Genetic heterogeneity of dolphin morbilliviruses detected in the Spanish Mediterranean in inter-epizootic period
Abstract Background In the last 20 years, Cetacean Morbillivirus (CeMV) has been responsible for many die-offs in marine mammals worldwide, as clearly exemplified by the three dolphin morbillivirus (DMV) epizootics of 1990–1992, 2006–2008 and 2011 that affected Mediterranean striped dolphins (Stenel...
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doaj-de737ec12b804031958af736e1b63a322020-11-24T21:46:36ZengBMCBMC Veterinary Research1746-61482018-08-0114111010.1186/s12917-018-1559-0Genetic heterogeneity of dolphin morbilliviruses detected in the Spanish Mediterranean in inter-epizootic periodConsuelo Rubio-Guerri0M. Ángeles Jiménez1Mar Melero2Josué Díaz-Delgado3Eva Sierra4Manuel Arbelo5Edwige N. Bellière6Jose L. Crespo-Picazo7Daniel García-Párraga8Fernando Esperón9Jose M. Sánchez-Vizcaíno10VISAVET Center and Animal Health Department, Veterinary School, Complutense University of MadridMedicine and Surgery Department (Anatomic Pathology), Veterinary School, Complutense University of MadridVISAVET Center and Animal Health Department, Veterinary School, Complutense University of MadridUnit of Histology and Veterinary Pathology, Institute for Animal Health, Veterinary School, University of Las Palmas de Gran CanariaUnit of Histology and Veterinary Pathology, Institute for Animal Health, Veterinary School, University of Las Palmas de Gran CanariaUnit of Histology and Veterinary Pathology, Institute for Animal Health, Veterinary School, University of Las Palmas de Gran CanariaNational Institute for Agricultural and Food Research and TechnologyFundación Oceanografic de la Comunitat ValencianaFundación Oceanografic de la Comunitat ValencianaNational Institute for Agricultural and Food Research and TechnologyVISAVET Center and Animal Health Department, Veterinary School, Complutense University of MadridAbstract Background In the last 20 years, Cetacean Morbillivirus (CeMV) has been responsible for many die-offs in marine mammals worldwide, as clearly exemplified by the three dolphin morbillivirus (DMV) epizootics of 1990–1992, 2006–2008 and 2011 that affected Mediterranean striped dolphins (Stenella coeruleoalba). Systemic infection caused by DMV in the Mediterranean has been reported only during these outbreaks. Results We report the infection of five striped dolphins (Stenella coeruleoalba) stranded on the Spanish Mediterranean coast of Valencia after the last DMV outbreak that ended in 2011. Animal 1 stranded in late 2011 and Animal 2 in 2012. Systemic infection affecting all tissues was found based on histopathology and positive immunohistochemical and polymerase chain reaction positive results. Animal 3 stranded in 2014; molecular and immunohistochemical detection was positive only in the central nervous system. Animals 4 and 5 stranded in 2015, and DMV antigen was found in several tissues. Partial sequences of the DMV phosphoprotein (P), nucleoprotein (N), and hemagglutinin (H) genes were identical for Animals 2, 3, 4, and 5, and were remarkably different from those in Animal 1. The P sequence from Animal 1 was identical to that of the DMV strain that caused the epizootic of 2011 in the Spanish Mediterranean. The corresponding sequence from Animals 2–5 was identical to that from a striped dolphin stranded in 2011 on the Canary Islands and to six dolphins stranded in northeastern Atlantic of the Iberian Peninsula. Conclusions These results suggest the existence of an endemic infection cycle among striped dolphins in the Mediterranean that may lead to occasional systemic disease presentations outside epizootic periods. This cycle involves multiple pathogenic viral strains, one of which may have originated in the Atlantic Ocean.http://link.springer.com/article/10.1186/s12917-018-1559-0ParamyxoviridaeEndemic ocurrenceDolphin morbillivirusStenella coeruleoalbaMediterranean striped dolphin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Consuelo Rubio-Guerri M. Ángeles Jiménez Mar Melero Josué Díaz-Delgado Eva Sierra Manuel Arbelo Edwige N. Bellière Jose L. Crespo-Picazo Daniel García-Párraga Fernando Esperón Jose M. Sánchez-Vizcaíno |
