PM2.5-bound PAHs exposure linked with low plasma insulin-like growth factor 1 levels and reduced child height
Background: Exposure to atmospheric fine particle matter (PM2.5) pollution and the absorbed pollutants is known to contribute to numerous adverse health effects in children including to growth. Objective: The aim of this study was to evaluate exposure levels of atmospheric PM2.5-bound polycyclic aro...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2020-05-01
|
Series: | Environment International |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412019328314 |
id |
doaj-de079a1e57924b95948ea599bd754eaf |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhijun Zeng Xia Huo Qihua Wang Chenyang Wang Machteld N. Hylkema Xijin Xu |
spellingShingle |
Zhijun Zeng Xia Huo Qihua Wang Chenyang Wang Machteld N. Hylkema Xijin Xu PM2.5-bound PAHs exposure linked with low plasma insulin-like growth factor 1 levels and reduced child height Environment International |
author_facet |
Zhijun Zeng Xia Huo Qihua Wang Chenyang Wang Machteld N. Hylkema Xijin Xu |
author_sort |
Zhijun Zeng |
title |
PM2.5-bound PAHs exposure linked with low plasma insulin-like growth factor 1 levels and reduced child height |
title_short |
PM2.5-bound PAHs exposure linked with low plasma insulin-like growth factor 1 levels and reduced child height |
title_full |
PM2.5-bound PAHs exposure linked with low plasma insulin-like growth factor 1 levels and reduced child height |
title_fullStr |
PM2.5-bound PAHs exposure linked with low plasma insulin-like growth factor 1 levels and reduced child height |
title_full_unstemmed |
PM2.5-bound PAHs exposure linked with low plasma insulin-like growth factor 1 levels and reduced child height |
title_sort |
pm2.5-bound pahs exposure linked with low plasma insulin-like growth factor 1 levels and reduced child height |
publisher |
Elsevier |
series |
Environment International |
issn |
0160-4120 |
publishDate |
2020-05-01 |
description |
Background: Exposure to atmospheric fine particle matter (PM2.5) pollution and the absorbed pollutants is known to contribute to numerous adverse health effects in children including to growth. Objective: The aim of this study was to evaluate exposure levels of atmospheric PM2.5-bound polycyclic aromatic hydrocarbons (PAHs) in an electronic waste (e-waste) polluted town, Guiyu, and to investigate the associations between PM2.5-PAH exposure, insulin-like growth factor 1 (IGF-1) levels and child growth. Methods: This study recruited 238 preschool children (3–6 years of age), from November to December 2017, of which 125 were from Guiyu (an e-waste area) and 113 were from Haojiang (a reference area). Levels of daily PM2.5 and PM2.5-bound ∑16 PAHs were assessed to calculate individual chronic daily intakes (CDIs). IGF-1 and IGF-binding protein 3 (IGFBP-3) concentrations in child plasma were also measured. The associations and further mediation effects between exposure to PM2.5 and PM2.5-bound PAHs, child plasma IGF-1 concentration, and child height were explored by multiple linear regression models and mediation effect analysis. Results: Elevated atmospheric PM2.5-bound ∑16 PAHs and PM2.5 levels were observed in Guiyu, and this led to more individual CDIs of the exposed children than the reference (all P < 0.001). The median level of plasma IGF-1 in the exposed group was lower than in the reference group (91.42 ng/mL vs. 103.59 ng/mL, P < 0.01). IGF-1 levels were negatively correlated with CDIs of PM2.5, but not with CDIs of PM2.5-bound ∑16 PAHs after adjustment. An increase of 1 μg/kg of PM2.5 intake per day was associated with a 0.012 cm reduction of child height (95% CI: −0.014, −0.009), and similarly, an elevation of 1 ng/kg of PM2.5-bound ∑16 PAHs intake per day was associated with a 0.022 cm decrease of child height (95% CI: −0.029, −0.015), both after adjustment of several potential confounders (age, gender, family cooking oil, picky eater, eating sweet food, eating fruits or vegetables, parental education level and monthly household income). The decreased plasma IGF-1 concentration mediated 15.8% of the whole effect associated with PM2.5 exposure and 23.9% of the whole effect associated with PM2.5-bound ∑16 PAHs exposure on child height. Conclusion: Exposure to atmospheric PM2.5-bound ∑16 PAHs and PM2.5 is negatively associated with child height, and is linked to reduced IGF-1 levels in plasma. This may suggest a causative negative role of atmospheric PM2.5-bound exposures in child growth. Keywords: Child growth, E-waste exposure, Insulin-like growth factor 1, PM2.5, PM2.5-bound PAHs |
url |
http://www.sciencedirect.com/science/article/pii/S0160412019328314 |
work_keys_str_mv |
