The urologic epithelial stem cell database (UESC) – a web tool for cell type-specific gene expression and immunohistochemistry images of the prostate and bladder
<p>Abstract</p> <p>Background</p> <p>Public databases are crucial for analysis of high-dimensional gene and protein expression data. The Urologic Epithelial Stem Cells (UESC) database <url>http://scgap.systemsbiology.net/</url> is a public database that cont...
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doaj-de68f5fc3f9f4d44b7c7ee7e71477f122020-11-24T21:10:30ZengBMCBMC Urology1471-24902007-12-01711910.1186/1471-2490-7-19The urologic epithelial stem cell database (UESC) – a web tool for cell type-specific gene expression and immunohistochemistry images of the prostate and bladderKorb MartinCampbell David SDeutsch Eric WPascal Laura ETrue Lawrence DLiu Alvin Y<p>Abstract</p> <p>Background</p> <p>Public databases are crucial for analysis of high-dimensional gene and protein expression data. The Urologic Epithelial Stem Cells (UESC) database <url>http://scgap.systemsbiology.net/</url> is a public database that contains gene and protein information for the major cell types of the prostate, prostate cancer cell lines, and a cancer cell type isolated from a primary tumor. Similarly, such information is available for urinary bladder cell types.</p> <p>Description</p> <p>Two major data types were archived in the database, protein abundance localization data from immunohistochemistry images, and transcript abundance data principally from DNA microarray analysis. Data results were organized in modules that were made to operate independently but built upon a core functionality. Gene array data and immunostaining images for human and mouse prostate and bladder were made available for interrogation. Data analysis capabilities include: (1) CD (cluster designation) cell surface protein data. For each cluster designation molecule, a data summary allows easy retrieval of images (at multiple magnifications). (2) Microarray data. Single gene or batch search can be initiated with Affymetrix Probeset ID, Gene Name, or Accession Number together with options of coalescing probesets and/or replicates.</p> <p>Conclusion</p> <p>Databases are invaluable for biomedical research, and their utility depends on data quality and user friendliness. UESC provides for database queries and tools to examine cell type-specific gene expression (normal vs. cancer), whereas most other databases contain only whole tissue expression datasets. The UESC database provides a valuable tool in the analysis of differential gene expression in prostate cancer genes in cancer progression.</p> http://www.biomedcentral.com/1471-2490/7/19 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Korb Martin Campbell David S Deutsch Eric W Pascal Laura E True Lawrence D Liu Alvin Y |
spellingShingle |
Korb Martin Campbell David S Deutsch Eric W Pascal Laura E True Lawrence D Liu Alvin Y The urologic epithelial stem cell database (UESC) – a web tool for cell type-specific gene expression and immunohistochemistry images of the prostate and bladder BMC Urology |
author_facet |
Korb Martin Campbell David S Deutsch Eric W Pascal Laura E True Lawrence D Liu Alvin Y |
author_sort |
Korb Martin |
title |
The urologic epithelial stem cell database (UESC) – a web tool for cell type-specific gene expression and immunohistochemistry images of the prostate and bladder |
title_short |
The urologic epithelial stem cell database (UESC) – a web tool for cell type-specific gene expression and immunohistochemistry images of the prostate and bladder |
title_full |
The urologic epithelial stem cell database (UESC) – a web tool for cell type-specific gene expression and immunohistochemistry images of the prostate and bladder |
title_fullStr |
The urologic epithelial stem cell database (UESC) – a web tool for cell type-specific gene expression and immunohistochemistry images of the prostate and bladder |
title_full_unstemmed |
The urologic epithelial stem cell database (UESC) – a web tool for cell type-specific gene expression and immunohistochemistry images of the prostate and bladder |
title_sort |
urologic epithelial stem cell database (uesc) – a web tool for cell type-specific gene expression and immunohistochemistry images of the prostate and bladder |
publisher |
BMC |
series |
BMC Urology |
issn |
1471-2490 |
publishDate |
2007-12-01 |
description |
<p>Abstract</p> <p>Background</p> <p>Public databases are crucial for analysis of high-dimensional gene and protein expression data. The Urologic Epithelial Stem Cells (UESC) database <url>http://scgap.systemsbiology.net/</url> is a public database that contains gene and protein information for the major cell types of the prostate, prostate cancer cell lines, and a cancer cell type isolated from a primary tumor. Similarly, such information is available for urinary bladder cell types.</p> <p>Description</p> <p>Two major data types were archived in the database, protein abundance localization data from immunohistochemistry images, and transcript abundance data principally from DNA microarray analysis. Data results were organized in modules that were made to operate independently but built upon a core functionality. Gene array data and immunostaining images for human and mouse prostate and bladder were made available for interrogation. Data analysis capabilities include: (1) CD (cluster designation) cell surface protein data. For each cluster designation molecule, a data summary allows easy retrieval of images (at multiple magnifications). (2) Microarray data. Single gene or batch search can be initiated with Affymetrix Probeset ID, Gene Name, or Accession Number together with options of coalescing probesets and/or replicates.</p> <p>Conclusion</p> <p>Databases are invaluable for biomedical research, and their utility depends on data quality and user friendliness. UESC provides for database queries and tools to examine cell type-specific gene expression (normal vs. cancer), whereas most other databases contain only whole tissue expression datasets. The UESC database provides a valuable tool in the analysis of differential gene expression in prostate cancer genes in cancer progression.</p> |
url |
http://www.biomedcentral.com/1471-2490/7/19 |
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