Key MicroRNA’s and Their Targetome in Adrenocortical Cancer

Key MicroRNA’s and Their Targetome in Adrenocortical Cancer

Adrenocortical Carcinoma (ACC) is a rare but aggressive malignancy with poor prognosis and limited response to available systemic therapies. Although complete surgical resection gives the best chance for long-term survival, ACC has a two-year recurrence rate of 50%, which poses a therapeutic challen...

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Main Authors: Marthe Chehade, Martyn Bullock, Anthony Glover, Gyorgy Hutvagner, Stan Sidhu
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
adrenocortical carcinoma
micro RNA
non-coding RNA
Online Access:https://www.mdpi.com/2072-6694/12/8/2198
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spelling doaj-deabc83c05ab4cf2946ab55c36c68a682020-11-25T03:57:25ZengMDPI AGCancers2072-66942020-08-01122198219810.3390/cancers12082198Key MicroRNA’s and Their Targetome in Adrenocortical CancerMarthe Chehade0Martyn Bullock1Anthony Glover2Gyorgy Hutvagner3Stan Sidhu4Cancer Genetics Laboratory, Kolling Institute, Northern Sydney Local Health District, St. Leonards, NSW 2065, AustraliaCancer Genetics Laboratory, Kolling Institute, Northern Sydney Local Health District, St. Leonards, NSW 2065, AustraliaCancer Genetics Laboratory, Kolling Institute, Northern Sydney Local Health District, St. Leonards, NSW 2065, AustraliaSchool of Biomedical Engineering, Faculty of Engineering and Information Technology, University of Technology Sydney, Sydney, NSW 2007, AustraliaCancer Genetics Laboratory, Kolling Institute, Northern Sydney Local Health District, St. Leonards, NSW 2065, AustraliaAdrenocortical Carcinoma (ACC) is a rare but aggressive malignancy with poor prognosis and limited response to available systemic therapies. Although complete surgical resection gives the best chance for long-term survival, ACC has a two-year recurrence rate of 50%, which poses a therapeutic challenge. High throughput analyses focused on characterizing the molecular signature of ACC have revealed specific micro-RNAs (miRNAs) that are associated with aggressive tumor phenotypes. MiRNAs are small non-coding RNA molecules that regulate gene expression by inhibiting mRNA translation or degrading mRNA transcripts and have been generally implicated in carcinogenesis. This review summarizes the current insights into dysregulated miRNAs in ACC tumorigenesis, their known functions, and specific targetomes. In addition, we explore the possibility of particular miRNAs to be exploited as clinical biomarkers in ACC and as potential therapeutics.https://www.mdpi.com/2072-6694/12/8/2198adrenocortical carcinomamicro RNAnon-coding RNA
collection DOAJ
language English
format Article
sources DOAJ
author Marthe Chehade
Martyn Bullock
Anthony Glover
Gyorgy Hutvagner
Stan Sidhu
spellingShingle Marthe Chehade
Martyn Bullock
Anthony Glover
Gyorgy Hutvagner
Stan Sidhu
Key MicroRNA’s and Their Targetome in Adrenocortical Cancer
Cancers
adrenocortical carcinoma
micro RNA
non-coding RNA
author_facet Marthe Chehade
Martyn Bullock
Anthony Glover
Gyorgy Hutvagner
Stan Sidhu
author_sort Marthe Chehade
title Key MicroRNA’s and Their Targetome in Adrenocortical Cancer
title_short Key MicroRNA’s and Their Targetome in Adrenocortical Cancer
title_full Key MicroRNA’s and Their Targetome in Adrenocortical Cancer
title_fullStr Key MicroRNA’s and Their Targetome in Adrenocortical Cancer
title_full_unstemmed Key MicroRNA’s and Their Targetome in Adrenocortical Cancer
title_sort key microrna’s and their targetome in adrenocortical cancer
publisher MDPI AG
series Cancers
issn 2072-6694
publishDate 2020-08-01
description Adrenocortical Carcinoma (ACC) is a rare but aggressive malignancy with poor prognosis and limited response to available systemic therapies. Although complete surgical resection gives the best chance for long-term survival, ACC has a two-year recurrence rate of 50%, which poses a therapeutic challenge. High throughput analyses focused on characterizing the molecular signature of ACC have revealed specific micro-RNAs (miRNAs) that are associated with aggressive tumor phenotypes. MiRNAs are small non-coding RNA molecules that regulate gene expression by inhibiting mRNA translation or degrading mRNA transcripts and have been generally implicated in carcinogenesis. This review summarizes the current insights into dysregulated miRNAs in ACC tumorigenesis, their known functions, and specific targetomes. In addition, we explore the possibility of particular miRNAs to be exploited as clinical biomarkers in ACC and as potential therapeutics.
topic adrenocortical carcinoma
micro RNA
non-coding RNA
url https://www.mdpi.com/2072-6694/12/8/2198
work_keys_str_mv AT marthechehade keymicrornasandtheirtargetomeinadrenocorticalcancer
AT martynbullock keymicrornasandtheirtargetomeinadrenocorticalcancer
AT anthonyglover keymicrornasandtheirtargetomeinadrenocorticalcancer
AT gyorgyhutvagner keymicrornasandtheirtargetomeinadrenocorticalcancer
AT stansidhu keymicrornasandtheirtargetomeinadrenocorticalcancer
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