Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a
Uhrf1 is a known regulator of heterochromatin and DNA methylation in embryonic stem cells (ESCs). Here, the authors demonstrate that Uhrf1 acts together with the Set1/COMPASS complex regulator of active transcription to promote H3K4 methylation at bivalent loci and Uhrf1 loss results in disruption o...
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Bibliographic Details
Main Authors: |
Kun-Yong Kim,
Yoshiaki Tanaka,
Juan Su,
Bilal Cakir,
Yangfei Xiang,
Benjamin Patterson,
Junjun Ding,
Yong-Wook Jung,
Ji-Hyun Kim,
Eriona Hysolli,
Haelim Lee,
Rana Dajani,
Jonghwan Kim,
Mei Zhong,
Jeong-Heon Lee,
David Skalnik,
Jeong Mook Lim,
Gareth J. Sullivan,
Jianlong Wang,
In-Hyun Park |
Format: | Article
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Language: | English |
Published: |
Nature Publishing Group
2018-07-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-018-04818-0
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