Emerging Role of Ferroptosis in Acute Kidney Injury

Acute kidney injury (AKI) is a heterogeneous group of critical disease conditions with high incidence and mortality. Vasoconstriction, oxidative stress, apoptosis, and inflammation are generally thought to be the main pathogenic mechanisms of AKI. Ferroptosis is a type of iron-dependent nonapoptotic...

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Main Authors:	Zhaoxin Hu, Hao Zhang, Shi-kun Yang, Xueqin Wu, Dong He, Ke Cao, Wei Zhang
Format:	Article
Language:	English
Published:	Hindawi Limited 2019-01-01
Series:	Oxidative Medicine and Cellular Longevity
Online Access:	http://dx.doi.org/10.1155/2019/8010614

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spelling	doaj-ded0dd39c8664383adc0a9883dbddcea2020-11-25T02:48:25ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09001942-09942019-01-01201910.1155/2019/80106148010614Emerging Role of Ferroptosis in Acute Kidney InjuryZhaoxin Hu0Hao Zhang1Shi-kun Yang2Xueqin Wu3Dong He4Ke Cao5Wei Zhang6Department of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, 410013 Hunan Province, ChinaDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, 410013 Hunan Province, ChinaDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, 410013 Hunan Province, ChinaDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, 410013 Hunan Province, ChinaDepartment of Respiration, The Second People's Hospital of Hunan Province of Hunan University of Chinese Medicine, Changsha, Hunan, ChinaDepartment of Oncology, The Third Xiangya Hospital, Central South University, Changsha, 410013 Hunan Province, ChinaDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, 410013 Hunan Province, ChinaAcute kidney injury (AKI) is a heterogeneous group of critical disease conditions with high incidence and mortality. Vasoconstriction, oxidative stress, apoptosis, and inflammation are generally thought to be the main pathogenic mechanisms of AKI. Ferroptosis is a type of iron-dependent nonapoptotic cell death characterized by membrane lipid peroxide accumulation and polyunsaturated fatty acid consumption, and it plays essential roles in many diseases, including cancers and neurologic diseases. Recent studies have revealed an emerging role of ferroptosis in the pathophysiological processes of AKI. Here, in the present review, we summarized the most recent discoveries on the role of ferroptosis in the pathogenesis of AKI as well as its therapeutic potential in AKI.http://dx.doi.org/10.1155/2019/8010614
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Zhaoxin Hu Hao Zhang Shi-kun Yang Xueqin Wu Dong He Ke Cao Wei Zhang
spellingShingle	Zhaoxin Hu Hao Zhang Shi-kun Yang Xueqin Wu Dong He Ke Cao Wei Zhang Emerging Role of Ferroptosis in Acute Kidney Injury Oxidative Medicine and Cellular Longevity
author_facet	Zhaoxin Hu Hao Zhang Shi-kun Yang Xueqin Wu Dong He Ke Cao Wei Zhang
author_sort	Zhaoxin Hu
title	Emerging Role of Ferroptosis in Acute Kidney Injury
title_short	Emerging Role of Ferroptosis in Acute Kidney Injury
title_full	Emerging Role of Ferroptosis in Acute Kidney Injury
title_fullStr	Emerging Role of Ferroptosis in Acute Kidney Injury
title_full_unstemmed	Emerging Role of Ferroptosis in Acute Kidney Injury
title_sort	emerging role of ferroptosis in acute kidney injury
publisher	Hindawi Limited
series	Oxidative Medicine and Cellular Longevity
issn	1942-0900 1942-0994
publishDate	2019-01-01
description	Acute kidney injury (AKI) is a heterogeneous group of critical disease conditions with high incidence and mortality. Vasoconstriction, oxidative stress, apoptosis, and inflammation are generally thought to be the main pathogenic mechanisms of AKI. Ferroptosis is a type of iron-dependent nonapoptotic cell death characterized by membrane lipid peroxide accumulation and polyunsaturated fatty acid consumption, and it plays essential roles in many diseases, including cancers and neurologic diseases. Recent studies have revealed an emerging role of ferroptosis in the pathophysiological processes of AKI. Here, in the present review, we summarized the most recent discoveries on the role of ferroptosis in the pathogenesis of AKI as well as its therapeutic potential in AKI.
url	http://dx.doi.org/10.1155/2019/8010614
work_keys_str_mv	AT zhaoxinhu emergingroleofferroptosisinacutekidneyinjury AT haozhang emergingroleofferroptosisinacutekidneyinjury AT shikunyang emergingroleofferroptosisinacutekidneyinjury AT xueqinwu emergingroleofferroptosisinacutekidneyinjury AT donghe emergingroleofferroptosisinacutekidneyinjury AT kecao emergingroleofferroptosisinacutekidneyinjury AT weizhang emergingroleofferroptosisinacutekidneyinjury
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Emerging Role of Ferroptosis in Acute Kidney Injury

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