dental caries occurring in the first five years of life. Despite its prevalence and consequences, little progress has been made in its prevention and even less is known about individuals’ susceptibility or genomic risk factors. The genome-wide association study (GWAS) of ECC (“ZOE 2.0”) is a community-based, multi-ethnic, cross-sectional, genetic epidemiologic study seeking to address this knowledge gap. This paper describes the study’s design, the cohort’s demographic profile, data domains, and key oral health outcomes. Between 2016 and 2019, the study enrolled 8059 3–5-year-old children attending public preschools in North Carolina, United States. Participants resided in 86 of the state’s 100 counties and racial/ethnic minorities predominated—for example, 48% (<i>n</i> = 3872) were African American, 22% white, and 20% (<i>n</i> = 1611) were Hispanic/Latino. Seventy-nine percent (<i>n</i> = 6404) of participants underwent clinical dental examinations yielding ECC outcome measures—ECC (defined at the established caries lesion threshold) prevalence was 54% and the mean number of decayed, missing, filled surfaces due to caries was eight. Nearly all (98%) examined children provided sufficient DNA from saliva for genotyping. The cohort’s community-based nature and rich data offer excellent opportunities for addressing important clinical, epidemiologic, and biological questions in early childhood.https://www.mdpi.com/1660-4601/17/21/8056childrenearly childhood cariescommunity-based studiesoral healthgenomics |