Predictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the AMD Annals initiative
Abstract We evaluated 2,656 patients with type 1 diabetes mellitus and preserved renal function from the database of the Italian Association of Clinical Diabetologists network to identify clinical predictors for the development of chronic kidney disease. We measured estimated glomerular filtration r...
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doaj-dea47f590255476cadea339397e8756a2020-12-08T02:08:08ZengNature Publishing GroupScientific Reports2045-23222017-06-01711910.1038/s41598-017-03551-wPredictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the AMD Annals initiativePamela Piscitelli0Francesca Viazzi1Paola Fioretto2Carlo Giorda3Antonio Ceriello4Stefano Genovese5Giuseppina Russo6Pietro Guida7Roberto Pontremoli8Salvatore De Cosmo9Department of Medical Sciences, Scientific Institute “Casa Sollievo della Sofferenza”Università degli Studi and IRCCS Azienda Ospedaliera Universitaria San Martino-ISTDepartment of Medicine, University of PadovaDiabetes and Metabolism Unit ASL Turin 5Institut d’Investigacions Biomèdiques August Pii Sunyer (IDIBAPS) and Centro de Investigación Biomédicaen Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)U.O. Diabetologia e Malattie Metaboliche, Multimedica IRCCS, Sesto San GiovanniDepartment of Clinical and Experimental Medicine, University of MessinaAssociazione Medici DiabetologiUniversità degli Studi and IRCCS Azienda Ospedaliera Universitaria San Martino-ISTDepartment of Medical Sciences, Scientific Institute “Casa Sollievo della Sofferenza”Abstract We evaluated 2,656 patients with type 1 diabetes mellitus and preserved renal function from the database of the Italian Association of Clinical Diabetologists network to identify clinical predictors for the development of chronic kidney disease. We measured estimated glomerular filtration rate (eGFR), urinary albumin excretion, HbA1c, lipids, blood pressure. Over a 5-year period 4.3% (n = 115) developed reduced eGFR (<60 ml/min/1.73 m2), 18.0% (n = 477) albuminuria, and 21.0% (n = 559) either one of the renal endpoints (CKD). Odds ratios for eGFR below 90 mL/min/1.73 m2 (1.48, P < 0.001), HbA1c (1.13, P = 0.002), triglycerides (1.04, P = 0.021 by 20 mg/dL), low density lipoprotein cholesterol (LDL-c) (0.95, P = 0.002 by 10 mg/dL) were independently related to the onset of CKD. Known duration of diabetes (1.15, P = 0.014 by 10 years), HbA1c (1.16, P = 0.001), triglycerides (1.05, P = 0.005 by 20 mg/dL), LDL-c (0.95, P = 0.003 by 10 mg/dL), antihypertensive treatment (2.28, P = 0.018) were related to the onset of albuminuria while age and presence of baseline eGFR values between 90 and 60 mL/min/1.73 m2, independently affected the developing of reduced eGFR (OR 1.95, P < 0.001 by 10 years and 2.92, P < 0.001). Patients with type 1 diabetes mellitus and unfavorable CV risk profile are at high risk of developing CKD. The two main traits of CKD share several determinants, although with some specificities.https://doi.org/10.1038/s41598-017-03551-w |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pamela Piscitelli Francesca Viazzi Paola Fioretto Carlo Giorda Antonio Ceriello Stefano Genovese Giuseppina Russo Pietro Guida Roberto Pontremoli Salvatore De Cosmo |
spellingShingle |
Pamela Piscitelli Francesca Viazzi Paola Fioretto Carlo Giorda Antonio Ceriello Stefano Genovese Giuseppina Russo Pietro Guida Roberto Pontremoli Salvatore De Cosmo Predictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the AMD Annals initiative Scientific Reports |
author_facet |
Pamela Piscitelli Francesca Viazzi Paola Fioretto Carlo Giorda Antonio Ceriello Stefano Genovese Giuseppina Russo Pietro Guida Roberto Pontremoli Salvatore De Cosmo |
author_sort |
Pamela Piscitelli |
title |
Predictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the AMD Annals initiative |
title_short |
Predictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the AMD Annals initiative |
title_full |
Predictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the AMD Annals initiative |
title_fullStr |
Predictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the AMD Annals initiative |
title_full_unstemmed |
Predictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the AMD Annals initiative |
title_sort |
predictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the amd annals initiative |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2017-06-01 |
description |
Abstract We evaluated 2,656 patients with type 1 diabetes mellitus and preserved renal function from the database of the Italian Association of Clinical Diabetologists network to identify clinical predictors for the development of chronic kidney disease. We measured estimated glomerular filtration rate (eGFR), urinary albumin excretion, HbA1c, lipids, blood pressure. Over a 5-year period 4.3% (n = 115) developed reduced eGFR (<60 ml/min/1.73 m2), 18.0% (n = 477) albuminuria, and 21.0% (n = 559) either one of the renal endpoints (CKD). Odds ratios for eGFR below 90 mL/min/1.73 m2 (1.48, P < 0.001), HbA1c (1.13, P = 0.002), triglycerides (1.04, P = 0.021 by 20 mg/dL), low density lipoprotein cholesterol (LDL-c) (0.95, P = 0.002 by 10 mg/dL) were independently related to the onset of CKD. Known duration of diabetes (1.15, P = 0.014 by 10 years), HbA1c (1.16, P = 0.001), triglycerides (1.05, P = 0.005 by 20 mg/dL), LDL-c (0.95, P = 0.003 by 10 mg/dL), antihypertensive treatment (2.28, P = 0.018) were related to the onset of albuminuria while age and presence of baseline eGFR values between 90 and 60 mL/min/1.73 m2, independently affected the developing of reduced eGFR (OR 1.95, P < 0.001 by 10 years and 2.92, P < 0.001). Patients with type 1 diabetes mellitus and unfavorable CV risk profile are at high risk of developing CKD. The two main traits of CKD share several determinants, although with some specificities. |
url |
https://doi.org/10.1038/s41598-017-03551-w |
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