Therapeutic potential of boosting NAD+ in aging and age-related diseases

Therapeutic potential of boosting NAD+ in aging and age-related diseases

Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor in all living cells that is involved in fundamental biological processes. NAD+ depletion has been associated with hallmarks of aging and may underlie a wide-range of age-related diseases, such as metabolic disorders, cancer and neurod...

Full description

Bibliographic Details
Main Authors: Yahyah Aman, Yumin Qiu, Jun Tao, Evandro F. Fang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2018-01-01
Series:Translational Medicine of Aging
Online Access:http://www.sciencedirect.com/science/article/pii/S2468501118300063
id doaj-dea3866284a54a12a77335bf9e273c9d
record_format Article
spelling doaj-dea3866284a54a12a77335bf9e273c9d2021-02-02T04:28:42ZengKeAi Communications Co., Ltd.Translational Medicine of Aging2468-50112018-01-0123037Therapeutic potential of boosting NAD+ in aging and age-related diseasesYahyah Aman0Yumin Qiu1Jun Tao2Evandro F. Fang3Department of Clinical Molecular Biology, University of Oslo, Akershus University Hospital, 1478, Lørenskog, NorwayDepartment of Hypertension and Vascular Disease, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, ChinaDepartment of Hypertension and Vascular Disease, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, ChinaDepartment of Clinical Molecular Biology, University of Oslo, Akershus University Hospital, 1478, Lørenskog, Norway; Department of Hypertension and Vascular Disease, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China; Institute of Geriatric Immunology, School of Medicine, Jinan University, 510632, China; Corresponding author. Department of Clinical Molecular Biology, University of Oslo, Akershus University Hospital, 1478, Lørenskog, Norway.Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor in all living cells that is involved in fundamental biological processes. NAD+ depletion has been associated with hallmarks of aging and may underlie a wide-range of age-related diseases, such as metabolic disorders, cancer and neurodegenerative diseases. Emerging evidence implicates that elevation of NAD+ levels may slow or even reverse the aspects of aging and also delay the progression of age-related diseases. Here we discuss the roles of NAD+-synthesizing and -consuming enzymes in relationships to aging and major age-related diseases. Specifically, we highlight the contribution of NAD+ depletion to aging and evaluate how boosting NAD+ levels may emerge as a promising therapeutic strategy to counter aging-associated pathologies and/or accelerated aging. Keywords: NAD+, Aging, Age-related diseases, Autophagy, Alzheimer's disease, Neurodegeneration, Therapeutic potentialhttp://www.sciencedirect.com/science/article/pii/S2468501118300063
collection DOAJ
language English
format Article
sources DOAJ
author Yahyah Aman
Yumin Qiu
Jun Tao
Evandro F. Fang
spellingShingle Yahyah Aman
Yumin Qiu
Jun Tao
Evandro F. Fang
Therapeutic potential of boosting NAD+ in aging and age-related diseases
Translational Medicine of Aging
author_facet Yahyah Aman
Yumin Qiu
Jun Tao
Evandro F. Fang
author_sort Yahyah Aman
title Therapeutic potential of boosting NAD+ in aging and age-related diseases
title_short Therapeutic potential of boosting NAD+ in aging and age-related diseases
title_full Therapeutic potential of boosting NAD+ in aging and age-related diseases
title_fullStr Therapeutic potential of boosting NAD+ in aging and age-related diseases
title_full_unstemmed Therapeutic potential of boosting NAD+ in aging and age-related diseases
title_sort therapeutic potential of boosting nad+ in aging and age-related diseases
publisher KeAi Communications Co., Ltd.
series Translational Medicine of Aging
issn 2468-5011
publishDate 2018-01-01
description Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor in all living cells that is involved in fundamental biological processes. NAD+ depletion has been associated with hallmarks of aging and may underlie a wide-range of age-related diseases, such as metabolic disorders, cancer and neurodegenerative diseases. Emerging evidence implicates that elevation of NAD+ levels may slow or even reverse the aspects of aging and also delay the progression of age-related diseases. Here we discuss the roles of NAD+-synthesizing and -consuming enzymes in relationships to aging and major age-related diseases. Specifically, we highlight the contribution of NAD+ depletion to aging and evaluate how boosting NAD+ levels may emerge as a promising therapeutic strategy to counter aging-associated pathologies and/or accelerated aging. Keywords: NAD+, Aging, Age-related diseases, Autophagy, Alzheimer's disease, Neurodegeneration, Therapeutic potential
url http://www.sciencedirect.com/science/article/pii/S2468501118300063
work_keys_str_mv AT yahyahaman therapeuticpotentialofboostingnadinagingandagerelateddiseases
AT yuminqiu therapeuticpotentialofboostingnadinagingandagerelateddiseases
AT juntao therapeuticpotentialofboostingnadinagingandagerelateddiseases
AT evandroffang therapeuticpotentialofboostingnadinagingandagerelateddiseases
_version_ 1724305794585853952

Similar Items