Freezing of gait and dementia in parkinsonism: A retrospective case–control study
Abstract Objectives To support the cognitive model of Freezing of Gait (FoG) we investigated FoG in a cohort of patients with Dementia with Lewy Bodies (DLB). Materials and Methods We assessed FoG frequency in 19 DLB patients compared to 19 control PD patients within 2 years from symptom onset and w...
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doaj-ddfcb4e2e6c646c9b3bba97988ca65e62020-11-25T03:31:56ZengWileyBrain and Behavior2162-32792019-06-0196n/an/a10.1002/brb3.1247Freezing of gait and dementia in parkinsonism: A retrospective case–control studyGiovanni Palermo0Daniela Frosini1Andrea Corsi2Martina Giuntini3Sonia Mazzucchi4Eleonora Del Prete5Ubaldo Bonuccelli6Roberto Ceravolo7Department of Clinical and Experimental Medicine, Unit of Neurology University of Pisa Pisa ItalyDepartment of Clinical and Experimental Medicine, Unit of Neurology University of Pisa Pisa ItalyDepartment of Clinical and Experimental Medicine, Unit of Neurology University of Pisa Pisa ItalyDepartment of Clinical and Experimental Medicine, Unit of Neurology University of Pisa Pisa ItalyDepartment of Clinical and Experimental Medicine, Unit of Neurology University of Pisa Pisa ItalyDepartment of Clinical and Experimental Medicine, Unit of Neurology University of Pisa Pisa ItalyDepartment of Clinical and Experimental Medicine, Unit of Neurology University of Pisa Pisa ItalyDepartment of Clinical and Experimental Medicine, Unit of Neurology University of Pisa Pisa ItalyAbstract Objectives To support the cognitive model of Freezing of Gait (FoG) we investigated FoG in a cohort of patients with Dementia with Lewy Bodies (DLB). Materials and Methods We assessed FoG frequency in 19 DLB patients compared to 19 control PD patients within 2 years from symptom onset and with at least 5 years follow‐up. The two groups were matched by age and motor presentation at onset, severity of parkinsonism and disease duration. The presence and severity of FoG was identified as those with a score of 1 or greater on subitem 14 of the Unified Parkinson's Disease Rating Scale Part II (UPDRS II). Results At T0, 68.4% DLB and 10.5% PD patients experienced FoG ≥1. The prevalence of FoG increased with disease progression (94.7% DLB and 47.3% PD subjects had FoG ≥1 at T5). DLB also showed a more severe FoG (FoG ≥2) than PD (21% vs. 0% at T0 and 52.6% vs. 10.5% at T5), consistently with previous studies reporting FoG prevalence in DLB. Conclusion This is the first study looking specifically at FoG in DLB, identifying it as a frequent and early feature of DLB and emphasizing the crucial role of cognitive impairment in the occurrence of this mysterious phenomenon.https://doi.org/10.1002/brb3.1247dementia with lewy bodiesfreezing of gaitParkinsonismParkinson's disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Giovanni Palermo Daniela Frosini Andrea Corsi Martina Giuntini Sonia Mazzucchi Eleonora Del Prete Ubaldo Bonuccelli Roberto Ceravolo |
spellingShingle |
Giovanni Palermo Daniela Frosini Andrea Corsi Martina Giuntini Sonia Mazzucchi Eleonora Del Prete Ubaldo Bonuccelli Roberto Ceravolo Freezing of gait and dementia in parkinsonism: A retrospective case–control study Brain and Behavior dementia with lewy bodies freezing of gait Parkinsonism Parkinson's disease |
author_facet |
Giovanni Palermo Daniela Frosini Andrea Corsi Martina Giuntini Sonia Mazzucchi Eleonora Del Prete Ubaldo Bonuccelli Roberto Ceravolo |
author_sort |
Giovanni Palermo |
title |
Freezing of gait and dementia in parkinsonism: A retrospective case–control study |
title_short |
Freezing of gait and dementia in parkinsonism: A retrospective case–control study |
title_full |
Freezing of gait and dementia in parkinsonism: A retrospective case–control study |
title_fullStr |
Freezing of gait and dementia in parkinsonism: A retrospective case–control study |
title_full_unstemmed |
Freezing of gait and dementia in parkinsonism: A retrospective case–control study |
title_sort |
freezing of gait and dementia in parkinsonism: a retrospective case–control study |
publisher |
Wiley |
series |
Brain and Behavior |
issn |
2162-3279 |
publishDate |
2019-06-01 |
description |
Abstract Objectives To support the cognitive model of Freezing of Gait (FoG) we investigated FoG in a cohort of patients with Dementia with Lewy Bodies (DLB). Materials and Methods We assessed FoG frequency in 19 DLB patients compared to 19 control PD patients within 2 years from symptom onset and with at least 5 years follow‐up. The two groups were matched by age and motor presentation at onset, severity of parkinsonism and disease duration. The presence and severity of FoG was identified as those with a score of 1 or greater on subitem 14 of the Unified Parkinson's Disease Rating Scale Part II (UPDRS II). Results At T0, 68.4% DLB and 10.5% PD patients experienced FoG ≥1. The prevalence of FoG increased with disease progression (94.7% DLB and 47.3% PD subjects had FoG ≥1 at T5). DLB also showed a more severe FoG (FoG ≥2) than PD (21% vs. 0% at T0 and 52.6% vs. 10.5% at T5), consistently with previous studies reporting FoG prevalence in DLB. Conclusion This is the first study looking specifically at FoG in DLB, identifying it as a frequent and early feature of DLB and emphasizing the crucial role of cognitive impairment in the occurrence of this mysterious phenomenon. |
topic |
dementia with lewy bodies freezing of gait Parkinsonism Parkinson's disease |
url |
https://doi.org/10.1002/brb3.1247 |
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