Dissolution profile evaluation of solid pharmaceutical forms containing chloramphenicol marketed in Brazil
The dissolution profile for solid pharmaceutical forms containing chloramphenicol 250 mg available in Brazil was determined using a method from the American Pharmacopoeia (United States Pharmacopoeia, 2004) and then compared. Two different methods of dissolution profile comparison were used: ANOVA,...
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Instituto de Tecnologia do Paraná (Tecpar)
2007-01-01
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doaj-df1479ba07d74b5ea47e00d67f7b77cc2020-11-25T00:10:57ZengInstituto de Tecnologia do Paraná (Tecpar)Brazilian Archives of Biology and Technology1516-89131678-43242007-01-01501576510.1590/S1516-89132007000100007Dissolution profile evaluation of solid pharmaceutical forms containing chloramphenicol marketed in BrazilHumberto Gomes FerrazLeticia Norma CarpentieriSayuri Pereira WatanabeThe dissolution profile for solid pharmaceutical forms containing chloramphenicol 250 mg available in Brazil was determined using a method from the American Pharmacopoeia (United States Pharmacopoeia, 2004) and then compared. Two different methods of dissolution profile comparison were used: ANOVA, and an independent model. Differences between the formulations were reflected in the dissolution profiles. The presence of metastable polymorphs or amorphous forms of chloramphenicol palmitate might be responsible for variations in the concentration of the drug observed within formulations.<br>O perfil de dissolução de formas farmacêuticas sólidas contendo palmitato de cloranfenicol 250 mg disponíveis no Brasil foi determinada pelo método da Farmacopéia Americana (United States Pharmacopeia, 2004) e comparado. Duas categorias de métodos para comparação dos perfis de dissolução foram utilizadas: ANOVA e modelo independente. Diferenças entre as formulações foram refletidas nos perfis de dissolução. A presença de polimorfos metaestáveis ou formas amorfas de palmitato de cloranfenicol pode ser responsável pelas variações na concentração do fármaco observada nas formulações.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000100007ChloramphenicolDissolutionPolymorphism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Humberto Gomes Ferraz Leticia Norma Carpentieri Sayuri Pereira Watanabe |
spellingShingle |
Humberto Gomes Ferraz Leticia Norma Carpentieri Sayuri Pereira Watanabe Dissolution profile evaluation of solid pharmaceutical forms containing chloramphenicol marketed in Brazil Brazilian Archives of Biology and Technology Chloramphenicol Dissolution Polymorphism |
author_facet |
Humberto Gomes Ferraz Leticia Norma Carpentieri Sayuri Pereira Watanabe |
author_sort |
Humberto Gomes Ferraz |
title |
Dissolution profile evaluation of solid pharmaceutical forms containing chloramphenicol marketed in Brazil |
title_short |
Dissolution profile evaluation of solid pharmaceutical forms containing chloramphenicol marketed in Brazil |
title_full |
Dissolution profile evaluation of solid pharmaceutical forms containing chloramphenicol marketed in Brazil |
title_fullStr |
Dissolution profile evaluation of solid pharmaceutical forms containing chloramphenicol marketed in Brazil |
title_full_unstemmed |
Dissolution profile evaluation of solid pharmaceutical forms containing chloramphenicol marketed in Brazil |
title_sort |
dissolution profile evaluation of solid pharmaceutical forms containing chloramphenicol marketed in brazil |
publisher |
Instituto de Tecnologia do Paraná (Tecpar) |
series |
Brazilian Archives of Biology and Technology |
issn |
1516-8913 1678-4324 |
publishDate |
2007-01-01 |
description |
The dissolution profile for solid pharmaceutical forms containing chloramphenicol 250 mg available in Brazil was determined using a method from the American Pharmacopoeia (United States Pharmacopoeia, 2004) and then compared. Two different methods of dissolution profile comparison were used: ANOVA, and an independent model. Differences between the formulations were reflected in the dissolution profiles. The presence of metastable polymorphs or amorphous forms of chloramphenicol palmitate might be responsible for variations in the concentration of the drug observed within formulations.<br>O perfil de dissolução de formas farmacêuticas sólidas contendo palmitato de cloranfenicol 250 mg disponíveis no Brasil foi determinada pelo método da Farmacopéia Americana (United States Pharmacopeia, 2004) e comparado. Duas categorias de métodos para comparação dos perfis de dissolução foram utilizadas: ANOVA e modelo independente. Diferenças entre as formulações foram refletidas nos perfis de dissolução. A presença de polimorfos metaestáveis ou formas amorfas de palmitato de cloranfenicol pode ser responsável pelas variações na concentração do fármaco observada nas formulações. |
topic |
Chloramphenicol Dissolution Polymorphism |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000100007 |
work_keys_str_mv |
AT humbertogomesferraz dissolutionprofileevaluationofsolidpharmaceuticalformscontainingchloramphenicolmarketedinbrazil AT leticianormacarpentieri dissolutionprofileevaluationofsolidpharmaceuticalformscontainingchloramphenicolmarketedinbrazil AT sayuripereirawatanabe dissolutionprofileevaluationofsolidpharmaceuticalformscontainingchloramphenicolmarketedinbrazil |
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