Loss of PINK1 increases the heart's vulnerability to ischemia-reperfusion injury.
Mutations in PTEN inducible kinase-1 (PINK1) induce mitochondrial dysfunction in dopaminergic neurons resulting in an inherited form of Parkinson's disease. Although PINK1 is present in the heart its exact role there is unclear. We hypothesized that PINK1 protects the heart against acute ischem...
Main Authors: | Hilary K Siddall, Derek M Yellon, Sang-Bing Ong, Uma A Mukherjee, Niall Burke, Andrew R Hall, Plamena R Angelova, Marthe H R Ludtmann, Emma Deas, Sean M Davidson, Mihaela M Mocanu, Derek J Hausenloy |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3639249?pdf=render |
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