Impact of Cardiovascular Risk Factors on the Occurrence of Cardiovascular Events in Antineutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitides
Despite improvement in the prognosis of ANCA-associated vasculitides (AAVs), increased mortality, mainly from a cardiovascular origin, persists. We aimed to determine the role of cardiovascular risk factors (CVRFs) on the occurrence of major cardiovascular events (MACEs) in AAVs. Patients with AAVs...
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doaj-dddf982b3066469fad7d5e04af8974a82021-06-01T01:04:38ZengMDPI AGJournal of Clinical Medicine2077-03832021-05-01102299229910.3390/jcm10112299Impact of Cardiovascular Risk Factors on the Occurrence of Cardiovascular Events in Antineutrophil Cytoplasmic Antibody (ANCA)-Associated VasculitidesCamille Roubille0Soledad Henriquez1Cédric Mercuzot2Claire Duflos3Bertrand Dunogue4Karine Briot5Loic Guillevin6Benjamin Terrier7Pierre Fesler8Department of Internal Medicine, Lapeyronie Hospital, Montpellier University Hospital, 34000 Montpellier, FranceDepartment of Internal Medicine, Assistance Publique Hôpitaux de Paris-Centre, Université de Paris, Hôpital Cochin, 75014 Paris, FranceDepartment of Internal Medicine, Lapeyronie Hospital, Montpellier University Hospital, 34000 Montpellier, FranceClinical Research and Epidemiology Unit, Medical Information Department, Lapeyronie Hospital, Montpellier University Hospital, 34000 Montpellier, FranceDepartment of Internal Medicine, Assistance Publique Hôpitaux de Paris-Centre, Université de Paris, Hôpital Cochin, 75014 Paris, FranceUniversité de Paris, 75006 Paris, FranceDepartment of Internal Medicine, Assistance Publique Hôpitaux de Paris-Centre, Université de Paris, Hôpital Cochin, 75014 Paris, FranceDepartment of Internal Medicine, Assistance Publique Hôpitaux de Paris-Centre, Université de Paris, Hôpital Cochin, 75014 Paris, FranceDepartment of Internal Medicine, Lapeyronie Hospital, Montpellier University Hospital, 34000 Montpellier, FranceDespite improvement in the prognosis of ANCA-associated vasculitides (AAVs), increased mortality, mainly from a cardiovascular origin, persists. We aimed to determine the role of cardiovascular risk factors (CVRFs) on the occurrence of major cardiovascular events (MACEs) in AAVs. Patients with AAVs were successively included in a prospective cohort study, which assessed CVRFs (defined by age >50 years in men and >60 years in women, personal history of cardiovascular disease, smoking status, obesity, diabetes, dyslipidemia, hypertension, and sedentary lifestyle), the use of glucocorticoids and immunosuppressive agents at baseline and during follow-up, and the occurrence of MACEs. One hundred and three patients were included, with a median follow-up time of 3.5 years. In the glucocorticoids and cyclophosphamide adjusted multivariate analysis, the occurrence of MACEs was associated with older age (<i>p</i> = 0.001, OR = 14.71, 95% CI (confidence interval) = 2.98–72.68), cardiovascular history (<i>p</i> = 0.007, OR (odds ratio) = 6.54, 95% CI = 1.66–25.71), sedentary lifestyle (<i>p</i> = 0.011, OR = 4.50, 95% CI = 1.42–14.29), hypertension (<i>p</i> = 0.017, OR = 5.04, 95% CI = 1.33–19.12), and dyslipidemia (<i>p</i> = 0.03, OR = 3.86, 95% CI = 1.14–13.09). The occurrence of MACEs was associated with the number of CVRFs (<i>p</i> < 0.001), but not with the use of glucocorticoids or cyclophosphamide (<i>p</i> = 0.733 and <i>p</i> = 0.339, respectively). The implementation of a screening and management program for modifiable CVRFs, particularly hypertension, sedentary lifestyle, and dyslipidemia, may be beneficial for AAV patients in order to reduce their cardiovascular risk.https://www.mdpi.com/2077-0383/10/11/2299cardiovascular risk factorsantineutrophil cytoplasmic antibody (ANCA)-associated vasculitiscardiovascular riskhypertensiondyslipidemiasedentary lifestyle |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Camille Roubille Soledad Henriquez Cédric Mercuzot Claire Duflos Bertrand Dunogue Karine Briot Loic Guillevin Benjamin Terrier Pierre Fesler |
