Risk Factors of Antituberculosis Induced-Hepatotoxicity among HIV/AIDS Patients

Introduction. Antituberculosis (ATT) induced hepatotoxicity is commonly found among HIV/AIDS patients. Several risk factor related to drug-induced hepatotoxicity such as alcoholism, hepatitis B or hepatitis C infection, abnormal baseline aminotransferase/bilirubin, poor nutritional status and concom...

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Main Authors: Lies Luthariana, Teguh H. Karjadi, Irsan Hasan, C. Martin Rumende
Format: Article
Language:Indonesian
Published: Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital 2017-03-01
Series:Jurnal Penyakit Dalam Indonesia
Subjects:
Online Access:http://jurnalpenyakitdalam.ui.ac.id/index.php/jpdi/article/view/109/99
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spelling doaj-deb279b2e6b94efe82736e40a348e3a42020-11-25T00:15:58ZindDepartment of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo HospitalJurnal Penyakit Dalam Indonesia2406-89692549-06212017-03-01412328http://dx.doi.org/10.7454/jpdi.v4i1.109Risk Factors of Antituberculosis Induced-Hepatotoxicity among HIV/AIDS PatientsLies Luthariana0Teguh H. Karjadi1Irsan Hasan2C. Martin Rumende3Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Indonesia/RSCM, Jakarta Indonesia Divisi Alergi-Imunologi Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Indonesia/RSCM, Jakarta IndonesiaDivisi Hepatologi Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Indonesia/RSCM, Jakarta IndonesiaUnit Epidemiologi, Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Indonesia/RSCM, Jakarta Indonesia Introduction. Antituberculosis (ATT) induced hepatotoxicity is commonly found among HIV/AIDS patients. Several risk factor related to drug-induced hepatotoxicity such as alcoholism, hepatitis B or hepatitis C infection, abnormal baseline aminotransferase/bilirubin, poor nutritional status and concomitant hepatotoxic drugs consumption, are usually found in these patients. This study was conducted to evaluate risk factor of ATT-induced hepatotoxicity in HIV/AIDS patients. Methods. This is a case control retrospective study with matching of age, sex, antituberculosis regimen, and alcohol consumption. Risk factors evaluated are hepatitis C and hepatitis B coinfection, concomitant hepatotoxic drugs consumption, abnormal baseline aminotransferase and or bilirubin. Results. We collected data of 33 cases and 33 controls We found 82% subjects in case group and 76% subjects in control group have hepatitis C coinfection; 18% subjects in case group and 6% subjects in control group have hepatitis B coinfection. Fifty four point five percent (54.5%) subjects in case group and 42.4% subjects in control group consume other hepatotoxic drugs. Elevated baseline ALT level was found in 51.5% subjects in case group and 12% subject in control group. Bivariate analysis showed that the risk of hepatotoxicity was higher in patients with elevated baseline ALT level (OR=7.5; 95% CI 1,7232,80; p < 0,05). Conclusions. Elevated baseline ALT level will increase antituberculosis drug induce hepatotoxicity risk up to 7.5 times. There were no association between hepatitis C, hepatitis B, concomitant hepatotoxic drugs consumption and antituberculosis drug-induced hepatotoxicity in HIV/AIDS patients.http://jurnalpenyakitdalam.ui.ac.id/index.php/jpdi/article/view/109/99antituberculosis-induced hepatotoxicityHIV/AIDStuberculosis
collection DOAJ
language Indonesian
format Article
sources DOAJ
author Lies Luthariana
Teguh H. Karjadi
Irsan Hasan
C. Martin Rumende
spellingShingle Lies Luthariana
Teguh H. Karjadi
Irsan Hasan
C. Martin Rumende
Risk Factors of Antituberculosis Induced-Hepatotoxicity among HIV/AIDS Patients
Jurnal Penyakit Dalam Indonesia
antituberculosis-induced hepatotoxicity
HIV/AIDS
tuberculosis
author_facet Lies Luthariana
Teguh H. Karjadi
Irsan Hasan
C. Martin Rumende
author_sort Lies Luthariana
title Risk Factors of Antituberculosis Induced-Hepatotoxicity among HIV/AIDS Patients
title_short Risk Factors of Antituberculosis Induced-Hepatotoxicity among HIV/AIDS Patients
title_full Risk Factors of Antituberculosis Induced-Hepatotoxicity among HIV/AIDS Patients
title_fullStr Risk Factors of Antituberculosis Induced-Hepatotoxicity among HIV/AIDS Patients
title_full_unstemmed Risk Factors of Antituberculosis Induced-Hepatotoxicity among HIV/AIDS Patients
title_sort risk factors of antituberculosis induced-hepatotoxicity among hiv/aids patients
publisher Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital
series Jurnal Penyakit Dalam Indonesia
issn 2406-8969
2549-0621
publishDate 2017-03-01
description Introduction. Antituberculosis (ATT) induced hepatotoxicity is commonly found among HIV/AIDS patients. Several risk factor related to drug-induced hepatotoxicity such as alcoholism, hepatitis B or hepatitis C infection, abnormal baseline aminotransferase/bilirubin, poor nutritional status and concomitant hepatotoxic drugs consumption, are usually found in these patients. This study was conducted to evaluate risk factor of ATT-induced hepatotoxicity in HIV/AIDS patients. Methods. This is a case control retrospective study with matching of age, sex, antituberculosis regimen, and alcohol consumption. Risk factors evaluated are hepatitis C and hepatitis B coinfection, concomitant hepatotoxic drugs consumption, abnormal baseline aminotransferase and or bilirubin. Results. We collected data of 33 cases and 33 controls We found 82% subjects in case group and 76% subjects in control group have hepatitis C coinfection; 18% subjects in case group and 6% subjects in control group have hepatitis B coinfection. Fifty four point five percent (54.5%) subjects in case group and 42.4% subjects in control group consume other hepatotoxic drugs. Elevated baseline ALT level was found in 51.5% subjects in case group and 12% subject in control group. Bivariate analysis showed that the risk of hepatotoxicity was higher in patients with elevated baseline ALT level (OR=7.5; 95% CI 1,7232,80; p < 0,05). Conclusions. Elevated baseline ALT level will increase antituberculosis drug induce hepatotoxicity risk up to 7.5 times. There were no association between hepatitis C, hepatitis B, concomitant hepatotoxic drugs consumption and antituberculosis drug-induced hepatotoxicity in HIV/AIDS patients.
topic antituberculosis-induced hepatotoxicity
HIV/AIDS
tuberculosis
url http://jurnalpenyakitdalam.ui.ac.id/index.php/jpdi/article/view/109/99
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