Impact of Advanced Age on the Clinical Presentation and Outcome of Sporadic Medullary Thyroid Carcinoma

• Main Authors: Antonio Matrone, Carla Gambale, Alessandro Prete, Paolo Piaggi, Virginia Cappagli, Valeria Bottici, Cristina Romei, Raffaele Ciampi, Liborio Torregrossa, Luigi De Napoli, Eleonora Molinaro, Gabriele Materazzi, Fulvio Basolo, Rossella Elisei
• Format: Article
• Language: English
• Published: MDPI AG 2021-12-01
• Series: Cancers
• Subjects: medullary thyroid carcinoma; sporadic; age; distant metastasis; death rate
• Online Access: https://www.mdpi.com/2072-6694/13/1/94

Sporadic medullary thyroid carcinoma (MTC) is a rare malignancy with a heterogeneous clinical course. Several potential prognostic factors have been investigated, but the impact of some of these is controversial, such as age at diagnosis. We evaluated the data of 432 sporadic MTC patients followed-up for a median of 7.4 years. Patients were divided and compared according to their age at diagnosis in group A (<65 years—n = 338, 78.2%) and group B (≥65 years—n = 94, 21.8%). No differences were detected between the two groups. Median follow-up time was significantly longer in patients <65 than ≥65 years. We observed 41 (9.5%) cancer-related death events. The death rate was similar between the two age groups. However, the Kaplan Meier curve showed a longer survival time for younger patients compared to older patients [HR 2.5 (CI 95%: 1.27–4.94), <i>p</i> < 0.01]. Nevertheless, no differences in the aggressiveness of the disease at presentation and in the number and type of treatments performed were found in the two subgroups of dead patients. In patients with sporadic MTC, age at diagnosis did not correlate with any clinical and pathological features. Cancer-related death events are similar in older and younger patients, but survival time is longer in the younger.