spellingShingle |
Camille Roubille Soledad Henriquez Cédric Mercuzot Claire Duflos Bertrand Dunogue Karine Briot Loic Guillevin Benjamin Terrier Pierre Fesler Impact of Cardiovascular Risk Factors on the Occurrence of Cardiovascular Events in Antineutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitides Journal of Clinical Medicine cardiovascular risk factors antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis cardiovascular risk hypertension dyslipidemia sedentary lifestyle |
author_facet |
Camille Roubille Soledad Henriquez Cédric Mercuzot Claire Duflos Bertrand Dunogue Karine Briot Loic Guillevin Benjamin Terrier Pierre Fesler |
author_sort |
Camille Roubille |
title |
Impact of Cardiovascular Risk Factors on the Occurrence of Cardiovascular Events in Antineutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitides |
title_short |
Impact of Cardiovascular Risk Factors on the Occurrence of Cardiovascular Events in Antineutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitides |
title_full |
Impact of Cardiovascular Risk Factors on the Occurrence of Cardiovascular Events in Antineutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitides |
title_fullStr |
Impact of Cardiovascular Risk Factors on the Occurrence of Cardiovascular Events in Antineutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitides |
title_full_unstemmed |
Impact of Cardiovascular Risk Factors on the Occurrence of Cardiovascular Events in Antineutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitides |
title_sort |
impact of cardiovascular risk factors on the occurrence of cardiovascular events in antineutrophil cytoplasmic antibody (anca)-associated vasculitides |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2021-05-01 |
description |
Despite improvement in the prognosis of ANCA-associated vasculitides (AAVs), increased mortality, mainly from a cardiovascular origin, persists. We aimed to determine the role of cardiovascular risk factors (CVRFs) on the occurrence of major cardiovascular events (MACEs) in AAVs. Patients with AAVs were successively included in a prospective cohort study, which assessed CVRFs (defined by age >50 years in men and >60 years in women, personal history of cardiovascular disease, smoking status, obesity, diabetes, dyslipidemia, hypertension, and sedentary lifestyle), the use of glucocorticoids and immunosuppressive agents at baseline and during follow-up, and the occurrence of MACEs. One hundred and three patients were included, with a median follow-up time of 3.5 years. In the glucocorticoids and cyclophosphamide adjusted multivariate analysis, the occurrence of MACEs was associated with older age (<i>p</i> = 0.001, OR = 14.71, 95% CI (confidence interval) = 2.98–72.68), cardiovascular history (<i>p</i> = 0.007, OR (odds ratio) = 6.54, 95% CI = 1.66–25.71), sedentary lifestyle (<i>p</i> = 0.011, OR = 4.50, 95% CI = 1.42–14.29), hypertension (<i>p</i> = 0.017, OR = 5.04, 95% CI = 1.33–19.12), and dyslipidemia (<i>p</i> = 0.03, OR = 3.86, 95% CI = 1.14–13.09). The occurrence of MACEs was associated with the number of CVRFs (<i>p</i> < 0.001), but not with the use of glucocorticoids or cyclophosphamide (<i>p</i> = 0.733 and <i>p</i> = 0.339, respectively). The implementation of a screening and management program for modifiable CVRFs, particularly hypertension, sedentary lifestyle, and dyslipidemia, may be beneficial for AAV patients in order to reduce their cardiovascular risk. |
topic |
cardiovascular risk factors antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis cardiovascular risk hypertension dyslipidemia sedentary lifestyle |
url |
https://www.mdpi.com/2077-0383/10/11/2299 |
work_keys_str_mv |
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