An Update on the Potential of Mesenchymal Stem Cell Therapy for Cutaneous Diseases

An Update on the Potential of Mesenchymal Stem Cell Therapy for Cutaneous Diseases

Mesenchymal stem or stromal cells (MSCs) are nonhematopoietic postnatal stem cells with self-renewal, multipotent differentiation, and potent immunomodulatory and anti-inflammatory capabilities, thus playing an important role in tissue repair and regeneration. Numerous clinical and preclinical studi...

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Main Authors: Yanyun Li, Ziyu Ye, Weiqin Yang, Qunzhou Zhang, Jincheng Zeng
Format: Article
Language:English
Published: Hindawi Limited 2021-01-01
Series:Stem Cells International
Online Access:http://dx.doi.org/10.1155/2021/8834590
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spelling doaj-de0f1cabda99483db08139554dfbac412021-02-15T12:53:12ZengHindawi LimitedStem Cells International1687-966X1687-96782021-01-01202110.1155/2021/88345908834590An Update on the Potential of Mesenchymal Stem Cell Therapy for Cutaneous DiseasesYanyun Li0Ziyu Ye1Weiqin Yang2Qunzhou Zhang3Jincheng Zeng4Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, Guangdong Medical University, Dongguan 523808, ChinaGuangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, Guangdong Medical University, Dongguan 523808, ChinaGuangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, Guangdong Medical University, Dongguan 523808, ChinaDepartment of Oral and Maxillofacial Surgery and Pharmacology, University of Pennsylvania School of Dental Medicine, Philadelphia 19104, USAGuangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, Guangdong Medical University, Dongguan 523808, ChinaMesenchymal stem or stromal cells (MSCs) are nonhematopoietic postnatal stem cells with self-renewal, multipotent differentiation, and potent immunomodulatory and anti-inflammatory capabilities, thus playing an important role in tissue repair and regeneration. Numerous clinical and preclinical studies have demonstrated the potential application of MSCs in the treatment of tissue inflammation and immune diseases, including inflammatory skin diseases. Therefore, understanding the biological and immunological characteristics of MSCs is important to standardize and optimize MSC-based regenerative therapy. In this review, we highlight the mechanisms underlying MSC-mediated immunomodulation and tissue repair/regeneration and present the latest development of MSC-based clinical trials on cutaneous diseases.http://dx.doi.org/10.1155/2021/8834590
collection DOAJ
language English
format Article
sources DOAJ
author Yanyun Li
Ziyu Ye
Weiqin Yang
Qunzhou Zhang
Jincheng Zeng
spellingShingle Yanyun Li
Ziyu Ye
Weiqin Yang
Qunzhou Zhang
Jincheng Zeng
An Update on the Potential of Mesenchymal Stem Cell Therapy for Cutaneous Diseases
Stem Cells International
author_facet Yanyun Li
Ziyu Ye
Weiqin Yang
Qunzhou Zhang
Jincheng Zeng
author_sort Yanyun Li
title An Update on the Potential of Mesenchymal Stem Cell Therapy for Cutaneous Diseases
title_short An Update on the Potential of Mesenchymal Stem Cell Therapy for Cutaneous Diseases
title_full An Update on the Potential of Mesenchymal Stem Cell Therapy for Cutaneous Diseases
title_fullStr An Update on the Potential of Mesenchymal Stem Cell Therapy for Cutaneous Diseases
title_full_unstemmed An Update on the Potential of Mesenchymal Stem Cell Therapy for Cutaneous Diseases
title_sort update on the potential of mesenchymal stem cell therapy for cutaneous diseases
publisher Hindawi Limited
series Stem Cells International
issn 1687-966X
1687-9678
publishDate 2021-01-01
description Mesenchymal stem or stromal cells (MSCs) are nonhematopoietic postnatal stem cells with self-renewal, multipotent differentiation, and potent immunomodulatory and anti-inflammatory capabilities, thus playing an important role in tissue repair and regeneration. Numerous clinical and preclinical studies have demonstrated the potential application of MSCs in the treatment of tissue inflammation and immune diseases, including inflammatory skin diseases. Therefore, understanding the biological and immunological characteristics of MSCs is important to standardize and optimize MSC-based regenerative therapy. In this review, we highlight the mechanisms underlying MSC-mediated immunomodulation and tissue repair/regeneration and present the latest development of MSC-based clinical trials on cutaneous diseases.
url http://dx.doi.org/10.1155/2021/8834590
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