Evaluation of Risk Factors for Carbapenem-Resistant Klebsiella Pneumoniae Bacteremia

INTRODUCTION[|]In recent years, carbapenem-resistant Klebsiella pneumoniae infections have become an important health problem in our country and all over the world. In this study, we aimed to identify the risk factors of carbapenem-resistant K. pneumoniae bacteremia.[¤]METHODS[|]Patients who suffere...

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Main Authors: Pınar Kıran, Serap Gencer, Ayşe Batırel
Format: Article
Language:English
Published: KARE Publishing 2020-03-01
Series:Southern Clinics of Istanbul Eurasia
Subjects:
Online Access:https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=SCIE-48569
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spelling doaj-deb9cd919e1d46cd8161b399fe6ed6d22021-01-24T18:11:48ZengKARE PublishingSouthern Clinics of Istanbul Eurasia2587-09982020-03-01311545810.14744/scie.2019.48569SCIE-48569Evaluation of Risk Factors for Carbapenem-Resistant Klebsiella Pneumoniae BacteremiaPınar Kıran0Serap Gencer1Ayşe Batırel2Department of Infectious Diseases, Çan State Hospital, Çanakkale, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Acıbadem Mehmet Ali Aydınlar University Maslak Hospital, İstanbul, TurkeyDepartment of Infectious Diseases, University of Health Sciences, Kartal Dr. Lütfi Kırdar Training and Research Hospital, İstanbul, TurkeyINTRODUCTION[|]In recent years, carbapenem-resistant Klebsiella pneumoniae infections have become an important health problem in our country and all over the world. In this study, we aimed to identify the risk factors of carbapenem-resistant K. pneumoniae bacteremia.[¤]METHODS[|]Patients who suffered from Klebsiella pneumoniae bacteremia between December 2016 and May 2018 were included prospectively in this study. Patients were divided into groups according to carbapenem resistance and risk factors were analyzed under variable and multivariable logistic regression model.[¤]RESULTS[|]Of the fifty-three patients were included in this study, 27 patients infected with carbapenem-resistant K. pneumoniae and 26 patients infected with carbapenem-suspectible K. pneumoniae. Risk factors for carbapenem-resistant K. pneumoniae bacteremia according to univariate analysis were listed prior hospitalization (p=0.043; OR=3.20; 95% CI: 1.04–9.85), admission to intensive care unit (p=0.001; OR=10.91; 955 CI: 2.61–45.6), use of beta-lactams/beta-lactamase inhibitor combination (p<0.001; OR=41.67; 95% CI: 7.57–229.2) and use of glycopeptides (p=0.001; OR=7.92; 95% CI: 2.31–27.1). Before hospitalization (p=0.016; OR=9.64; 95% CI: 1.54–60.46) and use of beta-lactams/beta-lactamase, inhibitor combination (p<0.001; OR=38.45; 95% CI: 6.04–244.85) were identified as independent risk factors for carbapenem resistance in multivariate analysis.[¤]DISCUSSION AND CONCLUSION[|]According to our study, before hospitalization, the use of beta-lactams/beta-lactamase inhibitor combination was the major risk factor for carbapenem-resistant Klebsiella pneumoniae bacteremia.[¤]https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=SCIE-48569bacteremiacarbapenem; klebsiella pneumoniae; risk factors.
collection DOAJ
language English
format Article
sources DOAJ
author Pınar Kıran
Serap Gencer
Ayşe Batırel
spellingShingle Pınar Kıran
Serap Gencer
Ayşe Batırel
Evaluation of Risk Factors for Carbapenem-Resistant Klebsiella Pneumoniae Bacteremia
Southern Clinics of Istanbul Eurasia
bacteremia
carbapenem; klebsiella pneumoniae; risk factors.
author_facet Pınar Kıran
Serap Gencer
Ayşe Batırel
author_sort Pınar Kıran
title Evaluation of Risk Factors for Carbapenem-Resistant Klebsiella Pneumoniae Bacteremia
title_short Evaluation of Risk Factors for Carbapenem-Resistant Klebsiella Pneumoniae Bacteremia
title_full Evaluation of Risk Factors for Carbapenem-Resistant Klebsiella Pneumoniae Bacteremia
title_fullStr Evaluation of Risk Factors for Carbapenem-Resistant Klebsiella Pneumoniae Bacteremia
title_full_unstemmed Evaluation of Risk Factors for Carbapenem-Resistant Klebsiella Pneumoniae Bacteremia
title_sort evaluation of risk factors for carbapenem-resistant klebsiella pneumoniae bacteremia
publisher KARE Publishing
series Southern Clinics of Istanbul Eurasia
issn 2587-0998
publishDate 2020-03-01
description INTRODUCTION[|]In recent years, carbapenem-resistant Klebsiella pneumoniae infections have become an important health problem in our country and all over the world. In this study, we aimed to identify the risk factors of carbapenem-resistant K. pneumoniae bacteremia.[¤]METHODS[|]Patients who suffered from Klebsiella pneumoniae bacteremia between December 2016 and May 2018 were included prospectively in this study. Patients were divided into groups according to carbapenem resistance and risk factors were analyzed under variable and multivariable logistic regression model.[¤]RESULTS[|]Of the fifty-three patients were included in this study, 27 patients infected with carbapenem-resistant K. pneumoniae and 26 patients infected with carbapenem-suspectible K. pneumoniae. Risk factors for carbapenem-resistant K. pneumoniae bacteremia according to univariate analysis were listed prior hospitalization (p=0.043; OR=3.20; 95% CI: 1.04–9.85), admission to intensive care unit (p=0.001; OR=10.91; 955 CI: 2.61–45.6), use of beta-lactams/beta-lactamase inhibitor combination (p<0.001; OR=41.67; 95% CI: 7.57–229.2) and use of glycopeptides (p=0.001; OR=7.92; 95% CI: 2.31–27.1). Before hospitalization (p=0.016; OR=9.64; 95% CI: 1.54–60.46) and use of beta-lactams/beta-lactamase, inhibitor combination (p<0.001; OR=38.45; 95% CI: 6.04–244.85) were identified as independent risk factors for carbapenem resistance in multivariate analysis.[¤]DISCUSSION AND CONCLUSION[|]According to our study, before hospitalization, the use of beta-lactams/beta-lactamase inhibitor combination was the major risk factor for carbapenem-resistant Klebsiella pneumoniae bacteremia.[¤]
topic bacteremia
carbapenem; klebsiella pneumoniae; risk factors.
url https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=SCIE-48569
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AT aysebatırel evaluationofriskfactorsforcarbapenemresistantklebsiellapneumoniaebacteremia
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