A Study of the Short and Long-term Regulation of E. coli Metabolic Pathways

The present study addresses the regulatory network of Escherichia coli and offers a global view of the short- and long-term regulation of its metabolic pathways. The regulatory mechanisms responsible for key metabolic activities and the structure behind such mechanisms are detailed. Most metabolic f...

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Main Authors:	Lourenço Anália, Carneiro Sónia, Pinto José P., Rocha Miguel, Ferreira Eugénio C., Rocha Isabel
Format:	Article
Language:	English
Published:	De Gruyter 2011-12-01
Series:	Journal of Integrative Bioinformatics
Online Access:	https://doi.org/10.1515/jib-2011-183

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spelling	doaj-ddec11022b4d43eca09b053cc2a5e8522021-09-06T19:40:31ZengDe GruyterJournal of Integrative Bioinformatics1613-45162011-12-018319520910.1515/jib-2011-183biecoll-jib-2011-183A Study of the Short and Long-term Regulation of E. coli Metabolic PathwaysLourenço Anália0Carneiro Sónia1Pinto José P.2Rocha Miguel3Ferreira Eugénio C.4Rocha Isabel5Institute for Biotechnology and Bioengineering, Centre of Biological, Engineering, University of Minho, Campus de Gualtar, 4710-057, Braga, PortugalInstitute for Biotechnology and Bioengineering, Centre of Biological, Engineering, University of Minho, Campus de Gualtar, 4710-057, Braga, PortugalDepartment of Informatics/CCTC, University of Minho, Campus de Gualtar, 4710-057, Braga, PortugalDepartment of Informatics/CCTC, University of Minho, Campus de Gualtar, 4710-057, Braga, PortugalInstitute for Biotechnology and Bioengineering, Centre of Biological, Engineering, University of Minho, Campus de Gualtar, 4710-057, Braga, PortugalInstitute for Biotechnology and Bioengineering, Centre of Biological, Engineering, University of Minho, Campus de Gualtar, 4710-057, Braga, PortugalThe present study addresses the regulatory network of Escherichia coli and offers a global view of the short- and long-term regulation of its metabolic pathways. The regulatory mechanisms responsible for key metabolic activities and the structure behind such mechanisms are detailed. Most metabolic functions are dependent on the activity of transcriptional regulators over gene expression - the so-called long-term regulation. However, enzymatic regulation - the so-called short-term regulation - often overlays transcriptional regulation and even, in particular metabolic pathways, enzymatic regulation may prevail. As such, understanding the balance between these two types of regulation is necessary to be able to predict and control cell responses, specifically cell responses to the various environmental stresses.https://doi.org/10.1515/jib-2011-183
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Lourenço Anália Carneiro Sónia Pinto José P. Rocha Miguel Ferreira Eugénio C. Rocha Isabel
spellingShingle	Lourenço Anália Carneiro Sónia Pinto José P. Rocha Miguel Ferreira Eugénio C. Rocha Isabel A Study of the Short and Long-term Regulation of E. coli Metabolic Pathways Journal of Integrative Bioinformatics
author_facet	Lourenço Anália Carneiro Sónia Pinto José P. Rocha Miguel Ferreira Eugénio C. Rocha Isabel
author_sort	Lourenço Anália
title	A Study of the Short and Long-term Regulation of E. coli Metabolic Pathways
title_short	A Study of the Short and Long-term Regulation of E. coli Metabolic Pathways
title_full	A Study of the Short and Long-term Regulation of E. coli Metabolic Pathways
title_fullStr	A Study of the Short and Long-term Regulation of E. coli Metabolic Pathways
title_full_unstemmed	A Study of the Short and Long-term Regulation of E. coli Metabolic Pathways
title_sort	study of the short and long-term regulation of e. coli metabolic pathways
publisher	De Gruyter
series	Journal of Integrative Bioinformatics
issn	1613-4516
publishDate	2011-12-01
description	The present study addresses the regulatory network of Escherichia coli and offers a global view of the short- and long-term regulation of its metabolic pathways. The regulatory mechanisms responsible for key metabolic activities and the structure behind such mechanisms are detailed. Most metabolic functions are dependent on the activity of transcriptional regulators over gene expression - the so-called long-term regulation. However, enzymatic regulation - the so-called short-term regulation - often overlays transcriptional regulation and even, in particular metabolic pathways, enzymatic regulation may prevail. As such, understanding the balance between these two types of regulation is necessary to be able to predict and control cell responses, specifically cell responses to the various environmental stresses.
url	https://doi.org/10.1515/jib-2011-183
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A Study of the Short and Long-term Regulation of E. coli Metabolic Pathways

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