Hybridized Zoonotic <i>Schistosoma</i> Infections Result in Hybridized Morbidity Profiles: A Clinical Morbidity Study amongst Co-Infected Human Populations of Senegal

• Main Authors: Cheikh B. Fall, Sébastien Lambert, Elsa Léger, Lucy Yasenev, Amadou Djirmay Garba, Samba D. Diop, Anna Borlase, Stefano Catalano, Babacar Faye, Martin Walker, Mariama Sene, Joanne P. Webster
• Format: Article
• Language: English
• Published: MDPI AG 2021-08-01
• Series: Microorganisms
• Subjects: hybridization; schistosomiasis; morbidity; ultrasonography; disease control; one health
• Online Access: https://www.mdpi.com/2076-2607/9/8/1776

Hybridization of infectious agents is a major emerging public and veterinary health concern at the interface of evolution, epidemiology, and control. Whilst evidence of the extent of hybridization amongst parasites is increasing, their impact on morbidity remains largely unknown. This may be predicted to be particularly pertinent where parasites of animals with contrasting pathogenicity viably hybridize with human parasites. Recent research has revealed that viable zoonotic hybrids between human urogenital <i>Schistosoma haematobium</i> with intestinal <i>Schistosoma</i> species of livestock, notably <i>Schistosoma bovis,</i> can be highly prevalent across Africa and beyond. Examining human populations in Senegal, we found increased hepatic but decreased urogenital morbidity, and reduced improvement following treatment with praziquantel, in those infected with zoonotic hybrids compared to non-hybrids. Our results have implications for effective monitoring and evaluation of control programmes, and demonstrate for the first time the potential impact of parasite hybridizations on host morbidity.