Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a

Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a

Uhrf1 is a known regulator of heterochromatin and DNA methylation in embryonic stem cells (ESCs). Here, the authors demonstrate that Uhrf1 acts together with the Set1/COMPASS complex regulator of active transcription to promote H3K4 methylation at bivalent loci and Uhrf1 loss results in disruption o...

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Main Authors: Kun-Yong Kim, Yoshiaki Tanaka, Juan Su, Bilal Cakir, Yangfei Xiang, Benjamin Patterson, Junjun Ding, Yong-Wook Jung, Ji-Hyun Kim, Eriona Hysolli, Haelim Lee, Rana Dajani, Jonghwan Kim, Mei Zhong, Jeong-Heon Lee, David Skalnik, Jeong Mook Lim, Gareth J. Sullivan, Jianlong Wang, In-Hyun Park
Format: Article
Language:English
Published: Nature Publishing Group 2018-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04818-0
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spelling doaj-de5d0fb025b047ba960f4909f28229052021-05-11T10:25:46ZengNature Publishing GroupNature Communications2041-17232018-07-019111310.1038/s41467-018-04818-0Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1aKun-Yong Kim0Yoshiaki Tanaka1Juan Su2Bilal Cakir3Yangfei Xiang4Benjamin Patterson5Junjun Ding6Yong-Wook Jung7Ji-Hyun Kim8Eriona Hysolli9Haelim Lee10Rana Dajani11Jonghwan Kim12Mei Zhong13Jeong-Heon Lee14David Skalnik15Jeong Mook Lim16Gareth J. Sullivan17Jianlong Wang18In-Hyun Park19Department of Genetics, Yale Stem Cell Center, Yale Child Study Center, Yale School of MedicineDepartment of Genetics, Yale Stem Cell Center, Yale Child Study Center, Yale School of MedicineDepartment of Genetics, Yale Stem Cell Center, Yale Child Study Center, Yale School of MedicineDepartment of Genetics, Yale Stem Cell Center, Yale Child Study Center, Yale School of MedicineDepartment of Genetics, Yale Stem Cell Center, Yale Child Study Center, Yale School of MedicineDepartment of Genetics, Yale Stem Cell Center, Yale Child Study Center, Yale School of MedicineDepartment of Cell, Developmental and Regenerative Biology, Black Family Stem Cell Institute, Icahn School of Medicine at Mount SinaiDepartment of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA UniversityDepartment of Genetics, Yale Stem Cell Center, Yale Child Study Center, Yale School of MedicineDepartment of Genetics, Yale Stem Cell Center, Yale Child Study Center, Yale School of MedicineDepartment of Genetics, Yale Stem Cell Center, Yale Child Study Center, Yale School of MedicineDepartment of Biology and Biotechnology, Hashemite UniversityDepartment of Molecular Biosciences, Institute for Cellular and Molecular Biology, Center for Systems and Synthetic Biology, the University of Texas at AustinDepartment of Cell Biology, Yale Stem Cell Center, Yale School of MedicineDepartment of Biology, School of Science, Indiana University-Purdue University IndianapolisDepartment of Biology, School of Science, Indiana University-Purdue University IndianapolisDepartment of Agricultural Biotechnology, Seoul National UniversityDepartment of Molecular Medicine, Hybrid Technology Hub - Centre of Excellence, Institute of Basic Medical Sciences, University of OsloDepartment of Cell, Developmental and Regenerative Biology, Black Family Stem Cell Institute, Icahn School of Medicine at Mount SinaiDepartment of Genetics, Yale Stem Cell Center, Yale Child Study Center, Yale School of MedicineUhrf1 is a known regulator of heterochromatin and DNA methylation in embryonic stem cells (ESCs). Here, the authors demonstrate that Uhrf1 acts together with the Set1/COMPASS complex regulator of active transcription to promote H3K4 methylation at bivalent loci and Uhrf1 loss results in disruption of differentiation.https://doi.org/10.1038/s41467-018-04818-0
collection DOAJ
language English
format Article
sources DOAJ
author Kun-Yong Kim
Yoshiaki Tanaka
Juan Su
Bilal Cakir
Yangfei Xiang
Benjamin Patterson
Junjun Ding
Yong-Wook Jung
Ji-Hyun Kim
Eriona Hysolli
Haelim Lee
Rana Dajani
Jonghwan Kim
Mei Zhong
Jeong-Heon Lee
David Skalnik
Jeong Mook Lim
Gareth J. Sullivan
Jianlong Wang
In-Hyun Park
spellingShingle Kun-Yong Kim
Yoshiaki Tanaka
Juan Su
Bilal Cakir
Yangfei Xiang
Benjamin Patterson
Junjun Ding
Yong-Wook Jung
Ji-Hyun Kim
Eriona Hysolli
Haelim Lee
Rana Dajani
Jonghwan Kim
Mei Zhong
Jeong-Heon Lee
David Skalnik
Jeong Mook Lim
Gareth J. Sullivan
Jianlong Wang
In-Hyun Park
Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a
Nature Communications
author_facet Kun-Yong Kim
Yoshiaki Tanaka
Juan Su
Bilal Cakir
Yangfei Xiang
Benjamin Patterson
Junjun Ding
Yong-Wook Jung
Ji-Hyun Kim
Eriona Hysolli
Haelim Lee
Rana Dajani
Jonghwan Kim
Mei Zhong
Jeong-Heon Lee
David Skalnik
Jeong Mook Lim
Gareth J. Sullivan
Jianlong Wang
In-Hyun Park
author_sort Kun-Yong Kim
title Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a
title_short Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a
title_full Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a
title_fullStr Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a
title_full_unstemmed Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a
title_sort uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through setd1a
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-07-01
description Uhrf1 is a known regulator of heterochromatin and DNA methylation in embryonic stem cells (ESCs). Here, the authors demonstrate that Uhrf1 acts together with the Set1/COMPASS complex regulator of active transcription to promote H3K4 methylation at bivalent loci and Uhrf1 loss results in disruption of differentiation.
url https://doi.org/10.1038/s41467-018-04818-0
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