Using a Human Papillomavirus Model to Study DNA Replication and Repair of Wild Type and Damaged DNA Templates in Mammalian Cells

Using a Human Papillomavirus Model to Study DNA Replication and Repair of Wild Type and Damaged DNA Templates in Mammalian Cells

Human papillomaviruses have 8kbp DNA episomal genomes that replicate autonomously from host DNA. During initial infection, the virus increases its copy number to 20–50 copies per cell, causing torsional stress on the replicating DNA. This activates the DNA damage response (DDR) and HPV replicates it...

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Bibliographic Details
Main Authors: Dipon Das, Molly L. Bristol, Pietro Pichierri, Iain M. Morgan
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
human papillomaviruses
DNA replication
replication and repair
DNA damage
model system
E1 and E2
Online Access:https://www.mdpi.com/1422-0067/21/20/7564

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