The incidence rate, trend and microbiological aetiology of prosthetic joint infection after total knee arthroplasty: A 13 years’ experience from a tertiary medical center in Taiwan
Background/purpose: Total knee arthroplasty (TKA) improves the patient's quality of life by relieving pain, correcting the deformity, and helping the patient resume normal activities. However, post-TKA prosthetic joint infection leads to implant failure, is difficult to treat, and causes a sign...
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doaj-df0fd05956544efbb04216fa227690e12020-11-25T02:32:04ZengElsevierJournal of Microbiology, Immunology and Infection1684-11822018-12-01516717722The incidence rate, trend and microbiological aetiology of prosthetic joint infection after total knee arthroplasty: A 13 years’ experience from a tertiary medical center in TaiwanFu-Der Wang0Yu-Ping Wang1Cheng-Fong Chen2Hsin-Pai Chen3Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan; Correspondence author. Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, 201 Shih-Pai Road, Sec. 2, Taipei 11247, Taiwan. Fax: +886 2 2873 5656.Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, Taipei, TaiwanDepartment of Orthopedics and Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Orthopedics, School of Medicine, National Yang-Ming University, Taipei, TaiwanDivision of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang-Ming University, Taipei, TaiwanBackground/purpose: Total knee arthroplasty (TKA) improves the patient's quality of life by relieving pain, correcting the deformity, and helping the patient resume normal activities. However, post-TKA prosthetic joint infection leads to implant failure, is difficult to treat, and causes a significant burden both economically and health-wise. Therefore, an understanding of the current trends in this infection and microbiology data is essential for preventing and treating it. Methods: A retrospective study was conducted on 10,768 patients who underwent primary TKA at Taipei Veterans General Hospital, Taiwan, from 2002 to 2014. The incidence of post-TKA prosthetic joint infection in different time periods was investigated, and microbiological results in early- (<3 months post-TKA) and delay-onset prosthetic joint infection were analyzed. Results: The 2 years incidence of post-TKA prosthetic joint infection was 1.93% (2002–2006), 1.05% (2007–2010), and 0.76% (2011–2014). The incidence of post-TKA prosthetic joint infection decreased significantly from 2002 to 2014. Although Staphylococcus species was most commonly isolated, a significantly higher proportion of gram-negative bacteria were isolated from early-onset compared with delay-onset post-TKA prosthetic joint infection patients: 9/29 (31.0%) versus 13/100 (13%); p = 0.023. Conclusions: The results showed that the risk of post-TKA prosthetic joint infection is decreasing. Microbiology results showed that early-onset post-TKA prosthetic joint infection is associated with a higher risk of gram-negative bacterial infection. Physicians should be aware of this risk in order to correctly select empirical agents. Keywords: Prosthetic joint infection, Total knee arthroplasty, Microbiological aetiologyhttp://www.sciencedirect.com/science/article/pii/S1684118218302731 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fu-Der Wang Yu-Ping Wang Cheng-Fong Chen Hsin-Pai Chen |
spellingShingle |
Fu-Der Wang Yu-Ping Wang Cheng-Fong Chen Hsin-Pai Chen The incidence rate, trend and microbiological aetiology of prosthetic joint infection after total knee arthroplasty: A 13 years’ experience from a tertiary medical center in Taiwan Journal of Microbiology, Immunology and Infection |
author_facet |
Fu-Der Wang Yu-Ping Wang Cheng-Fong Chen Hsin-Pai Chen |
author_sort |
Fu-Der Wang |
title |
The incidence rate, trend and microbiological aetiology of prosthetic joint infection after total knee arthroplasty: A 13 years’ experience from a tertiary medical center in Taiwan |
title_short |
The incidence rate, trend and microbiological aetiology of prosthetic joint infection after total knee arthroplasty: A 13 years’ experience from a tertiary medical center in Taiwan |
title_full |
The incidence rate, trend and microbiological aetiology of prosthetic joint infection after total knee arthroplasty: A 13 years’ experience from a tertiary medical center in Taiwan |
title_fullStr |
The incidence rate, trend and microbiological aetiology of prosthetic joint infection after total knee arthroplasty: A 13 years’ experience from a tertiary medical center in Taiwan |
title_full_unstemmed |
The incidence rate, trend and microbiological aetiology of prosthetic joint infection after total knee arthroplasty: A 13 years’ experience from a tertiary medical center in Taiwan |
title_sort |
incidence rate, trend and microbiological aetiology of prosthetic joint infection after total knee arthroplasty: a 13 years’ experience from a tertiary medical center in taiwan |
publisher |
Elsevier |
series |
Journal of Microbiology, Immunology and Infection |
issn |
1684-1182 |
publishDate |
2018-12-01 |
description |
Background/purpose: Total knee arthroplasty (TKA) improves the patient's quality of life by relieving pain, correcting the deformity, and helping the patient resume normal activities. However, post-TKA prosthetic joint infection leads to implant failure, is difficult to treat, and causes a significant burden both economically and health-wise. Therefore, an understanding of the current trends in this infection and microbiology data is essential for preventing and treating it. Methods: A retrospective study was conducted on 10,768 patients who underwent primary TKA at Taipei Veterans General Hospital, Taiwan, from 2002 to 2014. The incidence of post-TKA prosthetic joint infection in different time periods was investigated, and microbiological results in early- (<3 months post-TKA) and delay-onset prosthetic joint infection were analyzed. Results: The 2 years incidence of post-TKA prosthetic joint infection was 1.93% (2002–2006), 1.05% (2007–2010), and 0.76% (2011–2014). The incidence of post-TKA prosthetic joint infection decreased significantly from 2002 to 2014. Although Staphylococcus species was most commonly isolated, a significantly higher proportion of gram-negative bacteria were isolated from early-onset compared with delay-onset post-TKA prosthetic joint infection patients: 9/29 (31.0%) versus 13/100 (13%); p = 0.023. Conclusions: The results showed that the risk of post-TKA prosthetic joint infection is decreasing. Microbiology results showed that early-onset post-TKA prosthetic joint infection is associated with a higher risk of gram-negative bacterial infection. Physicians should be aware of this risk in order to correctly select empirical agents. Keywords: Prosthetic joint infection, Total knee arthroplasty, Microbiological aetiology |
url |
http://www.sciencedirect.com/science/article/pii/S1684118218302731 |
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