Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria

Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria

In Plasmodium falciparum malaria, CD8+ T cells play a double-edged role. Liver-stage specific CD8+ T cells can confer protection, as has been shown in several vaccine studies. Blood-stage specific CD8+ T cells, on the other hand, contribute to the development of cerebral malaria in murine models of...

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Bibliographic Details
Main Authors: Lea-Christina Kaminski, Mathias Riehn, Annemieke Abel, Christiane Steeg, Denis Dekugmen Yar, Otchere Addai-Mensah, Francis Aminkiah, Ellis Owusu Dabo, Thomas Jacobs, Maria Sophia Mackroth
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Immunology
Subjects:
granzyme B
CD8+ T cells
malaria
severe malaria
Plasmodium falciparum
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02917/full

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