Male germ cells support long-term propagation of Zika virus
Zika virus (ZIKV) can persist for months in semen and sperm. Here, the authors show that germ cells, compared to other cell types in the reproductive tract, are most susceptible to ZIKV and produce high levels of progeny virus, which coincides with decreased expression of the interferon-stimulated g...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2018-05-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-04444-w |
| id |
doaj-de04bd349fab404aa0fe17716eae5931 |
|---|---|
| record_format |
Article |
| spelling |
doaj-de04bd349fab404aa0fe17716eae59312021-05-11T09:45:49ZengNature Publishing GroupNature Communications2041-17232018-05-019111110.1038/s41467-018-04444-wMale germ cells support long-term propagation of Zika virusChristopher L. Robinson0Angie C. N. Chong1Alison W. Ashbrook2Ginnie Jeng3Julia Jin4Haiqi Chen5Elizabeth I. Tang6Laura A. Martin7Rosa S. Kim8Reyn M. Kenyon9Eileen Do10Joseph M. Luna11Mohsan Saeed12Lori Zeltser13Harold Ralph14Vanessa L. Dudley15Marc Goldstein16Charles M. Rice17C. Yan Cheng18Marco Seandel19Shuibing Chen20Department of Surgery, Weill Cornell Medical CollegeDepartment of Surgery, Weill Cornell Medical CollegeLaboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller UniversityDepartment of Surgery, Weill Cornell Medical CollegeDepartment of Surgery, Weill Cornell Medical CollegeThe Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population CouncilThe Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population CouncilDepartment of Surgery, Weill Cornell Medical CollegePenn State College of MedicineDepartment of Surgery, Weill Cornell Medical CollegeDepartment of Surgery, Weill Cornell Medical CollegeLaboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller UniversityLaboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller UniversityNaomi Berrie Diabetes Center, Columbia UniversityWeill Cornell Medical College-Microscopy and Image Analysis Core FacilityInstitute of Reproductive Medicine at Weill Cornell Medicine, Weill Cornell Medicine–New York Presbyterian HospitalDepartment of Urology and Institute for Reproductive Medicine, Weill Cornell Medical College of Cornell UniversityLaboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller UniversityThe Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population CouncilDepartment of Surgery, Weill Cornell Medical CollegeDepartment of Surgery, Weill Cornell Medical CollegeZika virus (ZIKV) can persist for months in semen and sperm. Here, the authors show that germ cells, compared to other cell types in the reproductive tract, are most susceptible to ZIKV and produce high levels of progeny virus, which coincides with decreased expression of the interferon-stimulated gene Ifi44l.https://doi.org/10.1038/s41467-018-04444-w |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Christopher L. Robinson Angie C. N. Chong Alison W. Ashbrook Ginnie Jeng Julia Jin Haiqi Chen Elizabeth I. Tang Laura A. Martin Rosa S. Kim Reyn M. Kenyon Eileen Do Joseph M. Luna Mohsan Saeed Lori Zeltser Harold Ralph Vanessa L. Dudley Marc Goldstein Charles M. Rice C. Yan Cheng Marco Seandel Shuibing Chen |
| spellingShingle |
Christopher L. Robinson Angie C. N. Chong Alison W. Ashbrook Ginnie Jeng Julia Jin Haiqi Chen Elizabeth I. Tang Laura A. Martin Rosa S. Kim Reyn M. Kenyon Eileen Do Joseph M. Luna Mohsan Saeed Lori Zeltser Harold Ralph Vanessa L. Dudley Marc Goldstein Charles M. Rice C. Yan Cheng Marco Seandel Shuibing Chen Male germ cells support long-term propagation of Zika virus Nature Communications |
| author_facet |
Christopher L. Robinson Angie C. N. Chong Alison W. Ashbrook Ginnie Jeng Julia Jin Haiqi Chen Elizabeth I. Tang Laura A. Martin Rosa S. Kim Reyn M. Kenyon Eileen Do Joseph M. Luna Mohsan Saeed Lori Zeltser Harold Ralph Vanessa L. Dudley Marc Goldstein Charles M. Rice C. Yan Cheng Marco Seandel Shuibing Chen |
| author_sort |
Christopher L. Robinson |
| title |
Male germ cells support long-term propagation of Zika virus |
| title_short |
Male germ cells support long-term propagation of Zika virus |
| title_full |
Male germ cells support long-term propagation of Zika virus |
| title_fullStr |
Male germ cells support long-term propagation of Zika virus |
| title_full_unstemmed |
Male germ cells support long-term propagation of Zika virus |
| title_sort |
male germ cells support long-term propagation of zika virus |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-05-01 |
| description |
Zika virus (ZIKV) can persist for months in semen and sperm. Here, the authors show that germ cells, compared to other cell types in the reproductive tract, are most susceptible to ZIKV and produce high levels of progeny virus, which coincides with decreased expression of the interferon-stimulated gene Ifi44l. |
| url |
https://doi.org/10.1038/s41467-018-04444-w |
| work_keys_str_mv |
AT christopherlrobinson malegermcellssupportlongtermpropagationofzikavirus AT angiecnchong malegermcellssupportlongtermpropagationofzikavirus AT alisonwashbrook malegermcellssupportlongtermpropagationofzikavirus AT ginniejeng malegermcellssupportlongtermpropagationofzikavirus AT juliajin malegermcellssupportlongtermpropagationofzikavirus AT haiqichen malegermcellssupportlongtermpropagationofzikavirus AT elizabethitang malegermcellssupportlongtermpropagationofzikavirus AT lauraamartin malegermcellssupportlongtermpropagationofzikavirus AT rosaskim malegermcellssupportlongtermpropagationofzikavirus AT reynmkenyon malegermcellssupportlongtermpropagationofzikavirus AT eileendo malegermcellssupportlongtermpropagationofzikavirus AT josephmluna malegermcellssupportlongtermpropagationofzikavirus AT mohsansaeed malegermcellssupportlongtermpropagationofzikavirus AT lorizeltser malegermcellssupportlongtermpropagationofzikavirus AT haroldralph malegermcellssupportlongtermpropagationofzikavirus AT vanessaldudley malegermcellssupportlongtermpropagationofzikavirus AT marcgoldstein malegermcellssupportlongtermpropagationofzikavirus AT charlesmrice malegermcellssupportlongtermpropagationofzikavirus AT cyancheng malegermcellssupportlongtermpropagationofzikavirus AT marcoseandel malegermcellssupportlongtermpropagationofzikavirus AT shuibingchen malegermcellssupportlongtermpropagationofzikavirus |
| _version_ |
1721449343633850368 |