C9orf72 arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import

C9orf72 arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import

Disruption of nucleocytoplasmic transport is increasingly implicated in the pathogenesis of neurodegenerative diseases, including ALS caused by a C9orf72 hexanucleotide repeat expansion. However, the mechanism(s) remain unclear. Karyopherins, including importin β and its cargo adaptors, have been sh...

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Bibliographic Details
Main Authors: Lindsey R Hayes, Lauren Duan, Kelly Bowen, Petr Kalab, Jeffrey D Rothstein
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-03-01
Series:eLife
Subjects:
nucleocytoplasmic transport
amyotrophic lateral sclerosis
importin beta
dipeptide repeat proteins
karyopherins
C9orf72
Online Access:https://elifesciences.org/articles/51685

Internet

https://elifesciences.org/articles/51685

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