TNFR2: The new Treg switch?

TNFR2: The new Treg switch?

Three recent publications identified the TNF/TNR2 pathway as a new target to reduce graft-versus-host-disease through regulatory T cells activation or to potentially switch on a strong anti-leukemic effect through regulatory T cells blockade in allogeneic hematopoietic stem cell transplantation. Thi...

Full description

Bibliographic Details
Main Authors:	José L. Cohen, Kathryn J. Wood
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2018-01-01
Series:	OncoImmunology
Subjects:	immune checkpoint immunotherapy tnfr2 treg immunomodulation
Online Access:	http://dx.doi.org/10.1080/2162402X.2017.1373236

Similar Items

TNFR1 and TNFR2 Expression and Induction on Human Treg Cells from Type 1 Diabetic Subjects
by: Melanie Heinrich, et al.
Published: (2015-03-01)

Chronic Inflammation Increases the Sensitivity of Mouse Treg for TNFR2 Costimulation
by: Tobias Schmid, et al.
Published: (2017-11-01)

Papel dos receptores de TNF no desenvolvimento da imunossupressão pós-sepse
by: Paulo Henrique de Melo
Published: (2013)

Papel dos receptores de TNF no desenvolvimento da imunossupressão pós-sepse
by: Melo, Paulo Henrique de
Published: (2013)

TNFR1 and TNFR2 in the Control of the Life and Death Balance of Macrophages
by: Harald Wajant, et al.
Published: (2019-05-01)

Preclinical and clinical aspects of TNF-α and its receptors TNFR1 and TNFR2 in breast cancer
by: Isela Martínez-Reza, et al.
Published: (2017-12-01)

The immune molecular landscape of the B7 and TNFR immunoregulatory ligand–receptor families in head and neck cancer: A comprehensive overview and the immunotherapeutic implications
by: Yu-Pei Chen, et al.
Published: (2017-03-01)

TNFR2: Role in Cancer Immunology and Immunotherapy
by: Yang Y, et al.
Published: (2021-04-01)

Regulatory T cell induction by mesenchymal stem cells depends on the expression of TNFR2 by T cells
by: Sina Naserian, et al.
Published: (2020-12-01)

The comprehensive molecular landscape of the immunologic co-stimulator B7 and TNFR ligand receptor families in colorectal cancer: immunotherapeutic implications with microsatellite instability
by: Jinghua Tang, et al.
Published: (2018-10-01)

Superior Treg-Expanding Properties of a Novel Dual-Acting Cytokine Fusion Protein
by: Tanja Padutsch, et al.
Published: (2019-12-01)

TNFα and Immune Checkpoint Inhibition: Friend or Foe for Lung Cancer?
by: Thomas Benoot, et al.
Published: (2021-08-01)

TNFR2 Is a Crucial Hub Controlling Mesenchymal Stem Cell Biological and Functional Properties
by: Ghada Beldi, et al.
Published: (2020-12-01)

TNFα/TNFR2 signaling pathway: an active immune checkpoint for mesenchymal stem cell immunoregulatory function
by: Ghada Beldi, et al.
Published: (2020-07-01)

Corrigendum: TNFR2 Is a Crucial Hub Controlling Mesenchymal Stem Cell Biological and Functional Properties
by: Ghada Beldi, et al.
Published: (2021-08-01)

The TNF/TNFR2 signaling pathway is a key regulatory factor in endothelial progenitor cell immunosuppressive effect
by: Sina Naserian, et al.
Published: (2020-06-01)

TNFα-TNFR2 signaling pathway in control of the neural stem/progenitor cell immunosuppressive effect: Different experimental approaches to assess this hypothetical mechanism behind their immunological function
by: Sara Shamdani, et al.
Published: (2020-07-01)

The Impact of Tregs on the Anticancer Immunity and the Efficacy of Immune Checkpoint Inhibitor Therapies
by: Jose M. González-Navajas, et al.
Published: (2021-02-01)

