Sex hormone-binding globulin, androgens and mortality: the KORA-F4 cohort study
Objective: Sex hormone-binding globulin (SHBG) and androgens have been associated with mortality in women and men, but controversy still exists. Our objective was to investigate associations of SHBG and androgens with all-cause a nd cause-specific mortality in men and women. Design: 1006 men and 7...
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Bioscientifica
2020-04-01
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doaj-ddfd8cfe10f241218cad20ccd4a43d1c2020-11-25T02:22:56ZengBioscientificaEndocrine Connections2049-36142049-36142020-04-0194326336https://doi.org/10.1530/EC-20-0080Sex hormone-binding globulin, androgens and mortality: the KORA-F4 cohort studyFlorian Schederecker0Alexander Cecil1Cornelia Prehn2Jana Nano3Wolfgang Koenig4Jerzy Adamski5Tanja Zeller6Annette Peters7Barbara Thorand8Institute of Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Neuherberg, GermanyMolecular Endocrinology and Metabolism, Genome Analysis Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, GermanyMolecular Endocrinology and Metabolism, Genome Analysis Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, GermanyInstitute of Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Neuherberg, GermanyInstitute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany; Deutsches Herzzentrum München, Technische Universität München, DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, GermanyMolecular Endocrinology and Metabolism, Genome Analysis Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Lehrstuhl für Experimentelle Genetik, Technische Universität München, Freising-Weihenstephan, Germany; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeDepartment of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, GermanyInstitute of Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Neuherberg, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Munich, Munich, GermanyInstitute of Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Neuherberg, GermanyObjective: Sex hormone-binding globulin (SHBG) and androgens have been associated with mortality in women and men, but controversy still exists. Our objective was to investigate associations of SHBG and androgens with all-cause a nd cause-specific mortality in men and women. Design: 1006 men and 709 peri- and postmenopausal women (age range: 45–82 years) from the German population-based KORA F4 cohort study were followed-up for a median of 8.7 years. Methods: SHBG was measured with an immunoassay, total testosterone (TT) and dihydrotestosterone (DHT) with mass-spectrometry in serum samples and we calculated free testosterone (cFT). To assess associations between SHBG and androgen levels and mortality, we calculated hazard ratios (HRs) with 95% CIs using Cox proportional-hazards models. Results: In the cohort, 128 men (12.7%) and 70 women (9.9%) died. In women, we observed positive associations of SHBG with all-cause (HR: 1.54, 95% CI: 1.16–2.04) and with other disease-related mortality (HR: 1.86, 95% CI: 1.08–3.20) and for DHT with all-cause mortality (HR: 1.32, 95% CI: 1.00–1.73). In men, we found a positive association of SHBG (HR: 1.24 95% CI: 1.00–1.54) and inverse associations of TT (HR: 0.87, 95% CI: 0.77–0.97) and cFT (HR: 0.84, 95% CI: 0.73–0.97) with all-cause mortality. No other associations were found for cause-specific mortality. Conclusions: Higher SHBG levels were associated with increased risk of all-cause mortality in men and women. Lower TT and cFT levels in men and higher DHT levels in women were associated with increased risk of all-cause mortality. Future, well-powered population-based studies should further investigate cause-specific mortality risk. https://ec.bioscientifica.com/view/journals/ec/9/4/EC-20-0080.xmlshbgtestosteronedhtandrogensmortality |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Florian Schederecker Alexander Cecil Cornelia Prehn Jana Nano Wolfgang Koenig Jerzy Adamski Tanja Zeller Annette Peters Barbara Thorand |
spellingShingle |
Florian Schederecker Alexander Cecil Cornelia Prehn Jana Nano Wolfgang Koenig Jerzy Adamski Tanja Zeller Annette Peters Barbara Thorand Sex hormone-binding globulin, androgens and mortality: the KORA-F4 cohort study Endocrine Connections shbg testosterone dht androgens mortality |
author_facet |
Florian Schederecker Alexander Cecil Cornelia Prehn Jana Nano Wolfgang Koenig Jerzy Adamski Tanja Zeller Annette Peters Barbara Thorand |
author_sort |
Florian Schederecker |
title |
Sex hormone-binding globulin, androgens and mortality: the KORA-F4 cohort study |
title_short |
Sex hormone-binding globulin, androgens and mortality: the KORA-F4 cohort study |
title_full |
Sex hormone-binding globulin, androgens and mortality: the KORA-F4 cohort study |
title_fullStr |
Sex hormone-binding globulin, androgens and mortality: the KORA-F4 cohort study |
title_full_unstemmed |
Sex hormone-binding globulin, androgens and mortality: the KORA-F4 cohort study |
title_sort |
sex hormone-binding globulin, androgens and mortality: the kora-f4 cohort study |
publisher |
Bioscientifica |
series |
Endocrine Connections |
issn |
2049-3614 2049-3614 |
publishDate |
2020-04-01 |
description |
Objective: Sex hormone-binding globulin (SHBG) and androgens have been associated with mortality in women and men, but controversy still exists. Our objective was to investigate associations of SHBG and androgens with all-cause a nd cause-specific mortality in men and women.
Design: 1006 men and 709 peri- and postmenopausal women (age range: 45–82 years) from the German population-based KORA F4 cohort study were followed-up for a median of 8.7 years.
Methods: SHBG was measured with an immunoassay, total testosterone (TT) and dihydrotestosterone (DHT) with mass-spectrometry in serum samples and we calculated free testosterone (cFT). To assess associations between SHBG and androgen levels and mortality, we calculated hazard ratios (HRs) with 95% CIs using Cox proportional-hazards models.
Results: In the cohort, 128 men (12.7%) and 70 women (9.9%) died. In women, we observed positive associations of SHBG with all-cause (HR: 1.54, 95% CI: 1.16–2.04) and with other disease-related mortality (HR: 1.86, 95% CI: 1.08–3.20) and for DHT with all-cause mortality (HR: 1.32, 95% CI: 1.00–1.73). In men, we found a positive association of SHBG (HR: 1.24 95% CI: 1.00–1.54) and inverse associations of TT (HR: 0.87, 95% CI: 0.77–0.97) and cFT (HR: 0.84, 95% CI: 0.73–0.97) with all-cause mortality. No other associations were found for cause-specific mortality.
Conclusions: Higher SHBG levels were associated with increased risk of all-cause mortality in men and women. Lower TT and cFT levels in men and higher DHT levels in women were associated with increased risk of all-cause mortality. Future, well-powered population-based studies should further investigate cause-specific mortality risk.
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topic |
shbg testosterone dht androgens mortality |
url |
https://ec.bioscientifica.com/view/journals/ec/9/4/EC-20-0080.xml |
work_keys_str_mv |
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