HI A ASSOCIATION WITH CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA

• Main Authors: BATOOL M. MAHDI, salalwa M. Shareef
• Format: Article
• Language: English
• Published: Faculty of Medicine University of Baghdad 2005-07-01
• Series: مجلة كلية الطب
• Subjects: ALL, HLA typing, antibodies, blood group.
• Online Access: http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1647

Summary: OBJECTIVE Many associations have been found between specific HLA antigens and increased susceptibility to various diseases . So we tried to associate class I and class II antigens with acute lymphoblastic leukemia . We also demonstrate the presence of antibodies in serum of acute lymphoblastic leukemic patients against HLA class I. DESIGN: Prospective study. SETTING: Tissue typing and histocompatibility center at Al- Karamah Teaching Hospital. PATIENTS AND METHOD: 70 acute lymphoblastic leukemia patients from pediatric hospitals. HLA ( human leukocyte antigens) typing done for them by serological method and cross matching and blood grouping were also done for them. RESULTS: there was significant difference between patients and control groups regarding HLA -C6.DR1, DR4, DR7, DQ1.DQ2 ,DQ3, DQ4. There was 14.2 % (10/70) of patients had antibodies against HLA class I. There was no significant association between blood group and acute lymphoblastic leukemia . CONCLUSION: Genetic factor increased susceptibility with acute lymphoblastic leukemia ( HLA- DR1 DQ1, HLA - DR4 DQ4, HLA- DR4 DQ3, HLA- DR7 DQ2. This HLA typing increased susceptibility to be affected with leukemia after infection. RECOMMEND A TION: HLA typing was done to acute lymphoblastic leukemic patients by molecular -DNA based method (PCR-SSP, RSCA) in addition to serological method.