CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors

CAR T-cell therapy efficacy in solid tumors is limited by inadequate T-cell migration and/or persistence in tumour microenvironment. Here, the authors show that the activity of tumour-antigen specific CAR T cells, in multiple preclinical mouse models, can be enhanced by co-expression of two IL-8 rec...

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Main Authors:	Linchun Jin, Haipeng Tao, Aida Karachi, Yu Long, Alicia Y. Hou, Meng Na, Kyle A. Dyson, Adam J. Grippin, Loic P. Deleyrolle, Wang Zhang, Didier A. Rajon, Qiong J. Wang, James C. Yang, Jesse L. Kresak, Elias J. Sayour, Maryam Rahman, Frank J. Bova, Zhiguo Lin, Duane A. Mitchell, Jianping Huang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-11869-4

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spelling	doaj-de9a908e5e6e46b0b45bc79a9225470e2021-05-11T12:30:44ZengNature Publishing GroupNature Communications2041-17232019-09-0110111310.1038/s41467-019-11869-4CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumorsLinchun Jin0Haipeng Tao1Aida Karachi2Yu Long3Alicia Y. Hou4Meng Na5Kyle A. Dyson6Adam J. Grippin7Loic P. Deleyrolle8Wang Zhang9Didier A. Rajon10Qiong J. Wang11James C. Yang12Jesse L. Kresak13Elias J. Sayour14Maryam Rahman15Frank J. Bova16Zhiguo Lin17Duane A. Mitchell18Jianping Huang19Lillian S. Wells Department of Neurosurgery, University of FloridaThe Fourth Section of Department of Neurosurgery, the First Affiliated Hospital, Harbin Medical UniversityLillian S. Wells Department of Neurosurgery, University of FloridaLillian S. Wells Department of Neurosurgery, University of FloridaLillian S. Wells Department of Neurosurgery, University of FloridaThe Fourth Section of Department of Neurosurgery, the First Affiliated Hospital, Harbin Medical UniversityLillian S. Wells Department of Neurosurgery, University of FloridaLillian S. Wells Department of Neurosurgery, University of FloridaLillian S. Wells Department of Neurosurgery, University of FloridaThe Fourth Section of Department of Neurosurgery, the First Affiliated Hospital, Harbin Medical UniversityLillian S. Wells Department of Neurosurgery, University of FloridaThe Surgery Branch, National Cancer InstituteThe Surgery Branch, National Cancer InstituteDepartment of Pathology, Immunology and Laboratory Medicine, University of FloridaLillian S. Wells Department of Neurosurgery, University of FloridaLillian S. Wells Department of Neurosurgery, University of FloridaLillian S. Wells Department of Neurosurgery, University of FloridaThe Fourth Section of Department of Neurosurgery, the First Affiliated Hospital, Harbin Medical UniversityLillian S. Wells Department of Neurosurgery, University of FloridaLillian S. Wells Department of Neurosurgery, University of FloridaCAR T-cell therapy efficacy in solid tumors is limited by inadequate T-cell migration and/or persistence in tumour microenvironment. Here, the authors show that the activity of tumour-antigen specific CAR T cells, in multiple preclinical mouse models, can be enhanced by co-expression of two IL-8 receptors that mediate their migration into the tumor microenvironment when IL-8 production in tumor is naturally expressed or enhanced by radiation.https://doi.org/10.1038/s41467-019-11869-4
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Linchun Jin Haipeng Tao Aida Karachi Yu Long Alicia Y. Hou Meng Na Kyle A. Dyson Adam J. Grippin Loic P. Deleyrolle Wang Zhang Didier A. Rajon Qiong J. Wang James C. Yang Jesse L. Kresak Elias J. Sayour Maryam Rahman Frank J. Bova Zhiguo Lin Duane A. Mitchell Jianping Huang
spellingShingle	Linchun Jin Haipeng Tao Aida Karachi Yu Long Alicia Y. Hou Meng Na Kyle A. Dyson Adam J. Grippin Loic P. Deleyrolle Wang Zhang Didier A. Rajon Qiong J. Wang James C. Yang Jesse L. Kresak Elias J. Sayour Maryam Rahman Frank J. Bova Zhiguo Lin Duane A. Mitchell Jianping Huang CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors Nature Communications
author_facet	Linchun Jin Haipeng Tao Aida Karachi Yu Long Alicia Y. Hou Meng Na Kyle A. Dyson Adam J. Grippin Loic P. Deleyrolle Wang Zhang Didier A. Rajon Qiong J. Wang James C. Yang Jesse L. Kresak Elias J. Sayour Maryam Rahman Frank J. Bova Zhiguo Lin Duane A. Mitchell Jianping Huang
author_sort	Linchun Jin
title	CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors
title_short	CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors
title_full	CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors
title_fullStr	CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors
title_full_unstemmed	CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors
title_sort	cxcr1- or cxcr2-modified car t cells co-opt il-8 for maximal antitumor efficacy in solid tumors
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-09-01
description	CAR T-cell therapy efficacy in solid tumors is limited by inadequate T-cell migration and/or persistence in tumour microenvironment. Here, the authors show that the activity of tumour-antigen specific CAR T cells, in multiple preclinical mouse models, can be enhanced by co-expression of two IL-8 receptors that mediate their migration into the tumor microenvironment when IL-8 production in tumor is naturally expressed or enhanced by radiation.
url	https://doi.org/10.1038/s41467-019-11869-4
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CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors

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