Comparison of the Effects of Myrtus Communis L, Berberis Vulgaris and Metronidazole Vaginal Gel alone for the Treatment of Bacterial Vaginosis
Introduction: There is a growing tendency towards herbal medicines for treatment of vaginitis. Antibacterial and antifungal effects of Myrtus communis L and Berberis vulgaris have been demonstrated invitro and invivo. Aim: This study aimed to compare the therapeutic effects of the vaginal gel o...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
JCDR Research and Publications Private Limited
2016-03-01
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Series: | Journal of Clinical and Diagnostic Research |
Subjects: | |
Online Access: | https://jcdr.net/articles/PDF/7392/17211_CE[Ra]_F(Sh)_PF1(BMAK)_PFA(AK)_PF2(PAG).pdf |
Summary: | Introduction: There is a growing tendency towards herbal
medicines for treatment of vaginitis. Antibacterial and antifungal
effects of Myrtus communis L and Berberis vulgaris have been
demonstrated invitro and invivo.
Aim: This study aimed to compare the therapeutic effects of
the vaginal gel of Berberis vulgaris 5% (in metronidazole base)
and Myrtus communis L 2% (in metronidazole base) with only
metronidazole vaginal gel 0.75% on bacterial vaginosis.
Materials and Methods: This study was a randomized clinical
trial research on 120 married women aged 18-40 years affected
by bacterial vaginosis attended for treatment to gynaecology
clinic of Hajar Hospital (Shahrekord, Iran). They were randomly
divided into three groups of 40 participants. Diagnostic criteria
were Amsel's criteria. Myrtus communis L, Berberis vulgaris
vaginal gel or metronidazole vaginal gel for five-night usage
were prescribed to each group, and after 7 days therapeutic
effects were assessed. Data analysis was performed using
ANOVA and Chi-square tests.
Results: A statistically significant difference was observed with
regard to treatment response among the study groups (p<0.001),
with Myrtus communis L and Berberis vulgaris groups having a
better response than metronidazole gel alone. Moreover, there
was no significant difference between Myrtus communis L and
Berberis vulgaris groups (p= 0.18). The patients in groups of
Myrtus communis L or Berberis vulgaris in metronidazole base
did not experience any relapse, but in metronidazole group,
30% of patients experienced relapse during three weeks follow
up.
Conclusion: Findings of the study showed that treatment with
a combination of Myrtus communis L or Berberis vulgaris in
metronidazole base improve the efficacy of bacterial vaginosis
therapy. |
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ISSN: | 2249-782X 0973-709X |