Determination of Etelcalcetide Biotransformation and Hemodialysis Kinetics to Guide the Timing of Its Dosing
Etelcalcetide, a novel calcimimetic agonist of the calcium-sensing receptor for treatment of secondary hyperparathyroidism in chronic kidney disease patients on hemodialysis, is a d-amino acid linear heptapeptide with a d-cysteine that is linked to an l-cysteine by a disulfide bond. In addition to b...
Main Authors: | Katheryne Z. Edson, Benjamin M. Wu, Abhinaya Iyer, William Goodman, Gary L. Skiles, Raju Subramanian |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2016-05-01
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Series: | Kidney International Reports |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2468024916300031 |
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