spellingShingle |
Consuelo Rubio-Guerri M. Ángeles Jiménez Mar Melero Josué Díaz-Delgado Eva Sierra Manuel Arbelo Edwige N. Bellière Jose L. Crespo-Picazo Daniel García-Párraga Fernando Esperón Jose M. Sánchez-Vizcaíno Genetic heterogeneity of dolphin morbilliviruses detected in the Spanish Mediterranean in inter-epizootic period BMC Veterinary Research Paramyxoviridae Endemic ocurrence Dolphin morbillivirus Stenella coeruleoalba Mediterranean striped dolphin |
author_facet |
Consuelo Rubio-Guerri M. Ángeles Jiménez Mar Melero Josué Díaz-Delgado Eva Sierra Manuel Arbelo Edwige N. Bellière Jose L. Crespo-Picazo Daniel García-Párraga Fernando Esperón Jose M. Sánchez-Vizcaíno |
author_sort |
Consuelo Rubio-Guerri |
title |
Genetic heterogeneity of dolphin morbilliviruses detected in the Spanish Mediterranean in inter-epizootic period |
title_short |
Genetic heterogeneity of dolphin morbilliviruses detected in the Spanish Mediterranean in inter-epizootic period |
title_full |
Genetic heterogeneity of dolphin morbilliviruses detected in the Spanish Mediterranean in inter-epizootic period |
title_fullStr |
Genetic heterogeneity of dolphin morbilliviruses detected in the Spanish Mediterranean in inter-epizootic period |
title_full_unstemmed |
Genetic heterogeneity of dolphin morbilliviruses detected in the Spanish Mediterranean in inter-epizootic period |
title_sort |
genetic heterogeneity of dolphin morbilliviruses detected in the spanish mediterranean in inter-epizootic period |
publisher |
BMC |
series |
BMC Veterinary Research |
issn |
1746-6148 |
publishDate |
2018-08-01 |
description |
Abstract Background In the last 20 years, Cetacean Morbillivirus (CeMV) has been responsible for many die-offs in marine mammals worldwide, as clearly exemplified by the three dolphin morbillivirus (DMV) epizootics of 1990–1992, 2006–2008 and 2011 that affected Mediterranean striped dolphins (Stenella coeruleoalba). Systemic infection caused by DMV in the Mediterranean has been reported only during these outbreaks. Results We report the infection of five striped dolphins (Stenella coeruleoalba) stranded on the Spanish Mediterranean coast of Valencia after the last DMV outbreak that ended in 2011. Animal 1 stranded in late 2011 and Animal 2 in 2012. Systemic infection affecting all tissues was found based on histopathology and positive immunohistochemical and polymerase chain reaction positive results. Animal 3 stranded in 2014; molecular and immunohistochemical detection was positive only in the central nervous system. Animals 4 and 5 stranded in 2015, and DMV antigen was found in several tissues. Partial sequences of the DMV phosphoprotein (P), nucleoprotein (N), and hemagglutinin (H) genes were identical for Animals 2, 3, 4, and 5, and were remarkably different from those in Animal 1. The P sequence from Animal 1 was identical to that of the DMV strain that caused the epizootic of 2011 in the Spanish Mediterranean. The corresponding sequence from Animals 2–5 was identical to that from a striped dolphin stranded in 2011 on the Canary Islands and to six dolphins stranded in northeastern Atlantic of the Iberian Peninsula. Conclusions These results suggest the existence of an endemic infection cycle among striped dolphins in the Mediterranean that may lead to occasional systemic disease presentations outside epizootic periods. This cycle involves multiple pathogenic viral strains, one of which may have originated in the Atlantic Ocean. |
topic |
Paramyxoviridae Endemic ocurrence Dolphin morbillivirus Stenella coeruleoalba Mediterranean striped dolphin |
url |
http://link.springer.com/article/10.1186/s12917-018-1559-0 |
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