Efficient Capsid Antigen Presentation From Adeno-Associated Virus Empty Virions In Vivo

Efficient Capsid Antigen Presentation From Adeno-Associated Virus Empty Virions In Vivo

Adeno-associated virus (AAV) vectors have been successfully applied in clinical trials for hemophilic patients. Although promising, the clinical results suggest that the capsid-specific CD8+T cell response has a negative effect on therapeutic success. In an in vitro analysis using an engineered AAV...

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Bibliographic Details
Main Authors: Xiaolei Pei, Lauriel Freya Earley, Yi He, Xiaojing Chen, Nikita Elexa Hall, Richard Jude Samulski, Chengwen Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
adeno-associated virus
capsid
antigen presentation
CD8+ T cells
empty virions
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00844/full

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