Mechanochemical Lignin-Mediated Strecker Reaction

Mechanochemical Lignin-Mediated Strecker Reaction

A mechanochemical Strecker reaction involving a wide range of aldehydes (aromatic, heteroaromatic and aliphatic), amines, and KCN afforded a library of α-aminonitriles upon mechanical activation. This multicomponent process was efficiently activated by lignocellulosic biomass as additives. Particula...

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Bibliographic Details
Main Authors: Saumya Dabral, Mathias Turberg, Andrea Wanninger, Carsten Bolm, José G. Hernández
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:Molecules
Subjects:
mechanochemistry
lignin
Strecker reaction
multicomponent reactions
ball milling
Online Access:http://www.mdpi.com/1420-3049/22/1/146
Description
Summary:A mechanochemical Strecker reaction involving a wide range of aldehydes (aromatic, heteroaromatic and aliphatic), amines, and KCN afforded a library of α-aminonitriles upon mechanical activation. This multicomponent process was efficiently activated by lignocellulosic biomass as additives. Particularly, commercially available Kraft lignin was found to be the best activator for the addition of cyanide to the in situ formed imines. A comparative study of the 31P-NMR (Nuclear Magnetic Resonance) along with IR (Infrared) data analysis for the Kraft lignin and methylated Kraft lignin samples ascertained the importance of the free hydroxyl groups in the activation of the mechanochemical reaction. The solvent-free mechanochemical Strecker reaction was then coupled with a lactamization process leading to the formation of the N-benzylphthalimide (5a) and the isoindolinone derivative 6a.
ISSN:1420-3049

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