| Summary: | Background
Current smoking is associated with type 2 diabetes mellitus and impaired glucose tolerance but its
association with the metabolic syndrome (metS), particularly with sufficiently sampled African American
representation, has not been clearly established.
Objective
To assess whether a) metS is associated with smoking; b) any increased risk of metS among smokers is
independent of body mass index (BMI) compared with non-smokers; c) smoking status is differentially associated
with the metS and its components across different ethnic groups.
Methods
Cross sectional analysis of the Multi-Ethnic Study of Atherosclerosis (MESA) a community populationbased
sample free of cardiovascular disease.
Results
Current smokers (N = 769) had higher risk of metS (odds ratio [OR, 95% confidence interval]: 1.4, 1.1-1.7)
versus never (reference, N = 2981) and former smokers (1.0, 0.8-1.1, N = 2163) and for metS components: high waist
circumference (WC) (OR:1.9, 1.2-2.1), low high density lipoprotein cholesterol (HDL-C) (1.5, 1.3-1.8), elevated plasma
triglycerides (TG) (OR:1.4, 1.2-1.7) as well as high C-reactive protein (CRP, an inflammatory marker) concentration
(OR: 1.6,1.3-2.0) compared to never and former smokers after adjustment for BMI. A smoking status by ethnicity
interaction occurred such that African American current and former smokers had greater likelihood of low HDL-C
than White counterparts.
Conclusions
This study found that smoking is associated with the metS and despite the lower BMI of current
smokers the prevalence of low HDL-C, elevated TG and CRP is higher among them than among non-smokers.
African Americans generally have higher HDL-C than Whites but smoking wipes out this advantage.
Multi-Ethnic Study of Atherosclerosis (MESA) ClinicalTrials.gov Identifier: NCT00005487
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