Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) in Preclinical Studies of Antivascular Treatments

• Main Authors: Michael R. Horsman, Thomas Wittenborn, Thomas Nielsen
• Format: Article
• Language: English
• Published: MDPI AG 2012-11-01
• Series: Pharmaceutics
• Subjects: DCE-MRI; angiogenesis inhibitors; vascular disrupting agents; preclinical studies
• Online Access: http://www.mdpi.com/1999-4923/4/4/563

Antivascular treatments can either be antiangiogenic or targeting established tumour vasculature. These treatments affect the tumour microvasculature and microenvironment but may not change clinical measures like tumour volume and growth. In research on antivascular treatments, information on the tumour vasculature is therefore essential. Preclinical research is often used for optimization of antivascular drugs alone or in combined treatments. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is an in vivo imaging method providing vascular information, which has become an important tool in both preclinical and clinical research. This review discusses common DCE-MRI imaging protocols and analysis methods and provides an overview of preclinical research on antivascular treatments utilizing DCE-MRI.