Activity of Alzheimer’s γ-secretase is linked to changes of interferon-induced transmembrane proteins (IFITM) in innate immunity
Abstract The activity of γ-secretase is critical to the pathogenesis of Alzheimer’s disease (AD). How its activity is regulated is intriguing and highly important for any AD therapy that focuses on reduction of toxic amyloid peptides and amyloid deposition in patients. Recently, interferon-induced t...
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BMC
2020-11-01
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| Series: | Molecular Neurodegeneration |
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| Online Access: | http://link.springer.com/article/10.1186/s13024-020-00417-0 |
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doaj-deddeaa1e6ae420aa5da77decd1fbeda2020-11-25T04:07:52ZengBMCMolecular Neurodegeneration1750-13262020-11-011511410.1186/s13024-020-00417-0Activity of Alzheimer’s γ-secretase is linked to changes of interferon-induced transmembrane proteins (IFITM) in innate immunityAnnie Y. Yao0Riqiang Yan1Department of Neuroscience, University of Connecticut HealthDepartment of Neuroscience, University of Connecticut HealthAbstract The activity of γ-secretase is critical to the pathogenesis of Alzheimer’s disease (AD). How its activity is regulated is intriguing and highly important for any AD therapy that focuses on reduction of toxic amyloid peptides and amyloid deposition in patients. Recently, interferon-induced transmembrane protein 3 (IFITM3) has been identified as a novel regulator of γ-secretase through a specific interaction. This commentary highlights this exciting study and provides an updated link of γ-secretase activity to innate immunity through IFITM3.http://link.springer.com/article/10.1186/s13024-020-00417-0Γ-secretasePresenilinNicastrinInterferon-induced transmembrane proteinIFITM3Innate immunity |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Annie Y. Yao Riqiang Yan |
| spellingShingle |
Annie Y. Yao Riqiang Yan Activity of Alzheimer’s γ-secretase is linked to changes of interferon-induced transmembrane proteins (IFITM) in innate immunity Molecular Neurodegeneration Γ-secretase Presenilin Nicastrin Interferon-induced transmembrane protein IFITM3 Innate immunity |
| author_facet |
Annie Y. Yao Riqiang Yan |
| author_sort |
Annie Y. Yao |
| title |
Activity of Alzheimer’s γ-secretase is linked to changes of interferon-induced transmembrane proteins (IFITM) in innate immunity |
| title_short |
Activity of Alzheimer’s γ-secretase is linked to changes of interferon-induced transmembrane proteins (IFITM) in innate immunity |
| title_full |
Activity of Alzheimer’s γ-secretase is linked to changes of interferon-induced transmembrane proteins (IFITM) in innate immunity |
| title_fullStr |
Activity of Alzheimer’s γ-secretase is linked to changes of interferon-induced transmembrane proteins (IFITM) in innate immunity |
| title_full_unstemmed |
Activity of Alzheimer’s γ-secretase is linked to changes of interferon-induced transmembrane proteins (IFITM) in innate immunity |
| title_sort |
activity of alzheimer’s γ-secretase is linked to changes of interferon-induced transmembrane proteins (ifitm) in innate immunity |
| publisher |
BMC |
| series |
Molecular Neurodegeneration |
| issn |
1750-1326 |
| publishDate |
2020-11-01 |
| description |
Abstract The activity of γ-secretase is critical to the pathogenesis of Alzheimer’s disease (AD). How its activity is regulated is intriguing and highly important for any AD therapy that focuses on reduction of toxic amyloid peptides and amyloid deposition in patients. Recently, interferon-induced transmembrane protein 3 (IFITM3) has been identified as a novel regulator of γ-secretase through a specific interaction. This commentary highlights this exciting study and provides an updated link of γ-secretase activity to innate immunity through IFITM3. |
| topic |
Γ-secretase Presenilin Nicastrin Interferon-induced transmembrane protein IFITM3 Innate immunity |
| url |
http://link.springer.com/article/10.1186/s13024-020-00417-0 |
| work_keys_str_mv |
AT annieyyao activityofalzheimersgsecretaseislinkedtochangesofinterferoninducedtransmembraneproteinsifitmininnateimmunity AT riqiangyan activityofalzheimersgsecretaseislinkedtochangesofinterferoninducedtransmembraneproteinsifitmininnateimmunity |
| _version_ |
1724427653181603840 |