Kikuchi-Fujimoto disease in children: two case reports and a review of the literature
Abstract Background Kikuchi-Fujimoto disease is a rare, idiopathic and generally self-limiting cause of lymphadenitis of unknow etiology with a low recurrence rate. The typical clinical signs are cervical lymphadenopathy, fever, and symptoms of respiratory infection, and less frequently chills, nigh...
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doaj-de744e3165cc4c10858939a4cf4922c02020-11-25T02:23:48ZengBMCItalian Journal of Pediatrics1824-72882018-07-014411710.1186/s13052-018-0522-9Kikuchi-Fujimoto disease in children: two case reports and a review of the literatureMara Lelii0Laura Senatore1Ilaria Amodeo2Raffaella Pinzani3Sara Torretta4Stefano Fiori5Paola Marchisio6Samantha Bosis7Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoPediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoNeonatal Intensive Care Unit, Università degli Studi di Milano, Fondazione IRCCS Ca’, Granda Ospedale Maggiore PoliclinicoPediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoDivision of Pathology, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoPediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoPediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoAbstract Background Kikuchi-Fujimoto disease is a rare, idiopathic and generally self-limiting cause of lymphadenitis of unknow etiology with a low recurrence rate. The typical clinical signs are cervical lymphadenopathy, fever, and symptoms of respiratory infection, and less frequently chills, night sweats, arthralgia, rash, and weight loss. Case presentation Here we describe two case reports of Kikuchi Fujimoto disease presenting in Milan within the space of a few months. The first involved the recurrence of KFD in a young boy from Sri Lanka; the second was a rare case of severe KFD complicated by HLH. Conclusions Pediatricians must consider KFD in the differential diagnosis of fever of unknown origin in children, even in western countries. Although rare, recurrence and severe complications are possible. Where symptoms suggest KFD, a systematic diagnostic approach is key. Since no guidelines on the management of KFD are available, further studies should be conducted to investigate the therapeutic options and long term outcome in children.http://link.springer.com/article/10.1186/s13052-018-0522-9Kikuchi-Fujimoto diseaseLymphadenitisRecurrent lymphadenitisPersistent feverRelapsing Kikuchi-Fujimoto diseaseHemophagocytic lymphohistiocytosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mara Lelii Laura Senatore Ilaria Amodeo Raffaella Pinzani Sara Torretta Stefano Fiori Paola Marchisio Samantha Bosis |
spellingShingle |
Mara Lelii Laura Senatore Ilaria Amodeo Raffaella Pinzani Sara Torretta Stefano Fiori Paola Marchisio Samantha Bosis Kikuchi-Fujimoto disease in children: two case reports and a review of the literature Italian Journal of Pediatrics Kikuchi-Fujimoto disease Lymphadenitis Recurrent lymphadenitis Persistent fever Relapsing Kikuchi-Fujimoto disease Hemophagocytic lymphohistiocytosis |
author_facet |
Mara Lelii Laura Senatore Ilaria Amodeo Raffaella Pinzani Sara Torretta Stefano Fiori Paola Marchisio Samantha Bosis |
author_sort |
Mara Lelii |
title |
Kikuchi-Fujimoto disease in children: two case reports and a review of the literature |
title_short |
Kikuchi-Fujimoto disease in children: two case reports and a review of the literature |
title_full |
Kikuchi-Fujimoto disease in children: two case reports and a review of the literature |
title_fullStr |
Kikuchi-Fujimoto disease in children: two case reports and a review of the literature |
title_full_unstemmed |
Kikuchi-Fujimoto disease in children: two case reports and a review of the literature |
title_sort |
kikuchi-fujimoto disease in children: two case reports and a review of the literature |
publisher |
BMC |
series |
Italian Journal of Pediatrics |
issn |
1824-7288 |
publishDate |
2018-07-01 |
description |
Abstract Background Kikuchi-Fujimoto disease is a rare, idiopathic and generally self-limiting cause of lymphadenitis of unknow etiology with a low recurrence rate. The typical clinical signs are cervical lymphadenopathy, fever, and symptoms of respiratory infection, and less frequently chills, night sweats, arthralgia, rash, and weight loss. Case presentation Here we describe two case reports of Kikuchi Fujimoto disease presenting in Milan within the space of a few months. The first involved the recurrence of KFD in a young boy from Sri Lanka; the second was a rare case of severe KFD complicated by HLH. Conclusions Pediatricians must consider KFD in the differential diagnosis of fever of unknown origin in children, even in western countries. Although rare, recurrence and severe complications are possible. Where symptoms suggest KFD, a systematic diagnostic approach is key. Since no guidelines on the management of KFD are available, further studies should be conducted to investigate the therapeutic options and long term outcome in children. |
topic |
Kikuchi-Fujimoto disease Lymphadenitis Recurrent lymphadenitis Persistent fever Relapsing Kikuchi-Fujimoto disease Hemophagocytic lymphohistiocytosis |
url |
http://link.springer.com/article/10.1186/s13052-018-0522-9 |
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