Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice

Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of a family of proteases that is thought to promote the degradation of the low density lipoprotein receptor (LDLR) through an as yet undefined mechanism. We developed second generation antisense oligonucleotide (ASO) inhibitors target...

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Bibliographic Details
Main Authors: Mark J. Graham, Kristina M. Lemonidis, Charles P. Whipple, Amuthakannan Subramaniam, Brett P. Monia, Stanley T. Crooke, Rosanne M. Crooke
Format: Article
Language:English
Published: Elsevier 2007-04-01
Series:Journal of Lipid Research
Subjects:
antisense oligonucleotides
low density lipoprotein receptor
hyperlipidemia
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520434297

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