The Impact of the Expression Level of Intratumoral Dihydropyrimidine Dehydrogenase on Chemotherapy Sensitivity and Survival of Patients in Gastric Cancer: A Meta-Analysis
The potential impact that the intratumoral expression level of dihydropyrimidine dehydrogenase (DPD) has on chemotherapy sensitivity and long-term survival for gastric cancer (GC) patients remains controversial; therefore, this study seeks to clarify this issue. Our meta-analysis was performed using...
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Online Access: | http://dx.doi.org/10.1155/2017/9202676 |
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doaj-de2fc3e5d19e4fcab7702606d10e664b2020-11-24T22:56:21ZengHindawi LimitedDisease Markers0278-02401875-86302017-01-01201710.1155/2017/92026769202676The Impact of the Expression Level of Intratumoral Dihydropyrimidine Dehydrogenase on Chemotherapy Sensitivity and Survival of Patients in Gastric Cancer: A Meta-AnalysisCong Zhang0Hongpeng Liu1Bin Ma2Yongxi Song3Peng Gao4Yingying Xu5Dehao Yu6Zhenning Wang7Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Breast Surgery, The First Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Shenyang 110001, ChinaThe potential impact that the intratumoral expression level of dihydropyrimidine dehydrogenase (DPD) has on chemotherapy sensitivity and long-term survival for gastric cancer (GC) patients remains controversial; therefore, this study seeks to clarify this issue. Our meta-analysis was performed using Review Manager (RevMan) 5.3 software. In vitro drug sensitivity tests, correlation coefficients between sensitivity to 5-fluorouracil (5-FU), and expression levels of intratumoral DPD were used as effective indexes to analyse. Overall survival (OS) and progression-free survival (PFS) were used as endpoints for patient outcome, and hazard ratios (HRs) and 95% confidence intervals (CIs) were noted as measures of effect. There were 15 eligible studies including 1805 patients for the final analysis. The analysis revealed a statistically significant difference between the expression level of intratumoral DPD activity, DPD mRNA levels, and sensitivity to 5-FU in GC patients, with high expression levels of intratumoral DPD resulting in low sensitivity to 5-FU. However, no matter what therapeutic regimens were used, there was no significant difference for patient outcomes between high and low DPD expression groups, either in OS or in PFS. In conclusion, high levels of intratumoral DPD expression have a negative impact on sensitivity to 5-FU in GC patients, but no prognostic value for long-term survival was uncovered.http://dx.doi.org/10.1155/2017/9202676 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cong Zhang Hongpeng Liu Bin Ma Yongxi Song Peng Gao Yingying Xu Dehao Yu Zhenning Wang |
spellingShingle |
Cong Zhang Hongpeng Liu Bin Ma Yongxi Song Peng Gao Yingying Xu Dehao Yu Zhenning Wang The Impact of the Expression Level of Intratumoral Dihydropyrimidine Dehydrogenase on Chemotherapy Sensitivity and Survival of Patients in Gastric Cancer: A Meta-Analysis Disease Markers |
author_facet |
Cong Zhang Hongpeng Liu Bin Ma Yongxi Song Peng Gao Yingying Xu Dehao Yu Zhenning Wang |
author_sort |
Cong Zhang |
title |
The Impact of the Expression Level of Intratumoral Dihydropyrimidine Dehydrogenase on Chemotherapy Sensitivity and Survival of Patients in Gastric Cancer: A Meta-Analysis |
title_short |
The Impact of the Expression Level of Intratumoral Dihydropyrimidine Dehydrogenase on Chemotherapy Sensitivity and Survival of Patients in Gastric Cancer: A Meta-Analysis |
title_full |
The Impact of the Expression Level of Intratumoral Dihydropyrimidine Dehydrogenase on Chemotherapy Sensitivity and Survival of Patients in Gastric Cancer: A Meta-Analysis |
title_fullStr |
The Impact of the Expression Level of Intratumoral Dihydropyrimidine Dehydrogenase on Chemotherapy Sensitivity and Survival of Patients in Gastric Cancer: A Meta-Analysis |
title_full_unstemmed |
The Impact of the Expression Level of Intratumoral Dihydropyrimidine Dehydrogenase on Chemotherapy Sensitivity and Survival of Patients in Gastric Cancer: A Meta-Analysis |
title_sort |
impact of the expression level of intratumoral dihydropyrimidine dehydrogenase on chemotherapy sensitivity and survival of patients in gastric cancer: a meta-analysis |
publisher |
Hindawi Limited |
series |
Disease Markers |
issn |
0278-0240 1875-8630 |
publishDate |
2017-01-01 |
description |
The potential impact that the intratumoral expression level of dihydropyrimidine dehydrogenase (DPD) has on chemotherapy sensitivity and long-term survival for gastric cancer (GC) patients remains controversial; therefore, this study seeks to clarify this issue. Our meta-analysis was performed using Review Manager (RevMan) 5.3 software. In vitro drug sensitivity tests, correlation coefficients between sensitivity to 5-fluorouracil (5-FU), and expression levels of intratumoral DPD were used as effective indexes to analyse. Overall survival (OS) and progression-free survival (PFS) were used as endpoints for patient outcome, and hazard ratios (HRs) and 95% confidence intervals (CIs) were noted as measures of effect. There were 15 eligible studies including 1805 patients for the final analysis. The analysis revealed a statistically significant difference between the expression level of intratumoral DPD activity, DPD mRNA levels, and sensitivity to 5-FU in GC patients, with high expression levels of intratumoral DPD resulting in low sensitivity to 5-FU. However, no matter what therapeutic regimens were used, there was no significant difference for patient outcomes between high and low DPD expression groups, either in OS or in PFS. In conclusion, high levels of intratumoral DPD expression have a negative impact on sensitivity to 5-FU in GC patients, but no prognostic value for long-term survival was uncovered. |
url |
http://dx.doi.org/10.1155/2017/9202676 |
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