Generation of recombinant baculovirus expressing atoxic C-terminal CPA toxin of Clostridium perfringens and production of specific antibodies

Generation of recombinant baculovirus expressing atoxic C-terminal CPA toxin of Clostridium perfringens and production of specific antibodies

Abstract Background Clostridium perfringens is the causative agent of several diseases and enteric infections in animals and humans. The virulence of C. perfringens is largely attributable to the production of numerous toxins; of these, the alpha toxin (CPA) plays a crucial role in histotoxic infect...

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Bibliographic Details
Main Authors: Katia Forti, Monica Cagiola, Martina Pellegrini, Lucia Anzalone, Antonella Di Paolo, Sara Corneli, Giulio Severi, Antonio De Giuseppe
Format: Article
Language:English
Published: BMC 2020-01-01
Series:BMC Biotechnology
Subjects:
Clostridium perfringens
L21 leader sequence
Atoxic rBacCPA250–363H6
Affinity chromatography
Recombinant vaccines
Online Access:https://doi.org/10.1186/s12896-019-0597-4

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