Immunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy

Current strategies to boost anti-tumor immune response include the use of immune checkpoint inhibitors and bispecific T cell-engaging antibodies. Here the authors describe a versatile antibody immobilization nanoplatform that can be used to deliver different combinations of immunotherapeutics, showi...

Full description

Bibliographic Details
Main Authors:	Cheng-Tao Jiang, Kai-Ge Chen, An Liu, Hua Huang, Ya-Nan Fan, Dong-Kun Zhao, Qian-Ni Ye, Hou-Bing Zhang, Cong-Fei Xu, Song Shen, Meng-Hua Xiong, Jin-Zhi Du, Xian-Zhu Yang, Jun Wang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-03-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-21497-6

id	doaj-df1fd3f94ada4483a1c1ec207bb754dd
record_format	Article
spelling	doaj-df1fd3f94ada4483a1c1ec207bb754dd2021-03-11T11:32:22ZengNature Publishing GroupNature Communications2041-17232021-03-0112111410.1038/s41467-021-21497-6Immunomodulating nano-adaptors potentiate antibody-based cancer immunotherapyCheng-Tao Jiang0Kai-Ge Chen1An Liu2Hua Huang3Ya-Nan Fan4Dong-Kun Zhao5Qian-Ni Ye6Hou-Bing Zhang7Cong-Fei Xu8Song Shen9Meng-Hua Xiong10Jin-Zhi Du11Xian-Zhu Yang12Jun Wang13School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International CampusSchool of Life Sciences, University of Science and Technology of ChinaSchool of Life Sciences, University of Science and Technology of ChinaSchool of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International CampusSchool of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International CampusSchool of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International CampusSchool of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International CampusSchool of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International CampusSchool of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International CampusSchool of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International CampusSchool of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International CampusSchool of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International CampusSchool of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International CampusSchool of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International CampusCurrent strategies to boost anti-tumor immune response include the use of immune checkpoint inhibitors and bispecific T cell-engaging antibodies. Here the authors describe a versatile antibody immobilization nanoplatform that can be used to deliver different combinations of immunotherapeutics, showing therapeutic superiority in pre-clinical models.https://doi.org/10.1038/s41467-021-21497-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Cheng-Tao Jiang Kai-Ge Chen An Liu Hua Huang Ya-Nan Fan Dong-Kun Zhao Qian-Ni Ye Hou-Bing Zhang Cong-Fei Xu Song Shen Meng-Hua Xiong Jin-Zhi Du Xian-Zhu Yang Jun Wang
spellingShingle	Cheng-Tao Jiang Kai-Ge Chen An Liu Hua Huang Ya-Nan Fan Dong-Kun Zhao Qian-Ni Ye Hou-Bing Zhang Cong-Fei Xu Song Shen Meng-Hua Xiong Jin-Zhi Du Xian-Zhu Yang Jun Wang Immunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy Nature Communications
author_facet	Cheng-Tao Jiang Kai-Ge Chen An Liu Hua Huang Ya-Nan Fan Dong-Kun Zhao Qian-Ni Ye Hou-Bing Zhang Cong-Fei Xu Song Shen Meng-Hua Xiong Jin-Zhi Du Xian-Zhu Yang Jun Wang
author_sort	Cheng-Tao Jiang
title	Immunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy
title_short	Immunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy
title_full	Immunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy
title_fullStr	Immunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy
title_full_unstemmed	Immunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy
title_sort	immunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-03-01
description	Current strategies to boost anti-tumor immune response include the use of immune checkpoint inhibitors and bispecific T cell-engaging antibodies. Here the authors describe a versatile antibody immobilization nanoplatform that can be used to deliver different combinations of immunotherapeutics, showing therapeutic superiority in pre-clinical models.
url	https://doi.org/10.1038/s41467-021-21497-6
work_keys_str_mv	AT chengtaojiang immunomodulatingnanoadaptorspotentiateantibodybasedcancerimmunotherapy AT kaigechen immunomodulatingnanoadaptorspotentiateantibodybasedcancerimmunotherapy AT anliu immunomodulatingnanoadaptorspotentiateantibodybasedcancerimmunotherapy AT huahuang immunomodulatingnanoadaptorspotentiateantibodybasedcancerimmunotherapy AT yananfan immunomodulatingnanoadaptorspotentiateantibodybasedcancerimmunotherapy AT dongkunzhao immunomodulatingnanoadaptorspotentiateantibodybasedcancerimmunotherapy AT qianniye immunomodulatingnanoadaptorspotentiateantibodybasedcancerimmunotherapy AT houbingzhang immunomodulatingnanoadaptorspotentiateantibodybasedcancerimmunotherapy AT congfeixu immunomodulatingnanoadaptorspotentiateantibodybasedcancerimmunotherapy AT songshen immunomodulatingnanoadaptorspotentiateantibodybasedcancerimmunotherapy AT menghuaxiong immunomodulatingnanoadaptorspotentiateantibodybasedcancerimmunotherapy AT jinzhidu immunomodulatingnanoadaptorspotentiateantibodybasedcancerimmunotherapy AT xianzhuyang immunomodulatingnanoadaptorspotentiateantibodybasedcancerimmunotherapy AT junwang immunomodulatingnanoadaptorspotentiateantibodybasedcancerimmunotherapy
_version_	1724225438896619520

Immunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy

Similar Items