Ginsenoside Rh2 inhibiting HCT116 colon cancer cell proliferation through blocking PDZ-binding kinase/T-LAK cell-originated protein kinase

Ginsenoside Rh2 inhibiting HCT116 colon cancer cell proliferation through blocking PDZ-binding kinase/T-LAK cell-originated protein kinase

Background: Ginsenoside Rh2 (GRh2) is the main bioactive component in American ginseng, a commonly used herb, and its antitumor activity had been studied in previous studies. PDZ-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK), a serine/threonine protein kinase, is highly expressed in...

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Bibliographic Details
Main Authors: Jianjun Yang, Donghong Yuan, Tongchao Xing, Hongli Su, Shengjun Zhang, Jiansheng Wen, Qiqiang Bai, Dongmei Dang
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Journal of Ginseng Research
Subjects:
antitumor effect
apoptosis
ginsenoside Rh2
HCT116 colorectal cancer cells
PDZ-binding kinase/T-LAK cell-originated protein kinase
Online Access:http://www.sciencedirect.com/science/article/pii/S1226845316300331

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