High atherogenic index of plasma in subclinical hypothyroidism: Implications in assessment of cardiovascular disease risk
Background: A controversy exists regarding the association between subclinical hypothyroidism (SH) and dyslipidemia. Moreover, studies on lipid ratios and atherogenic index of plasma (AIP) in SH are rare, particularly in the Indian scenario. Aim: This study aimed to investigate abnormalities in conv...
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Wolters Kluwer Medknow Publications
2016-01-01
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doaj-decfb106c9444cf695097e4d3c64a7192020-11-24T23:34:44ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102016-01-0120565666110.4103/2230-8210.190550High atherogenic index of plasma in subclinical hypothyroidism: Implications in assessment of cardiovascular disease riskStephen R JamesLopamudra RayKandasamy RavichandranSunil Kumar NandaBackground: A controversy exists regarding the association between subclinical hypothyroidism (SH) and dyslipidemia. Moreover, studies on lipid ratios and atherogenic index of plasma (AIP) in SH are rare, particularly in the Indian scenario. Aim: This study aimed to investigate abnormalities in conventional lipid profile, lipid ratios, and AIP in SH and attempted to correlate thyroid stimulating hormone (TSH) and AIP in SH. Materials and Methods: In this retrospective analysis of patient records of SH subjects and euthyroid subjects, age, free triiodothyronine, free thyroxine, TSH, total cholesterol, triglycerides, high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol, lipid ratios, and AIP were compared between the two groups. The correlation of TSH and AIP in SH was studied. Spearman′s correlation, Mann-Whitney U-test and logistic regression analysis were performed. Results: Triglyceride, triglyceride/HDL-C, and AIP were significantly higher in SH as compared to euthyroid group, but there was no correlation between TSH and AIP in SH. AIP emerged as the significant single factor associated with SH in multiple logistic regressions. Conclusion: The positive association of dyslipidemia and SH indicates a need for regular screening of these patients to enable early diagnosis and treatment of dyslipidemia. Even in patients who have a normal conventional lipid profile, lipid ratios, and AIP have to be calculated for better assessment of atherogenic risk.http://www.ijem.in/article.asp?issn=2230-8210;year=2016;volume=20;issue=5;spage=656;epage=661;aulast=JamesAtherogenic index of plasmadyslipidemialipid profilelipid ratiossubclinical hypothyroidism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stephen R James Lopamudra Ray Kandasamy Ravichandran Sunil Kumar Nanda |
spellingShingle |
Stephen R James Lopamudra Ray Kandasamy Ravichandran Sunil Kumar Nanda High atherogenic index of plasma in subclinical hypothyroidism: Implications in assessment of cardiovascular disease risk Indian Journal of Endocrinology and Metabolism Atherogenic index of plasma dyslipidemia lipid profile lipid ratios subclinical hypothyroidism |
author_facet |
Stephen R James Lopamudra Ray Kandasamy Ravichandran Sunil Kumar Nanda |
author_sort |
Stephen R James |
title |
High atherogenic index of plasma in subclinical hypothyroidism: Implications in assessment of cardiovascular disease risk |
title_short |
High atherogenic index of plasma in subclinical hypothyroidism: Implications in assessment of cardiovascular disease risk |
title_full |
High atherogenic index of plasma in subclinical hypothyroidism: Implications in assessment of cardiovascular disease risk |
title_fullStr |
High atherogenic index of plasma in subclinical hypothyroidism: Implications in assessment of cardiovascular disease risk |
title_full_unstemmed |
High atherogenic index of plasma in subclinical hypothyroidism: Implications in assessment of cardiovascular disease risk |
title_sort |
high atherogenic index of plasma in subclinical hypothyroidism: implications in assessment of cardiovascular disease risk |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Journal of Endocrinology and Metabolism |
issn |
2230-8210 |
publishDate |
2016-01-01 |
description |
Background: A controversy exists regarding the association between subclinical hypothyroidism (SH) and dyslipidemia. Moreover, studies on lipid ratios and atherogenic index of plasma (AIP) in SH are rare, particularly in the Indian scenario. Aim: This study aimed to investigate abnormalities in conventional lipid profile, lipid ratios, and AIP in SH and attempted to correlate thyroid stimulating hormone (TSH) and AIP in SH. Materials and Methods: In this retrospective analysis of patient records of SH subjects and euthyroid subjects, age, free triiodothyronine, free thyroxine, TSH, total cholesterol, triglycerides, high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol, lipid ratios, and AIP were compared between the two groups. The correlation of TSH and AIP in SH was studied. Spearman′s correlation, Mann-Whitney U-test and logistic regression analysis were performed. Results: Triglyceride, triglyceride/HDL-C, and AIP were significantly higher in SH as compared to euthyroid group, but there was no correlation between TSH and AIP in SH. AIP emerged as the significant single factor associated with SH in multiple logistic regressions. Conclusion: The positive association of dyslipidemia and SH indicates a need for regular screening of these patients to enable early diagnosis and treatment of dyslipidemia. Even in patients who have a normal conventional lipid profile, lipid ratios, and AIP have to be calculated for better assessment of atherogenic risk. |
topic |
Atherogenic index of plasma dyslipidemia lipid profile lipid ratios subclinical hypothyroidism |
url |
http://www.ijem.in/article.asp?issn=2230-8210;year=2016;volume=20;issue=5;spage=656;epage=661;aulast=James |
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