Synthesis and characterization of novel biological tetracoumarin derivatives bearing ether moieties

Synthesis and characterization of novel biological tetracoumarin derivatives bearing ether moieties

A series of novel tetracoumarin derivatives (3a-f) were prepared using the reaction of ether functionalized dibenzaldehyde with 4-hydroxycoumarin in the presence of sodium acetate. The structure of compounds was validated by IR, NMR, and CHN analyzes. Antimicrobial (antibacterial and antifungal) act...

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Main Authors: Behzadi Soheila Asadpour, Sheikhhosseini Enayatollah, Ahmadi Sayed Ali, Ghazanfari Dadkhoda, Akhgar Mohammadreza
Format: Article
Language:English
Published: De Gruyter 2020-04-01
Series:Heterocyclic Communications
Subjects:
tetracoumarin
4-hydroxycoumarin
aqueous media
ethylene ether spacer
biological activity
Online Access:http://www.degruyter.com/view/j/hc.2020.26.issue-1/hc-2020-0009/hc-2020-0009.xml?format=INT
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spelling doaj-de97d8fbcb43479d8b283b8f61b363452021-02-28T21:53:15ZengDe GruyterHeterocyclic Communications2191-01972020-04-01261606710.1515/hc-2020-0009hc-2020-0009Synthesis and characterization of novel biological tetracoumarin derivatives bearing ether moietiesBehzadi Soheila Asadpour0Sheikhhosseini Enayatollah1Ahmadi Sayed Ali2Ghazanfari Dadkhoda3Akhgar Mohammadreza4Department of Chemistry, Kerman Branch, Islamic Azad University, Kerman, IranDepartment of Chemistry, Kerman Branch, Islamic Azad University, Kerman, IranDepartment of Chemistry, Kerman Branch, Islamic Azad University, Kerman, IranDepartment of Chemistry, Kerman Branch, Islamic Azad University, Kerman, IranDepartment of Chemistry, Kerman Branch, Islamic Azad University, Kerman, IranA series of novel tetracoumarin derivatives (3a-f) were prepared using the reaction of ether functionalized dibenzaldehyde with 4-hydroxycoumarin in the presence of sodium acetate. The structure of compounds was validated by IR, NMR, and CHN analyzes. Antimicrobial (antibacterial and antifungal) activity was studied on the basis of the minimum bactericidal concentration, minimum inhibitory concentration and inhibitory zone diameter. Favorable biological activity was found in compound 3f.http://www.degruyter.com/view/j/hc.2020.26.issue-1/hc-2020-0009/hc-2020-0009.xml?format=INTtetracoumarin4-hydroxycoumarinaqueous mediaethylene ether spacerbiological activity
collection DOAJ
language English
format Article
sources DOAJ
author Behzadi Soheila Asadpour
Sheikhhosseini Enayatollah
Ahmadi Sayed Ali
Ghazanfari Dadkhoda
Akhgar Mohammadreza
spellingShingle Behzadi Soheila Asadpour
Sheikhhosseini Enayatollah
Ahmadi Sayed Ali
Ghazanfari Dadkhoda
Akhgar Mohammadreza
Synthesis and characterization of novel biological tetracoumarin derivatives bearing ether moieties
Heterocyclic Communications
tetracoumarin
4-hydroxycoumarin
aqueous media
ethylene ether spacer
biological activity
author_facet Behzadi Soheila Asadpour
Sheikhhosseini Enayatollah
Ahmadi Sayed Ali
Ghazanfari Dadkhoda
Akhgar Mohammadreza
author_sort Behzadi Soheila Asadpour
title Synthesis and characterization of novel biological tetracoumarin derivatives bearing ether moieties
title_short Synthesis and characterization of novel biological tetracoumarin derivatives bearing ether moieties
title_full Synthesis and characterization of novel biological tetracoumarin derivatives bearing ether moieties
title_fullStr Synthesis and characterization of novel biological tetracoumarin derivatives bearing ether moieties
title_full_unstemmed Synthesis and characterization of novel biological tetracoumarin derivatives bearing ether moieties
title_sort synthesis and characterization of novel biological tetracoumarin derivatives bearing ether moieties
publisher De Gruyter
series Heterocyclic Communications
issn 2191-0197
publishDate 2020-04-01
description A series of novel tetracoumarin derivatives (3a-f) were prepared using the reaction of ether functionalized dibenzaldehyde with 4-hydroxycoumarin in the presence of sodium acetate. The structure of compounds was validated by IR, NMR, and CHN analyzes. Antimicrobial (antibacterial and antifungal) activity was studied on the basis of the minimum bactericidal concentration, minimum inhibitory concentration and inhibitory zone diameter. Favorable biological activity was found in compound 3f.
topic tetracoumarin
4-hydroxycoumarin
aqueous media
ethylene ether spacer
biological activity
url http://www.degruyter.com/view/j/hc.2020.26.issue-1/hc-2020-0009/hc-2020-0009.xml?format=INT
work_keys_str_mv AT behzadisoheilaasadpour synthesisandcharacterizationofnovelbiologicaltetracoumarinderivativesbearingethermoieties
AT sheikhhosseinienayatollah synthesisandcharacterizationofnovelbiologicaltetracoumarinderivativesbearingethermoieties
AT ahmadisayedali synthesisandcharacterizationofnovelbiologicaltetracoumarinderivativesbearingethermoieties
AT ghazanfaridadkhoda synthesisandcharacterizationofnovelbiologicaltetracoumarinderivativesbearingethermoieties
AT akhgarmohammadreza synthesisandcharacterizationofnovelbiologicaltetracoumarinderivativesbearingethermoieties
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