AT zhijunzeng pm25boundpahsexposurelinkedwithlowplasmainsulinlikegrowthfactor1levelsandreducedchildheight AT xiahuo pm25boundpahsexposurelinkedwithlowplasmainsulinlikegrowthfactor1levelsandreducedchildheight AT qihuawang pm25boundpahsexposurelinkedwithlowplasmainsulinlikegrowthfactor1levelsandreducedchildheight AT chenyangwang pm25boundpahsexposurelinkedwithlowplasmainsulinlikegrowthfactor1levelsandreducedchildheight AT machteldnhylkema pm25boundpahsexposurelinkedwithlowplasmainsulinlikegrowthfactor1levelsandreducedchildheight AT xijinxu pm25boundpahsexposurelinkedwithlowplasmainsulinlikegrowthfactor1levelsandreducedchildheight |
_version_ |
1724834869038546944 |
spelling |
doaj-de079a1e57924b95948ea599bd754eaf2020-11-25T02:29:01ZengElsevierEnvironment International0160-41202020-05-01138PM2.5-bound PAHs exposure linked with low plasma insulin-like growth factor 1 levels and reduced child heightZhijun Zeng0Xia Huo1Qihua Wang2Chenyang Wang3Machteld N. Hylkema4Xijin Xu5Laboratory of Environmental Medicine and Developmental Toxicology, Shantou University Medical College, Shantou 515041, Guangdong, China; University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Hanzeplein 1, 9713 GZ Groningen, the NetherlandsLaboratory of Environmental Medicine and Developmental Toxicology, Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou 511443, Guangdong, ChinaLaboratory of Environmental Medicine and Developmental Toxicology, Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou 511443, Guangdong, ChinaLaboratory of Environmental Medicine and Developmental Toxicology, Shantou University Medical College, Shantou 515041, Guangdong, ChinaUniversity of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Hanzeplein 1, 9713 GZ Groningen, the NetherlandsLaboratory of Environmental Medicine and Developmental Toxicology, Shantou University Medical College, Shantou 515041, Guangdong, China; Department of Cell Biology and Genetics, Shantou University Medical College, Shantou 515041, Guangdong, China; Corresponding author at: Laboratory of Environmental Medicine and Developmental Toxicology, Shantou University Medical College, 22 Xinling Rd., Shantou 515041, Guangdong, China.Background: Exposure to atmospheric fine particle matter (PM2.5) pollution and the absorbed pollutants is known to contribute to numerous adverse health effects in children including to growth. Objective: The aim of this study was to evaluate exposure levels of atmospheric PM2.5-bound polycyclic aromatic hydrocarbons (PAHs) in an electronic waste (e-waste) polluted town, Guiyu, and to investigate the associations between PM2.5-PAH exposure, insulin-like growth factor 1 (IGF-1) levels and child growth. Methods: This study recruited 238 preschool children (3–6 years of age), from November to December 2017, of which 125 were from Guiyu (an e-waste area) and 113 were from Haojiang (a reference area). Levels of daily PM2.5 and PM2.5-bound ∑16 PAHs were assessed to calculate individual chronic daily intakes (CDIs). IGF-1 and IGF-binding protein 3 (IGFBP-3) concentrations in child plasma were also measured. The associations and further mediation effects between exposure to PM2.5 and PM2.5-bound PAHs, child plasma IGF-1 concentration, and child height were explored by multiple linear regression models and mediation effect analysis. Results: Elevated atmospheric PM2.5-bound ∑16 PAHs and PM2.5 levels were observed in Guiyu, and this led to more individual CDIs of the exposed children than the reference (all P < 0.001). The median level of plasma IGF-1 in the exposed group was lower than in the reference group (91.42 ng/mL vs. 103.59 ng/mL, P < 0.01). IGF-1 levels were negatively correlated with CDIs of PM2.5, but not with CDIs of PM2.5-bound ∑16 PAHs after adjustment. An increase of 1 μg/kg of PM2.5 intake per day was associated with a 0.012 cm reduction of child height (95% CI: −0.014, −0.009), and similarly, an elevation of 1 ng/kg of PM2.5-bound ∑16 PAHs intake per day was associated with a 0.022 cm decrease of child height (95% CI: −0.029, −0.015), both after adjustment of several potential confounders (age, gender, family cooking oil, picky eater, eating sweet food, eating fruits or vegetables, parental education level and monthly household income). The decreased plasma IGF-1 concentration mediated 15.8% of the whole effect associated with PM2.5 exposure and 23.9% of the whole effect associated with PM2.5-bound ∑16 PAHs exposure on child height. Conclusion: Exposure to atmospheric PM2.5-bound ∑16 PAHs and PM2.5 is negatively associated with child height, and is linked to reduced IGF-1 levels in plasma. This may suggest a causative negative role of atmospheric PM2.5-bound exposures in child growth. Keywords: Child growth, E-waste exposure, Insulin-like growth factor 1, PM2.5, PM2.5-bound PAHshttp://www.sciencedirect.com/science/article/pii/S0160412019328314 |