Emerging Role of Ferroptosis in Acute Kidney Injury
Acute kidney injury (AKI) is a heterogeneous group of critical disease conditions with high incidence and mortality. Vasoconstriction, oxidative stress, apoptosis, and inflammation are generally thought to be the main pathogenic mechanisms of AKI. Ferroptosis is a type of iron-dependent nonapoptotic...
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doaj-ded0dd39c8664383adc0a9883dbddcea2020-11-25T02:48:25ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09001942-09942019-01-01201910.1155/2019/80106148010614Emerging Role of Ferroptosis in Acute Kidney InjuryZhaoxin Hu0Hao Zhang1Shi-kun Yang2Xueqin Wu3Dong He4Ke Cao5Wei Zhang6Department of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, 410013 Hunan Province, ChinaDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, 410013 Hunan Province, ChinaDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, 410013 Hunan Province, ChinaDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, 410013 Hunan Province, ChinaDepartment of Respiration, The Second People's Hospital of Hunan Province of Hunan University of Chinese Medicine, Changsha, Hunan, ChinaDepartment of Oncology, The Third Xiangya Hospital, Central South University, Changsha, 410013 Hunan Province, ChinaDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, 410013 Hunan Province, ChinaAcute kidney injury (AKI) is a heterogeneous group of critical disease conditions with high incidence and mortality. Vasoconstriction, oxidative stress, apoptosis, and inflammation are generally thought to be the main pathogenic mechanisms of AKI. Ferroptosis is a type of iron-dependent nonapoptotic cell death characterized by membrane lipid peroxide accumulation and polyunsaturated fatty acid consumption, and it plays essential roles in many diseases, including cancers and neurologic diseases. Recent studies have revealed an emerging role of ferroptosis in the pathophysiological processes of AKI. Here, in the present review, we summarized the most recent discoveries on the role of ferroptosis in the pathogenesis of AKI as well as its therapeutic potential in AKI.http://dx.doi.org/10.1155/2019/8010614 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhaoxin Hu Hao Zhang Shi-kun Yang Xueqin Wu Dong He Ke Cao Wei Zhang |
spellingShingle |
Zhaoxin Hu Hao Zhang Shi-kun Yang Xueqin Wu Dong He Ke Cao Wei Zhang Emerging Role of Ferroptosis in Acute Kidney Injury Oxidative Medicine and Cellular Longevity |
author_facet |
Zhaoxin Hu Hao Zhang Shi-kun Yang Xueqin Wu Dong He Ke Cao Wei Zhang |
author_sort |
Zhaoxin Hu |
title |
Emerging Role of Ferroptosis in Acute Kidney Injury |
title_short |
Emerging Role of Ferroptosis in Acute Kidney Injury |
title_full |
Emerging Role of Ferroptosis in Acute Kidney Injury |
title_fullStr |
Emerging Role of Ferroptosis in Acute Kidney Injury |
title_full_unstemmed |
Emerging Role of Ferroptosis in Acute Kidney Injury |
title_sort |
emerging role of ferroptosis in acute kidney injury |
publisher |
Hindawi Limited |
series |
Oxidative Medicine and Cellular Longevity |
issn |
1942-0900 1942-0994 |
publishDate |
2019-01-01 |
description |
Acute kidney injury (AKI) is a heterogeneous group of critical disease conditions with high incidence and mortality. Vasoconstriction, oxidative stress, apoptosis, and inflammation are generally thought to be the main pathogenic mechanisms of AKI. Ferroptosis is a type of iron-dependent nonapoptotic cell death characterized by membrane lipid peroxide accumulation and polyunsaturated fatty acid consumption, and it plays essential roles in many diseases, including cancers and neurologic diseases. Recent studies have revealed an emerging role of ferroptosis in the pathophysiological processes of AKI. Here, in the present review, we summarized the most recent discoveries on the role of ferroptosis in the pathogenesis of AKI as well as its therapeutic potential in AKI. |
url |
http://dx.doi.org/10.1155/2019/8010614 |
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