Role of CD4+CD25+FOXP3+ TReg cells on tumor immunity
by: Agustinus Darmadi Hariyanto, et al.
Published: (2021-09-01)

Do natural Treg become activated to antigen specific Treg in transplantation and in autoimmunity?
by: Bruce Milne Hall, et al.
Published: (2013-08-01)

Selective Blockade of TNFR1 Improves Clinical Disease and Bronchoconstriction in Experimental RSV Infection
by: Dorothea R. Morris, et al.
Published: (2020-10-01)

Atsttrin Promotes Cartilage Repair Primarily Through TNFR2-Akt Pathway
by: Jianlu Wei, et al.
Published: (2020-10-01)

Immune Checkpoint Expression on Immune Cells of HNSCC Patients and Modulation by Chemo- and Immunotherapy
by: Lisa K. Puntigam, et al.
Published: (2020-07-01)

Blockade of TIM3 relieves immunosuppression through reducing regulatory T cells in head and neck cancer
by: Jian-Feng Liu, et al.
Published: (2018-03-01)

Severe COVID-19 Patients Show an Increase in Soluble TNFR1 and ADAM17, with a Relationship to Mortality
by: Yadira Palacios, et al.
Published: (2021-08-01)

Brazilian green propolis promotes TNFR2 expression on regulatory T cells
by: Norihisa Mikami, et al.
Published: (2021-06-01)

ICOS+ Tregs: A Functional Subset of Tregs in Immune Diseases
by: Dan-Yang Li, et al.
Published: (2020-08-01)

Corrigendum: ICOS+ Tregs: A Functional Subset of Tregs in Immune Diseases
by: Dan-Yang Li, et al.
Published: (2021-05-01)

The Key Role of TNF-TNFR2 Interactions in the Modulation of Allergic Inflammation: A Review
by: Suhana Ahmad, et al.
Published: (2018-11-01)

Targeting Regulatory T Cells by Addressing Tumor Necrosis Factor and Its Receptors in Allogeneic Hematopoietic Cell Transplantation and Cancer
by: Harald Wajant, et al.
Published: (2019-08-01)

Radiotherapy-Mediated Immunomodulation and Anti-Tumor Abscopal Effect Combining Immune Checkpoint Blockade
by: Xinrui Zhao, et al.
Published: (2020-09-01)

TNF-α enhances Th9 cell differentiation and antitumor immunity via TNFR2-dependent pathways
by: Yuxue Jiang, et al.
Published: (2019-02-01)

TNFα priming through its interaction with TNFR2 enhances endothelial progenitor cell immunosuppressive effect: new hope for their widespread clinical application
by: Mahsa Nouri Barkestani, et al.
Published: (2021-01-01)

Induction of antigen-specific Treg cells in treating autoimmune uveitis via bystander suppressive pathways without compromising anti-tumor immunity
by: Zilin Chen, et al.
Published: (2021-08-01)

“High Treg” Inflammations Promote (Most) Non-Hematologic Cancers While “Low Treg” Inflammations Promote Lymphoid Cancers
by: Elkoshi Z
Published: (2020-05-01)

Arsenic trioxide induce apoptosis independent of TNFR-I and CD30 pathways in Acute promyelocytic leukemia patient with t(15;17) translocation.
by: Ardjmand.AR, et al.
Published: (2005-06-01)

Editorial: TNFR Superfamily Oligomerization and Signaling
by: Olivier Micheau, et al.
Published: (2021-04-01)

Lymphoma: Immune Evasion Strategies
by: Ranjan Upadhyay, et al.
Published: (2015-04-01)

Treg: A Promising Immunotherapeutic Target in Oral Diseases
by: Yujing Zhang, et al.
Published: (2021-06-01)

Temporal Ordering of Inflammatory Analytes sTNFR2 and sTREM2 in Relation to Alzheimer's Disease Biomarkers and Clinical Outcomes
by: Jagan A. Pillai, et al.
Published: (2021-06-01)