miR-148a Promoted Cell Proliferation by Targeting p27 in Gastric Cancer Cells
<p>Accumulating evidence has shown that miRNAs are aberrantly expressed in human gastric cancer and crucial to tumorigenesis. Herein, we identified the role of miR-148a in gastric cell proliferation. miR-148a knockdown inhibited cell proliferation in gastric cancer cell lines. Conversely, miR-...
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doaj-de20b99b4f96467ca8b56dc37aeae3ac2020-11-24T21:04:38ZengIvyspring International PublisherInternational Journal of Biological Sciences1449-22882011-01-0175567574miR-148a Promoted Cell Proliferation by Targeting p27 in Gastric Cancer CellsShui-Long Guo, Zheng Peng, Xue Yang, Kai-Ji Fan, Hui Ye, Zhen-Hua Li, Yan Wang, Xiao-Li Xu, Jun Li, You-Liang Wang, Yan Teng, Xiao Yang<p>Accumulating evidence has shown that miRNAs are aberrantly expressed in human gastric cancer and crucial to tumorigenesis. Herein, we identified the role of miR-148a in gastric cell proliferation. miR-148a knockdown inhibited cell proliferation in gastric cancer cell lines. Conversely, miR-148a overexpression promoted cell proliferation and cell cycle progression. p27, a key inhibitor of cell cycle, was verified as the target of miR-148a, indicating miR-148a might downregulate p27 expression to promote gastric cell proliferation. Moreover, we confirmed that miR-148a expression was frequently and dramatically downregulated in human advanced gastric cancer tissues, and observed a good inverse correlation between miR-148a and p27 expression in tumor samples. Thus, our results demonstrated that miR-148a downregulation might exert some sort of antagonistic function in cell proliferation, rather than promote cell proliferation in gastric cancer.</p>http://www.biolsci.org/v07p0567.htm |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shui-Long Guo, Zheng Peng, Xue Yang, Kai-Ji Fan, Hui Ye, Zhen-Hua Li, Yan Wang, Xiao-Li Xu, Jun Li, You-Liang Wang, Yan Teng, Xiao Yang |
spellingShingle |
Shui-Long Guo, Zheng Peng, Xue Yang, Kai-Ji Fan, Hui Ye, Zhen-Hua Li, Yan Wang, Xiao-Li Xu, Jun Li, You-Liang Wang, Yan Teng, Xiao Yang miR-148a Promoted Cell Proliferation by Targeting p27 in Gastric Cancer Cells International Journal of Biological Sciences |
author_facet |
Shui-Long Guo, Zheng Peng, Xue Yang, Kai-Ji Fan, Hui Ye, Zhen-Hua Li, Yan Wang, Xiao-Li Xu, Jun Li, You-Liang Wang, Yan Teng, Xiao Yang |
author_sort |
Shui-Long Guo, Zheng Peng, Xue Yang, Kai-Ji Fan, Hui Ye, Zhen-Hua Li, Yan Wang, Xiao-Li Xu, Jun Li, You-Liang Wang, Yan Teng, Xiao Yang |
title |
miR-148a Promoted Cell Proliferation by Targeting p27 in Gastric Cancer Cells |
title_short |
miR-148a Promoted Cell Proliferation by Targeting p27 in Gastric Cancer Cells |
title_full |
miR-148a Promoted Cell Proliferation by Targeting p27 in Gastric Cancer Cells |
title_fullStr |
miR-148a Promoted Cell Proliferation by Targeting p27 in Gastric Cancer Cells |
title_full_unstemmed |
miR-148a Promoted Cell Proliferation by Targeting p27 in Gastric Cancer Cells |
title_sort |
mir-148a promoted cell proliferation by targeting p27 in gastric cancer cells |
publisher |
Ivyspring International Publisher |
series |
International Journal of Biological Sciences |
issn |
1449-2288 |
publishDate |
2011-01-01 |
description |
<p>Accumulating evidence has shown that miRNAs are aberrantly expressed in human gastric cancer and crucial to tumorigenesis. Herein, we identified the role of miR-148a in gastric cell proliferation. miR-148a knockdown inhibited cell proliferation in gastric cancer cell lines. Conversely, miR-148a overexpression promoted cell proliferation and cell cycle progression. p27, a key inhibitor of cell cycle, was verified as the target of miR-148a, indicating miR-148a might downregulate p27 expression to promote gastric cell proliferation. Moreover, we confirmed that miR-148a expression was frequently and dramatically downregulated in human advanced gastric cancer tissues, and observed a good inverse correlation between miR-148a and p27 expression in tumor samples. Thus, our results demonstrated that miR-148a downregulation might exert some sort of antagonistic function in cell proliferation, rather than promote cell proliferation in gastric cancer.</p> |
url |
http://www.biolsci.org/v07p0567.htm |
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