Fibroblasts: Heterogeneous Cells With Potential in Regenerative Therapy for Scarless Wound Healing
In recent years, research on wound healing has become increasingly in-depth, but therapeutic effects are still not satisfactory. Occasionally, pathological tissue repair occurs. Influencing factors have been proposed, but finding the turning point between normal and pathological tissue repair is dif...
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doaj-df0516dc95294f3f8f79a679d24488cd2021-07-20T12:30:14ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-07-01910.3389/fcell.2021.713605713605Fibroblasts: Heterogeneous Cells With Potential in Regenerative Therapy for Scarless Wound HealingMing-Li Zou0Ying-Ying Teng1Jun-Jie Wu2Si-Yu Liu3Xiao-Yu Tang4Yuan Jia5Zhong-Hua Chen6Kai-Wen Zhang7Zi-Li Sun8Xia Li9Jun-Xing Ye10Rui-Sheng Xu11Feng-Lai Yuan12Feng-Lai Yuan13Wuxi Clinical Medicine School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Wuxi, ChinaInstitute of Integrated Traditional Chinese and Western Medicine, The Affiliated Hospital of Jiangnan University, Wuxi, ChinaInstitute of Integrated Traditional Chinese and Western Medicine, The Affiliated Hospital of Jiangnan University, Wuxi, ChinaWuxi Clinical Medicine School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Wuxi, ChinaWuxi Clinical Medicine School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Wuxi, ChinaWuxi Clinical Medicine School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Wuxi, ChinaInstitute of Integrated Traditional Chinese and Western Medicine, The Third Hospital Affiliated to Nantong University, Wuxi, ChinaWuxi Clinical Medicine School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Wuxi, ChinaWuxi Clinical Medicine School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Wuxi, ChinaInstitute of Integrated Traditional Chinese and Western Medicine, The Affiliated Hospital of Jiangnan University, Wuxi, ChinaInstitute of Integrated Traditional Chinese and Western Medicine, The Affiliated Hospital of Jiangnan University, Wuxi, ChinaInstitute of Integrated Traditional Chinese and Western Medicine, The Affiliated Hospital of Jiangnan University, Wuxi, ChinaWuxi Clinical Medicine School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Wuxi, ChinaInstitute of Integrated Traditional Chinese and Western Medicine, The Affiliated Hospital of Jiangnan University, Wuxi, ChinaIn recent years, research on wound healing has become increasingly in-depth, but therapeutic effects are still not satisfactory. Occasionally, pathological tissue repair occurs. Influencing factors have been proposed, but finding the turning point between normal and pathological tissue repair is difficult. Therefore, we focused our attention on the most basic level of tissue repair: fibroblasts. Fibroblasts were once considered terminally differentiated cells that represent a single cell type, and their heterogeneity was not studied until recently. We believe that subpopulations of fibroblasts play different roles in tissue repair, resulting in different repair results, such as the formation of normal scars in physiological tissue repair and fibrosis or ulcers in pathological tissue repair. It is also proposed that scarless healing can be achieved by regulating fibroblast subpopulations.https://www.frontiersin.org/articles/10.3389/fcell.2021.713605/fullpapillary fibroblastsscarless wound healingtissue repairreticular fibroblastdermal-subcutaneous junction fibroblasts |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ming-Li Zou Ying-Ying Teng Jun-Jie Wu Si-Yu Liu Xiao-Yu Tang Yuan Jia Zhong-Hua Chen Kai-Wen Zhang Zi-Li Sun Xia Li Jun-Xing Ye Rui-Sheng Xu Feng-Lai Yuan Feng-Lai Yuan |
spellingShingle |
Ming-Li Zou Ying-Ying Teng Jun-Jie Wu Si-Yu Liu Xiao-Yu Tang Yuan Jia Zhong-Hua Chen Kai-Wen Zhang Zi-Li Sun Xia Li Jun-Xing Ye Rui-Sheng Xu Feng-Lai Yuan Feng-Lai Yuan Fibroblasts: Heterogeneous Cells With Potential in Regenerative Therapy for Scarless Wound Healing Frontiers in Cell and Developmental Biology papillary fibroblasts scarless wound healing tissue repair reticular fibroblast dermal-subcutaneous junction fibroblasts |
author_facet |
Ming-Li Zou Ying-Ying Teng Jun-Jie Wu Si-Yu Liu Xiao-Yu Tang Yuan Jia Zhong-Hua Chen Kai-Wen Zhang Zi-Li Sun Xia Li Jun-Xing Ye Rui-Sheng Xu Feng-Lai Yuan Feng-Lai Yuan |
author_sort |
Ming-Li Zou |
title |
Fibroblasts: Heterogeneous Cells With Potential in Regenerative Therapy for Scarless Wound Healing |
title_short |
Fibroblasts: Heterogeneous Cells With Potential in Regenerative Therapy for Scarless Wound Healing |
title_full |
Fibroblasts: Heterogeneous Cells With Potential in Regenerative Therapy for Scarless Wound Healing |
title_fullStr |
Fibroblasts: Heterogeneous Cells With Potential in Regenerative Therapy for Scarless Wound Healing |
title_full_unstemmed |
Fibroblasts: Heterogeneous Cells With Potential in Regenerative Therapy for Scarless Wound Healing |
title_sort |
fibroblasts: heterogeneous cells with potential in regenerative therapy for scarless wound healing |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cell and Developmental Biology |
issn |
2296-634X |
publishDate |
2021-07-01 |
description |
In recent years, research on wound healing has become increasingly in-depth, but therapeutic effects are still not satisfactory. Occasionally, pathological tissue repair occurs. Influencing factors have been proposed, but finding the turning point between normal and pathological tissue repair is difficult. Therefore, we focused our attention on the most basic level of tissue repair: fibroblasts. Fibroblasts were once considered terminally differentiated cells that represent a single cell type, and their heterogeneity was not studied until recently. We believe that subpopulations of fibroblasts play different roles in tissue repair, resulting in different repair results, such as the formation of normal scars in physiological tissue repair and fibrosis or ulcers in pathological tissue repair. It is also proposed that scarless healing can be achieved by regulating fibroblast subpopulations. |
topic |
papillary fibroblasts scarless wound healing tissue repair reticular fibroblast dermal-subcutaneous junction fibroblasts |
url |
https://www.frontiersin.org/articles/10.3389/fcell.2021.713605/full |
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