Is butyrate a natural alternative to dexamethasone in the management of CoVID-19? [version 1; peer review: 2 approved]
Coronavirus disease 2019 (CoVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 has affected more than 100 million lives. Severe CoVID-19 infection may lead to acute respiratory distress syndrome and death of the patient, and is associated with hyperinflammation and cytokine storm. The...
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doaj-de99cfa3bb9a44b1a871022eedd6ff012021-05-11T12:23:35ZengF1000 Research LtdF1000Research2046-14022021-04-011010.12688/f1000research.51786.154991Is butyrate a natural alternative to dexamethasone in the management of CoVID-19? [version 1; peer review: 2 approved]Nithin K. K0Prakash Patil1Satheesh Kumar Bhandary2Vikram Haridas3Suchetha Kumari N4Sarathkumar E5Praveenkumar Shetty6Division of Proteomics and Cancer Biology, Nitte University Center for Science Education and Research, Nitte (Deemed to be University), Mangaluru, Karnataka, 575018, IndiaCentral Research Laboratory, K S Hegde Medical Academy, Nitte (Deemed to be University), Mangaluru, Karnataka, 575018, IndiaDepartment of ENT, Justice K S Hegde Charitable Hospital, Nitte (Deemed to be University), Mangaluru, Karnataka, 575018, IndiaArthritis Superspeciality Center, Hublic, Karnataka, 580020, IndiaDepartment of Biochemistry/Central Research Laboratory, K S Hegde Medical Academy, Nitte (Deemed to be University), Mangaluru, Karnataka, 575018, IndiaDivision of Proteomics and Cancer Biology, Nitte University Center for Science Education and Research, Nitte (Deemed to be University), Mangaluru, Karnataka, 575018, IndiaDepartment of Biochemistry/Central Research Laboratory, K S Hegde Medical Academy, Nitte (Deemed to be University), Mangaluru, Karnataka, 575018, IndiaCoronavirus disease 2019 (CoVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 has affected more than 100 million lives. Severe CoVID-19 infection may lead to acute respiratory distress syndrome and death of the patient, and is associated with hyperinflammation and cytokine storm. The broad spectrum immunosuppressant corticosteroid, dexamethasone, is being used to manage the cytokine storm and hyperinflammation in CoVID-19 patients. However, the extensive use of corticosteroids leads to serious adverse events and disruption of the gut-lung axis. Various micronutrients and probiotic supplementations are known to aid in the reduction of hyperinflammation and restoration of gut microbiota. The attenuation of the deleterious immune response and hyperinflammation could be mediated by short chain fatty acids produced by the gut microbiota. Butyric acid, the most extensively studied short chain fatty acid, is known for its anti-inflammatory properties. Additionally, butyric acid has been shown to ameliorate hyperinflammation and reduce oxidative stress in various pathologies, including respiratory viral infections. In this review, the potential anti-inflammatory effects of butyric acid that aid in cytokine storm depletion, and its usefulness in effective management of critical illness related to CoVID-19 have been discussed.https://f1000research.com/articles/10-273/v1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nithin K. K Prakash Patil Satheesh Kumar Bhandary Vikram Haridas Suchetha Kumari N Sarathkumar E Praveenkumar Shetty |
spellingShingle |
Nithin K. K Prakash Patil Satheesh Kumar Bhandary Vikram Haridas Suchetha Kumari N Sarathkumar E Praveenkumar Shetty Is butyrate a natural alternative to dexamethasone in the management of CoVID-19? [version 1; peer review: 2 approved] F1000Research |
author_facet |
Nithin K. K Prakash Patil Satheesh Kumar Bhandary Vikram Haridas Suchetha Kumari N Sarathkumar E Praveenkumar Shetty |
author_sort |
Nithin K. K |
title |
Is butyrate a natural alternative to dexamethasone in the management of CoVID-19? [version 1; peer review: 2 approved] |
title_short |
Is butyrate a natural alternative to dexamethasone in the management of CoVID-19? [version 1; peer review: 2 approved] |
title_full |
Is butyrate a natural alternative to dexamethasone in the management of CoVID-19? [version 1; peer review: 2 approved] |
title_fullStr |
Is butyrate a natural alternative to dexamethasone in the management of CoVID-19? [version 1; peer review: 2 approved] |
title_full_unstemmed |
Is butyrate a natural alternative to dexamethasone in the management of CoVID-19? [version 1; peer review: 2 approved] |
title_sort |
is butyrate a natural alternative to dexamethasone in the management of covid-19? [version 1; peer review: 2 approved] |
publisher |
F1000 Research Ltd |
series |
F1000Research |
issn |
2046-1402 |
publishDate |
2021-04-01 |
description |
Coronavirus disease 2019 (CoVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 has affected more than 100 million lives. Severe CoVID-19 infection may lead to acute respiratory distress syndrome and death of the patient, and is associated with hyperinflammation and cytokine storm. The broad spectrum immunosuppressant corticosteroid, dexamethasone, is being used to manage the cytokine storm and hyperinflammation in CoVID-19 patients. However, the extensive use of corticosteroids leads to serious adverse events and disruption of the gut-lung axis. Various micronutrients and probiotic supplementations are known to aid in the reduction of hyperinflammation and restoration of gut microbiota. The attenuation of the deleterious immune response and hyperinflammation could be mediated by short chain fatty acids produced by the gut microbiota. Butyric acid, the most extensively studied short chain fatty acid, is known for its anti-inflammatory properties. Additionally, butyric acid has been shown to ameliorate hyperinflammation and reduce oxidative stress in various pathologies, including respiratory viral infections. In this review, the potential anti-inflammatory effects of butyric acid that aid in cytokine storm depletion, and its usefulness in effective management of critical illness related to CoVID-19 have been discussed. |
url |
https://f1000research.com/articles/10-273/v1 |
work_keys_str_mv |
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